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Current Pharmaceutical Design

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ISSN (Print): 1381-6128
ISSN (Online): 1873-4286

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Review Article

Marine-derived Polyaromatic Butenolides - Isolation, Synthesis and Biological Evaluations

Author(s): Joe Bracegirdle and Robert A. Keyzers*

Volume 26, Issue 35, 2020

Page: [4351 - 4361] Pages: 11

DOI: 10.2174/1381612826666200518110617

Price: $65

Abstract

Marine invertebrates, especially tunicates, are a lucrative resource for the discovery of new lead compounds for the development of clinically utilized drugs. This review describes the isolation, synthesis and biological activities of several classes of marine-derived butenolide natural products, namely rubrolides and related cadiolides and prunolides. All relevant studies pertaining to these compounds up to the end of 2019 are included.

Keywords: Marine natural products, rubrolides, cadiolides, prunolides, antibiotics, synthesis.

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