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Review Article

Nanoemulsion: A Novel Drug Delivery Approach for Enhancement of Bioavailability

Author(s): Parijat Pandey, Nisha Gulati, Manish Makhija, Deepika Purohit and Harish Dureja*

Volume 14, Issue 4, 2020

Page: [276 - 293] Pages: 18

DOI: 10.2174/1872210514666200604145755

Price: $65

Abstract

Background: Poor bioavailability and solubility of drugs in aqueous phase are the most important problems of newly developed chemical entities that can be improved by nanoemulsion.

Objectives: BCS class II and IV which are poorly soluble in water demonstrate various problems in conventional dosage forms. For the improvement of solubility, bioavailability and getting the best therapeutic effect of poorly soluble drugs nanoemulsion is the best solution.

Methods: Nanoemulsion are thermodynamically unstable isotropic system with droplet size 1-100 nm in which two immiscible fluids are combined together to form one phase by using an emulsifying agent. Nanoemulsion can be designed to promote the bioavailability of API by trapping them inside.

Results: Nanoemulsion can be developed in many dosage forms such as oral, parenteral, topical, ophthalmic dosage form in large scale using common operation at a very low cost. Large range of lipophilic drugs can be easily incorporated in nanoemulsion.

Conclusion: In this review, attention is focused on the type of nanoemulsions, their advantages over other dosage form, method for their preparation, characterization, applications and patents in various fields.

Keywords: Nanoemulsion, bioavailability, solubility enhancement, nanoemulsion, emulsification methods, isotropic system.

