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当代阿耳茨海默病研究

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ISSN (Print): 1567-2050
ISSN (Online): 1875-5828

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Research Article

老年人的前-后功能连接性断开伴主观记忆障碍和轻度记忆障碍

卷 17, 期 4, 2020

页: [373 - 381] 页: 9

弟呕挨: 10.2174/1567205017666200525015017

价格: $65

摘要

背景:主观记忆障碍(SMI)可能极大地增加阿尔茨海默病(AD)的风险。充分了解SMI的神经机制，对AD的早期干预有一定的指导意义。 方法:对23例健康对照(HC)、22例重度精神病(SMI)和24例遗忘型轻度认知障碍(aMCI)患者进行神经心理综合评估和静息状态功能磁共振扫描。分别比较了从感兴趣区域到全脑的默认模式网络(DMN)和功能连接(FC)的差异。 结果:HC和SMI患者楔前叶区域的连通性明显高于aMCI患者。然而，从这一区域到全脑，SMI和aMCI受试者的右侧前扣带、左侧额上回和左侧内侧额上回的FC明显低于HC。此外，FC变化与参与者的认知功能下降显著相关。 结论:我们的研究表明重度精神病人有相对完整的DMN连接，但受损的FC之间的前和后脑。研究结果表明，在重度精神病患者中，长距离FC比短距离FC更容易受到伤害。

