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当代阿耳茨海默病研究

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ISSN (Print): 1567-2050
ISSN (Online): 1875-5828

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Research Article

缺乏身体活动容易增加心血管风险和认知能力受损

卷 17, 期 4, 2020

页: [365 - 372] 页: 8

弟呕挨: 10.2174/1567205017666200522205646

价格: $65

摘要

背景:久坐的生活方式是一个重要的公共健康问题。增加2型糖尿病(DM2)和全身性动脉高血压(SAH)的发病率，进而损害身心健康。事实上，葡萄糖代谢紊乱是阿尔茨海默氏症的特征，通常被称为3型糖尿病。 目的:本研究的目的是评估DM2和/或SAH患者的活动水平、身体组成、心血管风险和认知状况。本研究为横断面设计。 方法:样本120人，男性35%，女性65%，平均年龄64±9岁，60±11岁。研究人员评估了各种参数，如人体测量变量、计步器记录和简短认知筛查组(BCSB)，后者评估即时记忆、语言流畅性、学习能力、后期记忆和识别能力。卡方检验和费雪精确检验被用于观察男性和女性之间可能的差异。除了Kruskall-Wallis，在SAH患者之间的比较;DM2和SAH + DM2。 结果:在参与该项目的人员中发现了高比率的身体缺乏活动。女性的特征是身体脂肪增加，而男性表现出内脏脂肪过剩。BCSB表现出语言流畅性下降，记忆力和识别能力下降，女性表现出明显更差的结果。 结论:低水平的日常体育活动与肥胖、心血管风险升高和认知功能障碍明显相关。

关键词: 简短认知筛查组(BCSB)