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[1]
Wen H, Jung H, Li X. Drug delivery approaches in addressing clinical pharmacology related issues: Opportunities and challenges. AAPS J 2015; 17(6): 1327-40.
[http://dx.doi.org/10.1208/s12248-015-9814-9] [PMID: 26276218]
[2]
Kalepu S, Nekkanti V. Insoluble drug delivery strategies: Review of recent advances and business prospects. Acta Pharm Sin B 2015; 5(5): 442-53.
[http://dx.doi.org/10.1016/j.apsb.2015.07.003] [PMID: 26579474]
[3]
Patel RP, Joshi JR. An overview on nanoemulsion: A novel approach. Int J Pharm Sci Res 2012; 3(12): 4640-8.
[4]
Gutierrez JM, Gonzalez C, Maestro A, Sole IMPC, Pey CM, Nolla J. Nano-emulsions: New applications and optimization of their preparation. Curr Opin Colloid Interface Sci 2008; 13(4): 245-51.
[http://dx.doi.org/10.1016/j.cocis.2008.01.005]
[5]
Khatri S, Lohani P, Gandhi S. Nanoemulsions in cancer therapy. Indo Global J Pharm Sci 2013; 3(2): 124-33.
[6]
Solans C, Izquierdo P, Nolla J, Azemar N, Garcia-Celma MJ. Nano-emulsions. Curr Opin Colloid Interface Sci 2005; 10(3-4): 102-10.
[http://dx.doi.org/10.1016/j.cocis.2005.06.004]
[7]
Singh Y, Meher JG, Raval K, et al. Nanoemulsion: Concepts, development and applications in drug delivery. J Control Release 2017; 252: 28-49.
[http://dx.doi.org/10.1016/j.jconrel.2017.03.008] [PMID: 28279798]
[8]
McClements DJ. Nanoemulsions vs microemulsions: Terminology, differences, and similarities. Soft Matter 2012; 8(6): 1719-29.
[http://dx.doi.org/10.1039/C2SM06903B]
[9]
Gué E, Since M, Ropars S, Herbinet R, Le Pluart L, Malzert-Fréon A. Evaluation of the versatile character of a nanoemulsion formulation. Int J Pharm 2016; 498(1-2): 49-65.
[http://dx.doi.org/10.1016/j.ijpharm.2015.12.010] [PMID: 26685727]
[10]
Chaudhari PM, Kuchekar MA. Development and evaluation of nanoemulsion as a carrier for topical delivery system by box-behnken design. Asian J Pharm Clin Res 2018; 11(8): 286-93.
[http://dx.doi.org/10.22159/ajpcr.2018.v11i8.26359]
[11]
Ahmed M, Ramadan W, Rambhu D, Shakeel F. Potential of nanoemulsions for intravenous delivery of rifampicin. Pharmazie 2008; 63(11): 806-11.
[PMID: 19069240]
[12]
Halnor VV, Pande VV, Borawake DD, Nagare HS. Nanoemulsion: A novel platform for drug delivery system. J Mat Sci Nanotechnol 2018; 6(1): 104-9.
[13]
Burapapadh K, Takeuchi H, Sriamornsak P. Novel pectin-based nanoparticles prepared from nanoemulsion templates for improving in vitro dissolution and in vivo absorption of poorly water-soluble drug. Eur J Pharm Biopharm 2012; 82(2): 250-61.
[http://dx.doi.org/10.1016/j.ejpb.2012.07.010] [PMID: 22885158]
[14]
Shafiq S, Shakeel F, Talegaonkar S, Ahmad FJ, Khar RK, Ali M. Development and bioavailability assessment of ramipril nanoemulsion formulation. Eur J Pharm Biopharm 2007; 66(2): 227-43.
[http://dx.doi.org/10.1016/j.ejpb.2006.10.014] [PMID: 17127045]
[15]
Choudhury H, Gorain B, Karmakar S, et al. Improvement of cellular uptake, in vitro antitumor activity and sustained release profile with increased bioavailability from a nanoemulsion platform. Int J Pharm 2014; 460(1-2): 131-43.
[http://dx.doi.org/10.1016/j.ijpharm.2013.10.055] [PMID: 24239580]
[16]
Borhade V, Pathak S, Sharma S, Patravale V. Clotrimazole nanoemulsion for malaria chemotherapy. Part I: Preformulation studies, formulation design and physicochemical evaluation. Int J Pharm 2012; 431(1-2): 138-48.
[http://dx.doi.org/10.1016/j.ijpharm.2011.12.040] [PMID: 22227344]
[17]
Gao F, Zhang Z, Bu H, et al. Nanoemulsion improves the oral absorption of candesartan cilexetil in rats: Performance and mechanism. J Control Release 2011; 149(2): 168-74.
[http://dx.doi.org/10.1016/j.jconrel.2010.10.013] [PMID: 20951749]
[18]
Laxmi M, Bhardwaj A, Mehta S, Mehta A. Development and characterization of nanoemulsion as carrier for the enhancement of bioavailability of artemether. Artif Cells Nanomed Biotechnol 2015; 43(5): 334-44.
