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Review Article

环氧合酶(COX)天然产物抑制剂的研究现状与展望

卷 28, 期 10, 2021

发表于: 02 June, 2020

页: [1877 - 1905] 页: 29

弟呕挨: 10.2174/0929867327666200602131100

价格: $65

摘要

背景：一些临床使用的COX-1和COX-2抑制剂药物分别有严重的副作用，如胃肠道溃疡和心血管紊乱。天然产物结构多样，作为药物发现过程中先导分子的潜在来源一直吸引着化学家/药物化学家的注意。抑制COX-2的天然产物对结肠癌、乳腺癌和前列腺癌等多种癌症也具有潜在的化学预防作用。 方法：采用各种体外、体内和硅标准化方法，评价从植物、微生物和海洋来源分离的不同次生代谢产物COX抑制特性。 结果：我们早前曾在1995-2005年和2006年详细报道过COX的天然产物抑制剂。在这篇综述中，我们报告了2006年至2019年期间COX的158种天然产物抑制剂，它们属于各种次生代谢类，如生物碱、萜类、多酚类，如黄酮类、色酮类、香豆素类、木酚素类、蒽醌类、萘类、姜黄素类、二芳基庚烷类以及植物和海洋来源的杂类化合物。进一步的结构活性关系(SAR)研究可能的先导物也包括在文章中。 结论：COX抑制剂为抗炎药物的发现和开发提供了潜在的先导分子来源。COX的天然产物和半合成抑制剂的合成可能为研究人员提供有价值的信息，他们正在从天然来源中寻找可能的先导分子，以便进行进一步的临床前和临床研究。

关键词: 环氧合酶-1 (COX-1)，环氧合酶-2 (COX-2)，天然产物COX抑制剂，抗炎活性，癌症，次生代谢产物

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