« Previous Next »
[1]
Muriach M, Flores-Bellver M, Romero FJ, Barcia JM. Diabetes and the brain: oxidative stress, inflamemation, and autophagy. Oxid Med Cell Longev 2014; 2014; 102158.
[2]
Milne NT, Bucks RS, Davis WA, et al. Hippocampal atrophy, asymmetry, and cognition in type 2 diabetes mellitus. Brain Behav 2017; 8(1)e00741
[http://dx.doi.org/10.1002/brb3.741] [PMID: 29568674]
[3]
Takeda JRT, Matos TM, de Souza-Talarico JN. Cardiovascular risk factors and cognitive performance in aging. Dement Neuropsychol 2017; 11(4): 442-8.
[http://dx.doi.org/10.1590/1980-57642016dn11-040015] [PMID: 29354226]
[4]
Böhm M, Schumacher H, Leong D, et al. Systolic blood pressure variation and mean heart rate is associated with cognitive dysfunction in patients with high cardiovascular risk. Hypertension 2015; 65(3): 651-61.
[5]
Stanford KI, Goodyear LJ. Exercise and type 2 diabetes: Molecular mechanisms regulating glucose uptake in skeletal muscle. Adv Physiol Educ 2014; 38(4): 308-14.
[http://dx.doi.org/10.1152/advan.00080.2014] [PMID: 25434013]
[6]
Jia LL, Kang YM, Wang FX, et al. Exercise training attenuates hypertension and cardiac hypertrophy by modulating neurotransmitters and cytokines in hypothalamic paraventricular nucleus. PLoS One 2014; 9(1):e85481
[http://dx.doi.org/10.1371/journal.pone.0085481] [PMID: 24482680]
[7]
Lade C, Marins JCB, Lima L, Albuquerque M, Teixeira R, Reis J. Nível de atividade física habitual em portadores e não portadores de neuropatia diabética. RBAFS 2016; 21(4): 324-33.
[http://dx.doi.org/10.12820/rbafs.v.21n4p324-333]
[8]
Teixeira RB, Marins JCB, Amorim PRS, et al. Evaluating the effects of exercise on cognitive function in hypertensive and diabetic patients using the mental test and training system. World J Biol Psychiatry 2019; 20(3): 209-18.
[PMID: 28657472]
[9]
Antunes HKM, Santos-Galduroz RF, De Aquino Lemos V, et al. The influence of physical exercise and leisure activity on neuropsychological functioning in older adults. Age (Dordr) 2015; 37(4): 9815.
[http://dx.doi.org/10.1007/s11357-015-9815-8] [PMID: 26169946]
[10]
Hameed MA, Dasgupta I. Medication adherence and treatment-resistant hypertension: A review. Drugs Context 2019; 8212:560.
[http://dx.doi.org/10.7573/dic.212560] [PMID: 30774692]
[11]
Corder K, Ekelund U, Steele RM, Wareham NJ, Brage S. Assessment of physical activity in youth. J Appl Physiol 2008; 105(3): 977-87.
[http://dx.doi.org/10.1152/japplphysiol.00094.2008] [PMID: 18635884]
[12]
Tudor-Locke C, Hatano Y, Pangrazi RP, Kang M. Revisiting “how many steps are enough?”. Med Sci Sports Exerc 2008; 40(7): S537-43.
[http://dx.doi.org/10.1249/MSS.0b013e31817c7133] [PMID: 18562971]
[13]
Nitrini R, Lefèvre BH, Mathias SC, et al. Testes neuropsicológicos de aplicação simples para o diagnóstico de demência. Arq Neuropsiquiatr 1994; 52(4): 457-65.
[http://dx.doi.org/10.1590/S0004-282X1994000400001] [PMID: 7611936]
[14]
Valdez R. A simple model-based index of abdominal adiposity. J Clin Epidemiol 1991; 44(9): 955-6.
[http://dx.doi.org/10.1016/0895-4356(91)90059-I] [PMID: 1890438]
[15]
Ashwell M, Hsieh SD. Six reasons why the waist-to-height ratio is a rapid and effective global indicator for health risks of obesity and how its use could simplify the international public health message on obesity. Int J Food Sci Nutr 2005; 56(5): 303-7.
[http://dx.doi.org/10.1080/09637480500195066] [PMID: 16236591]
[16]
Bergman RN, Stefanovski D, Buchanan TA, et al. A better index of body adiposity. Obesity (Silver Spring) 2011; 19(5): 1083-9.
[http://dx.doi.org/10.1038/oby.2011.38] [PMID: 21372804]
[17]
Motamed N, Rabiee B, Hemasi GR, et al. Body roundness index and waist-to-height ratio are strongly associated with non-alcoholic fatty liver disease: A population-based study. Hepat Mon 2016; 16(9)e39575
[http://dx.doi.org/10.5812/hepatmon.39575] [PMID: 27822266]
[18]
World Health Organization. Physical status: The use and interpretation of anthropometry Report of a WHO Expert Committee. Geneva: World Health Organization 1995.
[19]
Marfell-Jones M, Olds T, Stewart AA. International standards foanthropometric assessment International Society for the Advancement of KinanthropometryISAK 2006.