[http://dx.doi.org/10.3109/21691401.2014.887018] [PMID: 24641773]
[19]
Ma Y, Li H, Guan S. Enhancement of the oral bioavailability of breviscapine by nanoemulsions drug delivery system. Drug Dev Ind Pharm 2015; 41(2): 177-82.
[http://dx.doi.org/10.3109/03639045.2014.947510] [PMID: 25113432]
[20]
Khani S, Keyhanfar F, Amani A. Design and evaluation of oral nanoemulsion drug delivery system of mebudipine. Drug Deliv 2016; 23(6): 2035-43.
[http://dx.doi.org/10.3109/10717544.2015.1088597] [PMID: 26406153]
[21]
Kelmann RG, Kuminek G, Teixeira HF, Koester LS. Carbamazepine parenteral nanoemulsions prepared by spontaneous emulsification process. Int J Pharm 2007; 342(1-2): 231-9.
[http://dx.doi.org/10.1016/j.ijpharm.2007.05.004] [PMID: 17582711]
[22]
Kumar M, Misra A, Pathak K. Formulation and characterization of nanoemulsion of olanzapine for intranasal delivery. PDA J Pharma sci tech. 2009; 63(6): 501-11.
[23]
Singh KK, Vingkar SK. Formulation, antimalarial activity and biodistribution of oral lipid nanoemulsion of primaquine. Int J Pharm 2008; 347(1-2): 136-43.
[http://dx.doi.org/10.1016/j.ijpharm.2007.06.035] [PMID: 17709216]
[24]
Ganta S, Paxton JW, Baguley BC, Garg S. Pharmacokinetics and pharmacodynamics of chlorambucil delivered in parenteral emulsion. Int J Pharm 2008; 360(1-2): 115-21.
[http://dx.doi.org/10.1016/j.ijpharm.2008.04.027] [PMID: 18508212]
[25]
Kumar S, Ali J, Baboota S. Design Expert(®) supported optimization and predictive analysis of selegiline nanoemulsion via the olfactory region with enhanced behavioural performance in Parkinson’s disease. Nanotechnology 2016; 27(43)435101
[http://dx.doi.org/10.1088/0957-4484/27/43/435101] [PMID: 27655136]
[26]
Đorđević SM, Santrač A, Cekić ND, et al. Parenteral nanoemulsions of risperidone for enhanced brain delivery in acute psychosis: Physicochemical and in vivo performances. Int J Pharm 2017; 533(2): 421-30.
[http://dx.doi.org/10.1016/j.ijpharm.2017.05.051] [PMID: 28552767]
[27]
Shen Q, Wang Y, Zhang Y. Improvement of colchicine oral bioavailability by incorporating eugenol in the nanoemulsion as an oil excipient and enhancer. Int J Nanomedicine 2011; 6: 1237-43.
[http://dx.doi.org/10.2147/IJN.S20903] [PMID: 21753875]
[28]
Shukla M, Jaiswal S, Sharma A, et al. A combination of complexation and self-nanoemulsifying drug delivery system for enhancing oral bioavailability and anticancer efficacy of curcumin. Drug Dev Ind Pharm 2017; 43(5): 847-61.
[http://dx.doi.org/10.1080/03639045.2016.1239732] [PMID: 27648633]
[29]
Soliman KA, Ibrahim HK, Ghorab MM. Formulation of avanafil in a solid self-nanoemulsifying drug delivery system for enhanced oral delivery. Eur J Pharm Sci 2016; 93: 447-55.
[http://dx.doi.org/10.1016/j.ejps.2016.08.050] [PMID: 27590128]
[30]
Monteiro LM, Lione VF, do Carmo FA, et al. Development and characterization of a new oral dapsone nanoemulsion system: Permeability and in silico bioavailability studies. Int J Nanomedicine 2012; 7: 5175-82.
[PMID: 23055729]
[31]
Araújo FA, Kelmann RG, Araújo BV, Finatto RB, Teixeira HF, Koester LS. Development and characterization of parenteral nanoemulsions containing thalidomide. Eur J Pharm Sci 2011; 42(3): 238-45.
[http://dx.doi.org/10.1016/j.ejps.2010.11.014] [PMID: 21130164]
[32]
Ganta S, Devalapally H, Amiji M. Curcumin enhances oral bioavailability and anti-tumor therapeutic efficacy of paclitaxel upon administration in nanoemulsion formulation. J Pharm Sci 2010; 99(11): 4630-41.
[http://dx.doi.org/10.1002/jps.22157] [PMID: 20845461]
[33]
Yi J, Zhang Y, Liang R, Zhong F, Ma J. Beta-carotene chemical stability in Nanoemulsions was improved by stabilized with beta-lactoglobulin-catechin conjugates through free radical method. J Agric Food Chem 2015; 63(1): 297-303.
[http://dx.doi.org/10.1021/jf5056024] [PMID: 25514513]
[34]
Modi JD, Patel JK. Nanoemulsion-based gel formulation of aceclofenac for topical delivery. Int J Pharm Pharm Sci Res 2011; 1(1): 6-12.
[35]