关键词: 主观记忆障碍

« Previous Next »
[1]
Sperling RA, Aisen PS, Beckett LA, et al. Toward defining the preclinical stages of Alzheimer’s disease: recommendations from the National Institute on Aging-Alzheimer’s Association workgroups on diagnostic guidelines for Alzheimer’s disease. Alzheimers Dement 2011; 7(3): 280-92.
[http://dx.doi.org/10.1016/j.jalz.2011.03.003] [PMID: 21514248]
[2]
Jessen F, Amariglio RE, van Boxtel M, et al. Subjective Cognitive Decline Initiative (SCD-I) Working Group. A conceptual framework for research on subjective cognitive decline in preclinical Alzheimer’s disease. Alzheimers Dement 2014; 10(6): 844-52.
[http://dx.doi.org/10.1016/j.jalz.2014.01.001] [PMID: 24798886]
[3]
Stewart R, Godin O, Crivello F, et al. Subjective cognitive decline in preclinical Alzheimer’s disease.Longitudinal neuroimaging correlates of subjective memory impairment: 4-year prospective community study. Br J Psychiatry 2011; 198(3): 199-205.
[http://dx.doi.org/10.1192/bjp.bp.110.078683] [PMID: 21357878]
[4]
Stewart R, Godin o, Crivello F, et al. Longitudinal neuroimaging correlates of subjective memory impairment: 4-year prospective community study. Brit J Psychiat 198(3): 199-205.
[5]
Ryu SY, Lim EY, Na S, et al. Hippocampal and entorhinal structures in subjective memory impairment:A combined MRI volumetric and DTI study. Int Psychogeriatr 2017; 29(5): 785-92.
[http://dx.doi.org/10.1017/S1041610216002349] [PMID: 28067183]
[6]
Schultz SA, Oh JM, Koscik RL, et al. Subjective memory complaints, cortical thinning, and cognitive dysfunction in middle-aged adults at risk for AD. Alzheimers Dement (Amst) 2015; 1(1): 33-40.
[http://dx.doi.org/10.1016/j.dadm.2014.11.010] [PMID: 25938132]
[7]
Li XY, Tang ZC, Sun Y, Tian J, Liu ZY, Han Y. White matter degeneration in subjective cognitive decline: a diffusion tensor imaging study. Oncotarget 2016; 7(34): 54405-14.
[http://dx.doi.org/10.18632/oncotarget.10091] [PMID: 27384675]
[8]
Shu N, Wang X, Bi Q, Zhao T, Han Y. Disrupted topologic efficiency of white matter structural connectome in individuals with subjective cognitive decline. Radiology 2018; 286(1): 229-38.
[PMID: 28799862]
[9]
Jeong HS, Park JS, Song IU, Chung YA, Rhie SJ. Changes in cognitive function and brain glucose metabolism in elderly women with subjective memory impairment: A 24-month prospective pilot study. Acta Neurol Scand 2017; 135(1): 108-14.
[http://dx.doi.org/10.1111/ane.12569] [PMID: 26861213]
[10]
Snitz BE, Lopez OL, McDade E, et al. Amyloid-β imaging in older adults presenting to a memory clinic with subjective cognitive decline: A pilot study. J Alzheimers Dis 2015; 48(1): S151-9.
[http://dx.doi.org/10.3233/JAD-150113] [PMID: 26402082]
[11]
Delbeuck X, Van der Linden M, Collette F. Alzheimer’s disease as a disconnection syndrome? Neuropsychol Rev 2003; 13(2): 79-92.
[http://dx.doi.org/10.1023/A:1023832305702] [PMID: 12887040]
[12]
Sheline YI, Raichle ME. Resting state functional connectivity in preclinical Alzheimer’s disease. Biol Psychiatry 2013; 74(5): 340-7.
[http://dx.doi.org/10.1016/j.biopsych.2012.11.028] [PMID: 23290495]
[13]
Dillen KN, Jacobs HI, Kukolja J, et al. Functional disintegration of the default mode network in prodromal Alzheimer’s disease. Oncotarget 2017;; 7(34):: 54405--14.
[http://dx.doi.org/10.3233/JAD-161120]
[14]
Hafkemeijer A, Altmann-Schneider I, Oleksik AM, et al. Increased functional connectivity and brain atrophy in elderly with subjective memory complaints. Brain Connect 2013; 3(4): 353-62.
[http://dx.doi.org/10.1089/brain.2013.0144] [PMID: 23627661]
[15]
Wang Y, Risacher SL, West JD, et al. Altered default mode network connectivity in older adults with cognitive complaints and amnestic mild cognitive impairment. J Alzheimers Dis 2013; 35(4): 751-60.
[http://dx.doi.org/10.3233/JAD-130080] [PMID: 23481685]
[16]