[20]
Tyburski E, Sokołowski A, Chęć M, Pełka-Wysiecka J, Samochowiec A. Neuropsychological characteristics of verbal and non-verbal fluency in schizophrenia patients. Arch Psychiatr Nurs 2015; 29(1): 33-8.
[http://dx.doi.org/10.1016/j.apnu.2014.09.009] [PMID: 25634872]
[21]
Amieva H, Le Goff M, Millet X, et al. Prodromal Alzheimer’s disease: Successive emergence of the clinical symptoms. Ann Neurol 2008; 64(5): 492-8.
[PMID: 19067364]
[22]
Santini E, Huynh TN, Klann E. Mechanisms of translation control underlying long-lasting synaptic plasticity and the consolidation of long-term memory. Prog Mol Biol Transl Sci 2014; 122: 131-67.
[http://dx.doi.org/10.1016/B978-0-12-420170-5.00005-2] [PMID: 24484700]
[23]
Pitsikas N. The role of nitric oxide in the object recognition memory. Behav Brain Res 2015; 285: 200-7.
[http://dx.doi.org/10.1016/j.bbr.2014.06.008] [PMID: 24933185]
[24]
Terrera GM, Minett T, Brayne C, Matthews FE. Education associated with a delayed onset of terminal decline. Age Ageing 2014; 43(1): 26-31.
[http://dx.doi.org/10.1093/ageing/aft150] [PMID: 24136340]
[25]
De Silva TM, Faraci FM. Microvascular dysfunction and cognitive impairment. Cell Mol Neurobiol 2016; 36(2): 241-58.
[http://dx.doi.org/10.1007/s10571-015-0308-1] [PMID: 26988697]
[26]
De Felice FG, Lourenco MV, Ferreira ST. How does brain insulin resistance develop in Alzheimer’s disease? Alzheimers Dement 2014; 10(1): S26-32.
[PMID: 24529521]
[27]
Gottesman RF, Schneider AL, Albert M, et al. Midlife hypertension and 20-year cognitive change: the atherosclerosis risk in communities neurocognitive study. JAMA Neurol 2014; 71(10): 1218-27.
[PMID: 25090106]
[28]
Muela HC, Costa-hong VA, Machado MF, et al. Hypertension Severity is Associated With Impaired Cognitive Performance. Circulation 2015; 132(3):A17612.
[29]
Willette AA, Bendlin BB, Starks EJ, et al. Association of insulin resistance with cerebral glucose uptake in late middle-aged adults at risk for Alzheimer disease. JAMA Neurol 2015; 72(9): 1013-20.
[http://dx.doi.org/10.1001/jamaneurol.2015.0613] [PMID: 26214150]
[30]
Neergaard JS, Dragsbæk K, Christiansen C, et al. Metabolic syndrome, insulin resistance, and cognitive dysfunction: Does your metabolic profile affect your brain? Diabetes 2017; 66(7): 1957-63.
[http://dx.doi.org/10.2337/db16-1444] [PMID: 28389469]
[31]
Kim M, Park JM. Factors affecting cognitive function according to gender in community-dwelling elderly individuals. Epidemiol Health 2017; 39,e2017054.
[http://dx.doi.org/10.4178/epih.e2017054] [PMID: 29141399]
[32]
Reas ET, Laughlin GA, Bergstrom J, et al. Efeitos do sexo e da educação na mudança cognitiva em um período de 27 anos em idosos: o estudo de Rancho Bernardo. Am J Geriatr Psychiatry 2017; 25(8): 889-99.
[http://dx.doi.org/10.1016/j.jagp.2017.03.008] [PMID: 28433548]
[33]
Maldonado-Ruiz R, Montalvo-Martínez L, Fuentes-Mera L, Camacho A. Microglia activation due to obesity programs metabolic failure leading to type two diabetes. Nutr Diabetes 2017; 7(3): e254.
[http://dx.doi.org/10.1038/nutd.2017.10] [PMID: 28319103]
[34]
Bielemann RM, Silva BGCD, Coll CdeV, Xavier MO, Silva SGD. Burden of physical inactivity and hospitalization costs due to chronic diseases. Rev Saude Publica 2015; 49: 75.
[http://dx.doi.org/10.1590/S0034-8910.2015049005650] [PMID: 26487291]
[35]
Xu X, Parker D, Shi Z, Byles J, Hall J, Hickman L. Dietary pattern, hypertension and cognitive function in an older population: 10-year longitudinal survey. Front Public Health 2018; 6: 201.
[http://dx.doi.org/10.3389/fpubh.2018.00201] [PMID: 30079333]
[36]
de Rezende LFM, Rey-López JP, Matsudo VKR, do Carmo Luiz O. Sedentary behavior and health outcomes among older adults: A systematic review. BMC Public Health 2014; 14(1): 333.
[http://dx.doi.org/10.1186/1471-2458-14-333] [PMID: 24712381]
[37]
Rawlings AM, Sharrett AR, Schneider AL, et al. Diabetes in midlife and cognitive change over 20 years: a cohort study. Ann Intern Med 2014; 161(11): 785-93.
[PMID: 25437406]

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