Koroleva MY, Yurtov EVE. Nanoemulsions: The properties, methods of preparation and promising applications. Russ Chem Rev 2012; 81(1): 21-43.
[http://dx.doi.org/10.1070/RC2012v081n01ABEH004219]
[36]
Mehta M, Garg M. Proniosomal gel: A promising drug carrier for boswellic acids. J Med Sci 2015; 15(3): 130-134s.
[http://dx.doi.org/10.3923/jms.2015.130.134]
[37]
Kaur G, Mehta SK. Developments of Polysorbate (Tween) based microemulsions: Preclinical drug delivery, toxicity and antimicrobial applications. Int J Pharm 2017; 529(1-2): 134-60.
[http://dx.doi.org/10.1016/j.ijpharm.2017.06.059] [PMID: 28642203]
[38]
Gadhave A. Determination of hydrophilic-lipophilic balance value. Int J Sci Res 2014; 3(4): 573-5.
[39]
Kishore RS, Pappenberger A, Dauphin IB, et al. Degradation of polysorbates 20 and 80: studies on thermal autoxidation and hydrolysis. J Pharm Sci 2011; 100(2): 721-31.
[http://dx.doi.org/10.1002/jps.22290] [PMID: 20803573]
[40]
Yong AP, Islam MA, Hasan NA. Review: Effect of pressure on homogenization. Sigma J Eng Nat Sci 2017; 35(1): 1-22.
[41]
Alligaris S, Plazzotta S, Bot F, Grasselli S, Malchiodi A, Anese M. Nanoemulsion preparation by combining high pressure homogenization and high-power ultrasound at low energy densities. Food Res Int 2016; 83: 25-30.
[http://dx.doi.org/10.1016/j.foodres.2016.01.033]
[42]
Schultz S, Wagner G, Urban K, Ulrich J. High-pressure homogenization as a process for emulsion formation. Chem Eng Technol 2004; 27(4): 361-8.
[http://dx.doi.org/10.1002/ceat.200406111]
[43]
Kheawfu K, Pikulkaew S, Rades T, et al. Development and characterization of clove oil nanoemulsions and self-microemulsifying drug delivery systems. J Drug Deliv Sci Technol 2018; 46: 330-8.
[http://dx.doi.org/10.1016/j.jddst.2018.05.028]
[44]
Yilmaz E, Borchert HH. Effect of lipid-containing, positively charged nanoemulsions on skin hydration, elasticity and erythema-An in vivo study. Int J Pharm 2006; 307(2): 232-8.
[http://dx.doi.org/10.1016/j.ijpharm.2005.10.002] [PMID: 16289984]
[45]
Chen H, Hu X, Chen E, et al. Preparation, characterization, and properties of chitosan films with cinnamaldehyde nanoemulsions. Food Hydrocoll 2016; 61: 662-71.
[http://dx.doi.org/10.1016/j.foodhyd.2016.06.034]
[46]
Linares R, Santos J, Trujillo-Cayado LA. Enhancing rosemary oil-in-water microfluidized nanoemulsion properties through formulation optimization by response surface methodology. LWT 2018; 97: 370-5.
[http://dx.doi.org/10.1016/j.lwt.2018.07.033]
[47]
Goh PS, Ng MH, Choo YM, Amru NB, Chuah CH. Production of nanoemulsions from palm-based tocotrienol rich fraction by microfluidization. Molecules 2015; 20(11): 19936-46.
[http://dx.doi.org/10.3390/molecules201119666] [PMID: 26556328]
[48]
Morsi N, Ibrahim M, Refai H, El Sorogy H. Nanoemulsion-based electrolyte triggered in situ gel for ocular delivery of acetazolamide. Eur J Pharm Sci 2017; 104: 302-14.
[http://dx.doi.org/10.1016/j.ejps.2017.04.013] [PMID: 28433750]
[49]
Soriano-Ruiz JL, Calpena-Capmany AC, Cañadas-Enrich C, et al. Biopharmaceutical profile of a clotrimazole nanoemulsion: Evaluation on skin and mucosae as anticandidal agent. Int J Pharm 2019; 554: 105-15.
[http://dx.doi.org/10.1016/j.ijpharm.2018.11.002] [PMID: 30395953]
[50]
Shi Y, Li H, Li J, et al. Development, optimization and evaluation of emodin loaded nanoemulsion prepared by ultrasonic emulsification. J Drug Deliv Sci Technol 2015; 27: 46-55.
[http://dx.doi.org/10.1016/j.jddst.2015.04.003]
[51]
Komaiko JS, McClements DJ. Formation of food-grade nanoemulsions using low-energy preparation methods: A review of available methods. Compr Rev Food Sci Food Saf 2016; 15(2): 331-52.
[http://dx.doi.org/10.1111/1541-4337.12189]
[52]
Solans C, Solé I. Nano-emulsions: Formation by low-energy methods. Curr Opin Colloid Interface Sci 2012; 17(5): 246-54.
[http://dx.doi.org/10.1016/j.cocis.2012.07.003]
[53]