Liu Y, Yu C, Zhang X, et al. Impaired long distance functional connectivity and weighted network architecture in Alzheimer’s disease. Cereb Cortex 2014; 24(6): 1422-35.
[http://dx.doi.org/10.1093/cercor/bhs410] [PMID: 23314940]
[17]
Zhang H-Y, Wang S-J, Xing J, et al. Detection of PCC functional connectivity characteristics in resting-state fMRI in mild Alzheimer’s disease. Behav Brain Res 2009; 197(1): 103-8.
[http://dx.doi.org/10.1016/j.bbr.2008.08.012] [PMID: 18786570]
[18]
Dillen KNH, Jacobs HIL, Kukolja J, et al. Aberrant functional connectivity differentiates retrosplenial cortex from posterior cingulate cortex in prodromal Alzheimer’s disease. Neurobiol Aging 2016; 44: 114-26.
[http://dx.doi.org/10.1016/j.neurobiolaging.2016.04.010] [PMID: 27318139]
[19]
Yasuno F, Kazui H, Yamamoto A, et al. Resting-state synchrony between the retrosplenial cortex and anterior medial cortical structures relates to memory complaints in subjective cognitive impairment. Neurobiol Aging 2015; 36(6): 2145-52.
[http://dx.doi.org/10.1016/j.neurobiolaging.2015.03.006] [PMID: 25862421]
[20]
Li X, Ma C, Zhang J, et al. Beijing Ageing Brain Rejuvenation Initiative. Prevalence of and potential risk factors for mild cognitive impairment in community-dwelling residents of Beijing. J Am Geriatr Soc 2013; 61(12): 2111-9.
[http://dx.doi.org/10.1111/jgs.12552] [PMID: 24479143]
[21]
Petersen RC, Smith GE, Waring SC, Ivnik RJ, Tangalos EG, Kokmen E. Mild cognitive impairment: Clinical characterization and outcome. Arch Neurol 1999; 56(3): 303-8.
[http://dx.doi.org/10.1001/archneur.56.3.303] [PMID: 10190820]
[22]
Rosenberg SJ, Ryan JJ, Prifitera A. rey auditory-verbal learning test performance of patients with and without memory impairment. J Clin Psychol 1984; 40(3): 785-7.
[http://dx.doi.org/10.1002/1097-4679(198405)40:3<785:AID-JCLP2270400325>3.0.CO;2-4] [PMID: 6746989]
[23]
Shin M-S, Park S-Y, Park S-R, Seol S-H, Kwon JS. Clinical and empirical applications of the Rey-Osterrieth complex figure test. Nat Protoc 2006; 1(2): 892-9.
[http://dx.doi.org/10.1038/nprot.2006.115] [PMID: 17406322]
[24]
Guo Q, Zhao Q, Chen M, Ding D, Hong Z. A comparison study of mild cognitive impairment with 3 memory tests among Chinese individuals. Alzheimer Dis Assoc Disord 2009; 23(3): 253-9.
[http://dx.doi.org/10.1097/WAD.0b013e3181999e92]
[25]
Zhao QD, Ding Q, Guo JA, Mortimer CI, Salmon CD. Shanghai community brain health initiative pilot study: Neuropsychological results Alzheimer’s Dementia. J Alzheimer’s Assoc 2009; 5(4): P14-5.
[26]
Greicius MD, Srivastava G, Reiss AL, Menon V. Default-mode network activity distinguishes Alzheimer’s disease from healthy aging: Evidence from functional MRI. Proc Natl Acad Sci USA 2004; 101(13): 4637-42.
[http://dx.doi.org/10.1073/pnas.0308627101] [PMID: 15070770]
[27]
Utevsky AV, Smith DV, Huettel SA. Precuneus is a functional core of the default-mode network. J Neurosci 2014; 34(3): 932-40.
[http://dx.doi.org/10.1523/JNEUROSCI.4227-13.2014] [PMID: 24431451]
[28]
López-Sanz D, Garcés P. Maestú, Network disruption in the preclinical stages of Alzheimer’s disease: From subjective cognitive decline to mild cognitive impairment. Int J Neural Syst 2017; 27(8)1750041
[http://dx.doi.org/10.1142/S0129065717500411] [PMID: 28958179]
[29]
Rabin LA, Chi SY, Wang C, Fogel J, Kann SJ, Aronov A. Prospective memory on a novel clinical task in older adults with mild cognitive impairment and subjective cognitive decline. Neuropsychol Rehabil 2014; 24(6): 868-93.
[http://dx.doi.org/10.1080/09602011.2014.915855] [PMID: 24875614]
[30]
Garcia-Ptacek S, Eriksdotter M, Jelic V, Porta-Etessam J, Kåreholt I, Manzano Palomo S. Subjective cognitive impairment: Towards early identification of Alzheimer disease. Neurologia 2016; 31(8): 562-71.
[http://dx.doi.org/10.1016/j.nrl.2013.02.007] [PMID: 23601758]
[31]
Burmester B, Leathem J, Merrick P. Subjective cognitive complaints and objective cognitive function in aging: A systematic review and meta-analysis of recent cross-sectional findings. Neuropsychol Rev 2016; 26(4): 376-93.
