Abstract
Dementia is a collection of symptoms affecting a person’s cognition. Dementia is debilitating, and therefore, finding an effective treatment is of utmost importance. Resveratrol, which exhibits neuroprotective effects, has low bioavailability. However, its glucoside polydatin is more bioavailable. Here, the evidence that supports the protective role of polydatin against dementia- related diseases such as Alzheimer’s disease, vascular dementia, alcohol-related dementia, and Lewy body dementias is presented. The beneficial effects of polydatin from a mechanistic perspective are specifically emphasized in this review. Future directions in this area of research are also discussed.
Graphical Abstract
Current Neuropharmacology
Title:Protective Effects of Polydatin Against Dementia-Related Disorders
Volume: 19 Issue: 2
Author(s): Kim San Tang*
Affiliation:
- School of Pharmacy, Monash University Malaysia, Bandar Sunway, Selangor,Malaysia
Abstract: Dementia is a collection of symptoms affecting a person’s cognition. Dementia is debilitating, and therefore, finding an effective treatment is of utmost importance. Resveratrol, which exhibits neuroprotective effects, has low bioavailability. However, its glucoside polydatin is more bioavailable. Here, the evidence that supports the protective role of polydatin against dementia- related diseases such as Alzheimer’s disease, vascular dementia, alcohol-related dementia, and Lewy body dementias is presented. The beneficial effects of polydatin from a mechanistic perspective are specifically emphasized in this review. Future directions in this area of research are also discussed.
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Cite this article as:
Tang Kim San*, Protective Effects of Polydatin Against Dementia-Related Disorders, Current Neuropharmacology 2021; 19 (2) . https://dx.doi.org/10.2174/1570159X18666200611144825
DOI https://dx.doi.org/10.2174/1570159X18666200611144825 |
Print ISSN 1570-159X |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6190 |
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