Lefebvre G, Riou J, Bastiat G, et al. Spontaneous nano-emulsification: Process optimization and modeling for the prediction of the nanoemulsion’s size and polydispersity. Int J Pharm 2017; 534(1-2): 220-8.
[http://dx.doi.org/10.1016/j.ijpharm.2017.10.017] [PMID: 29038063]
[54]
Sugumar S, Ghosh V, Nirmala MJ, Mukherjee A, Chandrasekaran N. Ultrasonic emulsification of eucalyptus oil nanoemulsion: Antibacterial activity against Staphylococcus aureus and wound healing activity in Wistar rats. Ultrason Sonochem 2014; 21(3): 1044-9.
[http://dx.doi.org/10.1016/j.ultsonch.2013.10.021] [PMID: 24262758]
[55]
Ren G, Sun Z, Wang Z, Zheng X, Xu Z, Sun D. Nanoemulsion formation by the phase inversion temperature method using polyoxypropylene surfactants. J Colloid Interface Sci 2019; 540: 177-84.
[http://dx.doi.org/10.1016/j.jcis.2019.01.018] [PMID: 30640065]
[56]
Leong WF, Che Man YB, Lai OM, Long K, Misran M, Tan CP. Optimization of processing parameters for the preparation of phytosterol microemulsions by the solvent displacement method. J Agric Food Chem 2009; 57(18): 8426-33.
[http://dx.doi.org/10.1021/jf901853y] [PMID: 19694442]
[57]
Shakeel F, Baboota S, Ahuja A, Ali J, Aqil M, Shafiq S. Nanoemulsions as vehicles for transdermal delivery of aceclofenac. AAPS PharmSciTech 2007; 8(4): E104-9.
[http://dx.doi.org/10.1208/pt0804104] [PMID: 18181525]
[58]
Shakeel F, Baboota S, Ahuja A, Ali J, Aqil M, Shafiq S. Accelerated stability testing of celecoxib nanoemulsion containing Cremophor-EL. Afr J Pharm Pharmacol 2008; 2: 179-83.
[59]
Schwarz JC, Klang V, Karall S, Mahrhauser D, Resch GP, Valenta C. Optimisation of multiple W/O/W nanoemulsions for dermal delivery of aciclovir. Int J Pharm 2012; 435(1): 69-75.
[http://dx.doi.org/10.1016/j.ijpharm.2011.11.038] [PMID: 22154877]
[60]
Ghosh V, Mukherjee A, Chandrasekaran N. Ultrasonic emulsification of food-grade nanoemulsion formulation and evaluation of its bactericidal activity. Ultrason Sonochem 2013; 20(1): 338-44.
[http://dx.doi.org/10.1016/j.ultsonch.2012.08.010] [PMID: 22954686]
[61]
Başpınar Y, Gündoğdu E, Köksal C, Karasulu E. Pitavastatin containing nanoemulsions: Preparation, characterization and in vitro cytotoxicity. J Drug Deliv Sci Technol 2015; 29: 117-24.
[http://dx.doi.org/10.1016/j.jddst.2015.07.003]
[62]
Kaur K, Kumar R, Mehta SK. Formulation of saponin stabilized nanoemulsion by ultrasonic method and its role to protect the degradation of quercitin from UV light. Ultrason Sonochem 2016; 31: 29-38.
[http://dx.doi.org/10.1016/j.ultsonch.2015.11.017] [PMID: 26964921]
[63]
Meng L, Xia X, Yang Y, et al. Co-encapsulation of paclitaxel and baicalein in nanoemulsions to overcome multidrug resistance via oxidative stress augmentation and P-glycoprotein inhibition. Int J Pharm 2016; 513(1-2): 8-16.
[http://dx.doi.org/10.1016/j.ijpharm.2016.09.001] [PMID: 27596118]
[64]
Fornaguera C, Feiner-Gracia N, Calderó G, García-Celma MJ, Solans C. PLGA nanoparticles from nano-emulsion templating as imaging agents: Versatile technology to obtain nanoparticles loaded with fluorescent dyes. Colloids Surf B Biointerfaces 2016; 147: 201-9.
[http://dx.doi.org/10.1016/j.colsurfb.2016.08.001] [PMID: 27513588]
[65]
Pathan I, Mangle M, Bairagi S. Design and characterization of nanoemulsion for transdermal delivery of meloxicam. Anal Chem Lett 2016; 6(3): 286-95.
[http://dx.doi.org/10.1080/22297928.2016.1209126]
[66]
Ahmad N, Alam MA, Ahmad FJ, et al. Ultrasonication techniques used for the preparation of novel Eugenol-Nanoemulsion in the treatment of wounds healings and anti-inflammatory. J Drug Deliv Sci Technol 2018; 46: 461-73.
[http://dx.doi.org/10.1016/j.jddst.2018.06.003]
[67]
Ghareeb MM, Neamah AJ. Formulation and characterization of nimodipine nanoemulsion as ampoule for oral route. Int J Pharm Sci Res 2017; 8(2): 591-60.
[68]
Chaudhari PM, Kuchekar MA. Development and evaluation of nanoemulsion as a carrier for topical delivery system by box-behnken design. Asian J Pharm Clin Res 2018; 11(8): 286-93.
