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Letters in Organic Chemistry

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ISSN (Print): 1570-1786
ISSN (Online): 1875-6255

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Research Article

Synthesis of 4,6-Dimethylpyrimidine 2-Thiosubstituted Derivatives and Their Preliminary Biological Evaluation

Author(s): Aleksandr P. Yengoyan*, Elen N. Hambardzumyan, Asya S. Vorskanyan and Lusya V. Shahbazyan

Volume 18, Issue 4, 2021

Published on: 01 June, 2020

Page: [311 - 317] Pages: 7

DOI: 10.2174/1570178617999200601165334

Price: $65

Abstract

Based on 4,6-dimethylpyrimidine-2-thiol hydrochloride a series of its novel S-substituted derivatives including bi- and tricyclic heterosystems with a combination of azines and pyrazole cycles in the molecule were synthesized. The preliminary biological screening has shown that the obtained compounds have a pronounced plants growth-stimulating activity, which is a new property for these heterosystems. This fact indicates the prospectivity of further development of synthesized systems for the search for new plants growth stimulators.

Keywords: 4, 6-dimethylpyrimidine-2-thiol, 4, 6-dimethylpyrimidine-2-thioalkylamides, 2-S-substituted 4, 6-dimethylpyrimidines, 2-substituted azinyl-thiopyrimidines, plant growth stimulating activity.

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