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Review Article

间充质干细胞：新一代治疗药物作为基因治疗的载体。

卷 20, 期 4, 2020

页: [269 - 284] 页: 16

弟呕挨: 10.2174/1566523220666200607190339

价格: $65

摘要

近年来，间充质干细胞（MSCs）作为临床上用于治疗性基因递送的新工具引起了广泛关注。它们的优势包括更长的寿命，更好的分离以及更高的转染效率和增殖率。 MSC是基于细胞的疗法的首选方法，因为它们具有体外自我更新能力，尤其是迁移到肿瘤组织，以及抗炎和免疫调节特性。因此，它们在基因工程方面具有相当大的效率，可用于癌症基因治疗和其他疾病的未来临床应用。为了提高治疗效率，可以通过持续释放治疗剂并将功能基因表达诱导至目标组织来实现癌症的靶向治疗。基因治疗中新载体的开发可以提高转基因表达的持久性。同样，载体的安全性，如果全身给药，可以解决几个问题，例如表达的持久性和宿主免疫应答。当前，由于治疗剂在几种癌症中的分泌，MSC在临床前和临床试验中都是细胞载体的重要候选者。在本研究中，我们讨论了病毒和非病毒载体中基因治疗的现状及其局限性。在整个研究过程中，还研究了几种纳米载体在基因治疗中的应用。最后，我们批判性地讨论了MSC在靶向基因递送，肿瘤抑制及其在临床中作为基因载体的利用方面的有前途的优势。

关键词: 基因疗法，间充质干细胞，纳米载体载体，基因免疫疗法，骨髓，细胞疗法载体。

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