[http://dx.doi.org/10.22159/ajpcr.2018.v11i8.26359]
[69]
Kumar M, Misra A, Babbar AK, Mishra AK, Mishra P, Pathak K. Intranasal nanoemulsion based brain targeting drug delivery system of risperidone. Int J Pharm 2008; 358(1-2): 285-91.
[http://dx.doi.org/10.1016/j.ijpharm.2008.03.029] [PMID: 18455333]
[70]
Chandrasekaran N. Nanoemulsion formation and characterization by spontaneous emulsification: Investigation of its antibacterial effects on Listeria monocytogenes. Asian J Pharm 2015; 9(1): 23-8.
[http://dx.doi.org/10.4103/0973-8398.150033]
[71]
Barradas TN, Senna JP, Cardoso SA, de Holanda E, Silva KG. Elias MCR. Formulation characterization and in vitro drug release of hydrogel-thickened nanoemulsions for topical delivery of 8-methoxypsoralen. Mater Sci Eng C 2018; 92: 245-53.
[http://dx.doi.org/10.1016/j.msec.2018.06.049] [PMID: 30184748]
[72]
Özdemir S, Celik B, Sümer E, Acar ET, Üner M. Eplerenone nanoemulsions for treatment of hypertension. Part II: Physical stability assessment and in vivo study. J Drug Deliv Sci Technol 2018; 45: 287-95.
[http://dx.doi.org/10.1016/j.jddst.2018.03.014]
[73]
Fofaria NM, Qhattal HSS, Liu X, Srivastava SK. Nanoemulsion formulations for anti-cancer agent piplartine-Characterization, toxicological, pharmacokinetics and efficacy studies. Int J Pharm 2016; 498(1-2): 12-22.
[http://dx.doi.org/10.1016/j.ijpharm.2015.11.045] [PMID: 26642946]
[74]
Đorđević SM, Radulović TS, Cekić ND, et al. Experimental design in formulation of diazepam nanoemulsions: Physicochemical and pharmacokinetic performances. J Pharm Sci 2013; 102(11): 4159-72.
[http://dx.doi.org/10.1002/jps.23734] [PMID: 24114833]
[75]
Alkilani AZ, Hamed R, Al-Marabeh S, Kamal A, Abu-Huwaij R, Hamad I. Nanoemulsion-based film formulation for transdermal delivery of carvedilol. J Drug Deliv Sci Technol 2018; 46: 122-8.
[http://dx.doi.org/10.1016/j.jddst.2018.05.015]
[76]
Nikam TH, Patil MP, Patil SS, et al. Nanoemulsion: A brief review on development and application in Parenteral Drug Delivery. Adv Pharm J 2018; 3(2): 43-54.
[http://dx.doi.org/10.31024/apj.2018.3.2.2]
[77]
Bhosale RR, Osmani RA, Ghodake PP, et al. Nanoemulsion: A review on novel profusion in advanced drug delivery. Indian J Pharm Biol Res 2014; 2(1): 122-7.
[http://dx.doi.org/10.30750/ijpbr.2.1.19]
[78]
Carmona-Moran CA, Zavgorodnya O, Penman AD, et al. Development of gellan gum containing formulations for transdermal drug delivery: Component evaluation and controlled drug release using temperature responsive nanogels. Int J Pharm 2016; 509(1-2): 465-76.
[http://dx.doi.org/10.1016/j.ijpharm.2016.05.062] [PMID: 27260133]
[79]
Muzaffar F, Singh UK, Chauhan L. Review on microemulsion as futuristic drug delivery. Int J Pharm Pharm Sci 2013; 5(3): 39-53.
[80]
Vishwakarma AK, Panda PD, Verma NK, et al. Nanoemulsion: An Innovative Drug Delivery- A Review. Eur J Biomed Pharm Sci 2018; 5(4): 952-8.
[81]
Shakeel F, Ramadan W, Gargum HM, Singh R. Preparation and in vivo evaluation of indomethacin loaded true nanoemulsions. Sci Pharm 2010; 78(1): 47-56.
[http://dx.doi.org/10.3797/scipharm.0911-04] [PMID: 21179369]
[82]
Majeed A, Bashir R, Maqbool M. Preparation, characterization and applications of nanoemulsions: An Insight. J Drug Deliv Ther 2019; 9(2): 520-7.
[http://dx.doi.org/10.22270/jddt.v9i2.2410]
[83]
Brito LA, Chan M, Shaw CA, et al. A cationic nanoemulsion for the delivery of next-generation RNA vaccines. Mol Ther 2014; 22(12): 2118-29.
[http://dx.doi.org/10.1038/mt.2014.133] [PMID: 25027661]
[84]
Silva HD, Cerqueira MÂ, Vicente AA. Nanoemulsions for food applications: Development and characterization. Food Bioprocess Technol 2012; 5(3): 854-67.
[http://dx.doi.org/10.1007/s11947-011-0683-7]
[85]
Thiruvengadam M, Rajakumar G, Chung IM. Nanotechnology: Current uses and future applications in the food industry. 3 Biotech. 2018; 8(1): 74.
[86]