[http://dx.doi.org/10.1007/s11065-016-9332-2] [PMID: 27714573]
[32]
Kurt P, Yener G, Oguz M. Impaired digit span can predict further cognitive decline in older people with subjective memory complaint: A preliminary result. Aging Ment Health 2011; 15(3): 364-9.
[http://dx.doi.org/10.1080/13607863.2010.536133] [PMID: 21491221]
[33]
Pasquini L, Benson G, Grothe MJ, et al. Alzheimer’s Disease Neuroimaging Initiative. Individual correspondence of amyloid-β and intrinsic connectivity in the posterior default mode network across stages of Alzheimer’s disease. J Alzheimers Dis 2017; 58(3): 763-73.
[http://dx.doi.org/10.3233/JAD-170096] [PMID: 28482640]
[34]
Tao W, Li X, Zhang J, Chen Y, Ma C, Liu Z, et al. Inflection point in course of mild cognitive impairment: Increased functional connectivity of default mode network. J Alzheimer's Dis 2017; 60(2): 679-90.
[35]
Fransson P, Marrelec G. The precuneus/posterior cingulate cortex plays a pivotal role in the default mode network: Evidence from a partial correlation network analysis. Neuroimage 2008; 42(3): 1178-84.
[PMID: 18598773]
[36]
Viviano RP, Hayes JM, Pruitt PJ, et al. Aberrant memory system connectivity and working memory performance in subjective cognitive decline. Neuroimage 2019; 185: 556-64.
[http://dx.doi.org/10.1016/j.neuroimage.2018.10.015] [PMID: 30308246]
[37]
Schmidt SA, Carpenter-Thompson J, Husain FT. Connectivity of precuneus to the default mode and dorsal attention networks: A possible invariant marker of long-term tinnitus. Neuroimage Clin 2017; 16: 196-204.
[http://dx.doi.org/10.1016/j.nicl.2017.07.015] [PMID: 28794980]
[38]
Cavanna AE, Trimble MR. The precuneus: A review of its functional anatomy and behavioural correlates. Brain 2006; 129(Pt 3): 564-83.
[http://dx.doi.org/10.1093/brain/awl004] [PMID: 16399806]
[39]
Dennis EL, Thompson PM. Functional brain connectivity using fMRI in aging and Alzheimer’s disease. Neuropsychol Rev 2014; 24(1): 49-62.
[http://dx.doi.org/10.1007/s11065-014-9249-6] [PMID: 24562737]
[40]
Mutlu J, Landeau B, Tomadesso C, et al. Connectivity disruption, atrophy, and hypometabolism within posterior cingulate networks in Alzheimer’s disease. Front Neurosci 2016; 10: 582.
[http://dx.doi.org/10.3389/fnins.2016.00582] [PMID: 28066167]
[41]
Grajski KA, Bressler SL. Differential default-mode network functional connectivity and morphometric changes in Alzheimer’s disease. bioRxiv 2017; 232: 165.
[42]
Grothe MJ, Barthel H, Sepulcre J, Dyrba M, Sabri O, Teipel SJ. Alzheimer’s Disease Neuroimaging Initiative. In vivo staging of regional amyloid deposition. Neurology 2017; 89(20): 2031-8.
[http://dx.doi.org/10.1212/WNL.0000000000004643] [PMID: 29046362]
[43]
Larivière S, Lavigne KM, Woodward TS, Gerretsen P, Graff-Guerrero A, Menon M. Altered functional connectivity in brain networks underlying self-referential processing in delusions of reference in schizophrenia. Psychiat Res Neuroimag 2017; 263: 32-43.
[http://dx.doi.org/10.1016/j.pscychresns.2017.03.005] [PMID: 28315577]
[44]
Qin P, Northoff G. How is our self related to midline regions and the default-mode network? Neuroimage 2011; 57(3): 1221-33.
[http://dx.doi.org/10.1016/j.neuroimage.2011.05.028] [PMID: 21609772]
[45]
Kolling N, Wittmann MK, Behrens TE, Boorman ED, Mars RB, Rushworth MF. Value, search, persistence and model updating in anterior cingulate cortex. Nat Neurosci 2016; 19(10): 1280-5.
[http://dx.doi.org/10.1038/nn.4382] [PMID: 27669988]
[46]
Franzmeier N, Duering M, Weiner M, Dichgans M, Ewers M. Alzheimer’s Disease Neuroimaging Initiative (ADNI). Left frontal cortex connectivity underlies cognitive reserve in prodromal Alzheimer disease. Neurology 2017; 88(11): 1054-61.
[http://dx.doi.org/10.1212/WNL.0000000000003711] [PMID: 28188306]

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