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当代肿瘤药物靶点

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ISSN (Print): 1568-0096
ISSN (Online): 1873-5576

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Mini-Review Article

靶向MUC15蛋白在癌症中的作用：分子机制和治疗前景。

卷 20, 期 9, 2020

页: [647 - 653] 页: 7

弟呕挨: 10.2174/1568009620666200601140639

价格: $65

摘要

MUC15是粘蛋白家族的成员，是一种高度糖基化的跨膜蛋白，主要功能是润滑表面，在上皮细胞上建立选择性分子屏障并介导信号转导。 MUC15的异常表达在包括恶性肿瘤在内的多种疾病的进展中起着至关重要的作用。 MUC15已被鉴定为肿瘤抑制因子，但目前的证据表明它在不同类型的癌症中均作为癌基因发挥作用。 已显示MUC15参与癌症的发展，并影响细胞生长，粘附，侵袭，转移和免疫免疫调节。 然而，尚未完全阐明MUC15在肿瘤发展中的确切作用。 在这里，我们系统地总结了MUC15在癌症中的结构和功能，并讨论了其在癌症治疗中的潜在作用。

关键词: 肿瘤MUC15，肿瘤增殖，转移，肿瘤治疗，糖基化跨膜蛋白，信号转导。

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