Rani D, Saxena R, Nayak B, Srivastava S. Cloning and expression of truncated ORF2 as a vaccine candidate against hepatitis E virus. 3 Biotech. 2018; 8(10): 414.
[87]
Li X, Qi J, Xie Y, et al. Nanoemulsions coated with alginate/chitosan as oral insulin delivery systems: Preparation, characterization, and hypoglycemic effect in rats. Int J Nanomedicine 2013; 8: 23-32.
[PMID: 23293517]
[88]
Mohamadi SS, Abdolalizadeh J, Zeinali Heris S. Ultrasonic/ sonochemical synthesis and evaluation of nanostructured oil in water emulsions for topical delivery of protein drugs. Ultrason Sonochem 2019; 55: 86-95.
[http://dx.doi.org/10.1016/j.ultsonch.2019.03.018] [PMID: 31084795]
[89]
Yang Y, Chen L, Sun HW, et al. Epitope-loaded nanoemulsion delivery system with ability of extending antigen release elicits potent Th1 response for intranasal vaccine against Helicobacter pylori. J Nanobiotechnology 2019; 17(1): 6.
[http://dx.doi.org/10.1186/s12951-019-0441-y] [PMID: 30660182]
[90]
Yao T, Asayama Y. Animal-cell culture media: History, characteristics, and current issues. Reprod Med Biol 2017; 16(2): 99-117.
[http://dx.doi.org/10.1002/rmb2.12024] [PMID: 29259457]
[91]
Ichikawa H, Watanabe T, Tokumitsu H, Fukumori Y. Formulation considerations of gadolinium lipid nanoemulsion for intravenous delivery to tumors in neutron-capture therapy. Curr Drug Deliv 2007; 4(2): 131-40.
[http://dx.doi.org/10.2174/156720107780362294] [PMID: 17456032]
[92]
Khandavilli S, Panchagnula R. Nanoemulsions as versatile formulations for paclitaxel delivery: Peroral and dermal delivery studies in rats. J Invest Dermatol 2007; 127(1): 154-62.
[http://dx.doi.org/10.1038/sj.jid.5700485] [PMID: 16858422]
[93]
Fang JY, Hung CF, Hua SC, Hwang TL. Acoustically active perfluorocarbon nanoemulsions as drug delivery carriers for camptothecin: Drug release and cytotoxicity against cancer cells. Pharm Res 1998; 10: 105-11.
[94]
Mohanachandran PS, Sindhumol PG, Kiran TS. Enhancement of solubility and dissolution rate: An Overview. Pharm Glob 2010.
[95]
Mehta M, Dureja H, Garg M. Development and optimization of boswellic acid-loaded proniosomal gel. Drug Deliv 2016; 23(8): 3072-81.
[http://dx.doi.org/10.3109/10717544.2016.1149744] [PMID: 26953869]
[96]
Mehta M, Satija S, Nanda A, Garg M. Nanotechnologies for boswellic acids. Am J Drug Discov Dev 2014.
[http://dx.doi.org/10.3923/ajdd.2014.1.11]
[97]
Chellappan DK, Yee NJ, Singh BJKAJS, et al. Formulation and characterization of glibenclamide and quercetin-loaded chitosan nanogels targeting skin permeation. Ther Deliv 2019; 10(5): 281-93.
[http://dx.doi.org/10.4155/tde-2019-0019] [PMID: 31094299]
[98]
Soon L, Ng PQ, Chellian J, et al. Therapeutic potential of Artemisia vulgaris: An insight into underlying immunological mechanisms. J Environ Pathol Toxicol Oncol 2019; 38(3): 205-16.
[http://dx.doi.org/10.1615/JEnvironPatholToxicolOncol.2019029397] [PMID: 31679308]
[99]
Niu M, Lu Y, Hovgaard L, et al. Hypoglycemic activity and oral bioavailability of insulin-loaded liposomes containing bile salts in rats: The effect of cholate type, particle size and administered dose. Eur J Pharm Biopharm 2012; 81(2): 265-72.
[http://dx.doi.org/10.1016/j.ejpb.2012.02.009] [PMID: 22369880]
[100]
Allison AG, Gregoriadis G. Liposomes as immunological adjuvants. Nature 1974; 252(5480): 252.
[http://dx.doi.org/10.1038/252252a0] [PMID: : 4424229]
[101]
Jadon PS, Gajbhiye V, Jadon RS, Gajbhiye KR, Ganesh N. Enhanced oral bioavailability of griseofulvin via niosomes. AAPS PharmSciTech 2009; 10(4): 1186-92.
[http://dx.doi.org/10.1208/s12249-009-9325-z] [PMID: 19856107]
[102]
Zhuang CY, Li N, Wang M, et al. Preparation and characterization of vinpocetine loaded Nanostructured Lipid Carriers (NLC) for improved oral bioavailability. Int J Pharm 2010; 394(1-2): 179-85.
[http://dx.doi.org/10.1016/j.ijpharm.2010.05.005] [PMID: 20471464]
[103]
Luo Y, Chen D, Ren L, Zhao X, Qin J. Solid lipid nanoparticles for enhancing vinpocetine’s oral bioavailability. J Control Release 2006; 114(1): 53-9.
