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Current Pharmaceutical Biotechnology

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ISSN (Print): 1389-2010
ISSN (Online): 1873-4316

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General Research Article

Oleophylic Nanospheres Self-Assembly by Emulsion Technique Utilizing the Automatic Nanoscalar Interfacial Alternation (ANIAE)

Author(s): Hao Ran, Weibin Liu*, Xin Pan*, Chuanbin Wu*, Guilan Quan, Ying Huang and Yingtong Cui

Volume 22, Issue 1, 2021

Published on: 02 June, 2020

Page: [182 - 190] Pages: 9

DOI: 10.2174/1389201021666200602134054

Price: $65

Abstract

Background: The administration of many pharmaceutical active ingredients is often performed by the injection of an aqueous-based solution. Numerous active ingredients are however, insoluble in water, which complicates their administration and restricts their efficacy.

Objective: The current solutions are hindered by both, a time-consuming manufacturing process and unsuitability for hydrophilic and hydrophobic materials.

Methods: Emulsions of oleophilic active ingredients and polyprotein microspheres are an important step to overcome insolubility issues.

Results: Polyprotein microspheres offer a versatile modifiable morphology, thermal responsivity, and size variation, which allows for the protection and release of assembled biomaterials. In addition, nanospheres present promising cell phagocytosis outcomes in vivo.

Conclusion: In this research, a reproducible multifunctional approach, to assemble nanospheres in one step, using a technique termed “automatic nanoscalar interfacial alternation in emulsion” (ANIAE) was developed, incorporating a thermally controlled release mechanism for the assembled target active ingredients. These results demonstrate a viable, universal, multifunctional principal for the pharmaceutical industry.

Keywords: Self-Assembly, oleophilic nanospheres, polyprotein, ANIAE, thermally controlled release, assembled biomaterials.

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