[http://dx.doi.org/10.1016/j.jconrel.2006.05.010] [PMID: 16828192]
[104]
Wang Y, Zhang D, Liu Z, et al. In vitro and in vivo evaluation of silybin nanosuspensions for oral and intravenous delivery. Nanotechnology 2010; 21(15)155104
[http://dx.doi.org/10.1088/0957-4484/21/15/155104] [PMID: 20332565]
[105]
Sun M, Gao Y, Guo C, et al. Enhancement of transport of curcumin to brain in mice by poly(n-butylcyanoacrylate) nanoparticle. J Nanopart Res 2010; 12(8): 3111-22.
[http://dx.doi.org/10.1007/s11051-010-9907-4]
[106]
Wadhwa R, Pandey P, Gupta G, et al. Emerging complexity and the need for advanced drug delivery in targeting Candida species. Curr Top Med Chem 2019; 19(28): 2593-609.
[http://dx.doi.org/10.2174/1568026619666191026105308] [PMID: 31746290]
[107]
McClements DJ, Decker EA, Weiss J. Emulsion-based delivery systems for lipophilic bioactive components. J Food Sci 2007; 72(8): R109-24.
[http://dx.doi.org/10.1111/j.1750-3841.2007.00507.x] [PMID: 17995616]
[108]
Ahmed K, Li Y, McClements DJ, Xiao H. Nanoemulsion- and emulsion-based delivery systems for curcumin: Encapsulation and release properties. Food Chem 2012; 132(2): 799-807.
[http://dx.doi.org/10.1016/j.foodchem.2011.11.039]
[109]
Kuo F, Subramanian B, Kotyla T, Wilson TA, Yoganathan S, Nicolosi RJ. Nanoemulsions of an anti-oxidant synergy formulation containing gamma tocopherol have enhanced bioavailability and anti-inflammatory properties. Int J Pharm 2008; 363(1-2): 206-13.
[http://dx.doi.org/10.1016/j.ijpharm.2008.07.022] [PMID: 18718513]
[110]
Singh H, Satija S, Kaur H, et al. Novel drug delivery approaches for guggul. Plant Arch 2019; 19: 983-93.
[111]
Mehta MN, Pandey P, Mahajan S, Satija S. Gastro retentive drug delivery systems: An overview. Res J Pharm Technol 2018; 11(5): 2157-60.
[http://dx.doi.org/10.5958/0974-360X.2018.00398.0]
[112]
Huang J. Compositions for nanoemulsion delivery systems. US Patent 10251837B2 2019.
[113]
Fattom AI, Simon J, Baker JR, et al. Herpes simplex virus nanoemulsion vaccine. US Patent 10206996B2 2019.
[114]
Oh H, Smith SD, Gartstein V. Method of making an amino silicone nanoemulsion. US Patent 10182980B2 2019.
[115]
Lee JB, Park CH, Ryoo HC. Method for preparing nanoemulsion. US Patent 9687423B2, 2017.
[116]
Ciotti S. Methods and compositions for nanoemulsion vaccine formulations. US Patent 2017007689A1, 2017.
[117]
Liu H, Zhang B. Nanoparticles and nanoemulsion. US Patent 9833403 B2, 2017.
[118]
Ganta S, Coleman TP. Nanoemulsion of hydrophobic platinum derivatives. US Patent 2016166507A1 2016.
[119]
Andrecola P. Biodegradable non-acidic oil-in-water nanoemulsion. US Patent 2105119300A1, 2015.
[120]
Quintero L, Clark DE, Mckellar AJ. Nanoemulsion. US Patent 8822385B2, 2014.
[121]
Quintero L, Clark DE, Mckellar AJ. Nanoemulsion vaccines. US Patent 2012000327, 2012.
[122]
Elbayoumi TA, Peoria AZ, Kuo F, et al. Nanoemulsion formulation for direct delivery. US Patent 004505 A1 2011.
[123]
Baker JR. Nanoemulsion compositions having anti-inflammatory activity. US Patent 20070036831A1 2007.
[124]
Young K. Nanoemulsion the use thereof, the preparation method thereof. WO Patent 2006028339A1, 2006
[125]
Qeumin E. Translucent nanoemulsion, production method, and use thereof in the cosmetic, dermatological and ophthalmological fields. US Patent 6902737B2 2005.
[126]
Baker JR. Jr, Hamouda T, Myc A. Antimicrobial nanoemulsion composition and methods. AU Patent 20022350587A2, 2003. 2007.
[127]
Simonnet JT, Sonneville O, Legret S. Nanoemulsion based on ethylene oxide and propylene oxide block copolymers and its uses in the cosmetics, dermatological and ophthalmological fields. US Patent 6464990B2, 2002.
[128]
Lacy JE, Embleton JK. Delivery systems for hydrophobic drugs. US Patent 5645856 1997.
[129]
Curtet B, Cote M, Talant E, et al. Novel dosage form of fenofibrate.US Patent 5895726 1990.

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