Login Register Cart 0
Generic placeholder image

Current Medical Imaging

Editor-in-Chief

ISSN (Print): 1573-4056
ISSN (Online): 1875-6603

Back
Journal Home About Journal Editorial Board Journal Insight Current Issue Volumes/Issues
Subscribe
Research Article

Multiparametric MRI Evaluation of Developmental Venous Anomalies in the Brain: Association with Signal Changes on FLAIR in Patients with Multiple Sclerosis

Author(s): Ergin Sagtas, Serkan Guneyli*, Dincer Aydin Akyilmaz, Huseyin Gokhan Yavas, Pinar Cakmak and Furkan Ufuk

Volume 16, Issue 7, 2020

Page: [928 - 935] Pages: 8

DOI: 10.2174/1573405616666200516172759

Price: $65

Abstract

Background: Developmental venous anomalies (DVAs) can be determined on magnetic resonance imaging (MRI), and they may be associated with multiple sclerosis (MS) lesions.

Purpose: The objective was to evaluate the MRI findings of DVAs in the brain, to compare the prevalence of them between MS patients and control subjects, and to investigate the correlation of DVA-associated fluid-attenuated inversion recovery (FLAIR) hyperintensities and MRI-derived parameters between MS patients and control subjects having DVA.

Methods: Total 160 patients with a mean age of 45 ± 16 years who underwent multiparametric MRI including susceptibility-weighted imaging (SWI), diffusion-weighted imaging, 3D FLAIR, and contrast-enhanced imaging were included in this retrospective study. First, the presence of DVA was compared between the MS and control groups using the Chi-square test. Then, among the subjects having DVA, age, gender, and MRI-derived parameters such as the signal increase of DVA on FLAIR, location, and drainage of DVA were compared between the MS and control groups using Chi-square test.

Results: The presence of DVA did not differ between the MS and control groups (P = 0.828). Signal increase around DVA on FLAIR (P = 0.03) and the age of less than 45 years demonstrated a significant correlation with MS group (P = 0.022).

Conclusion: In our study, DVAs were effectively detected using SWI and 3D contrast-enhanced T1-weighted imaging on MRI. The signal increase of DVA was better revealed on 3D FLAIR on MRI, and it was the only significant MRI-derived parameter in patients with MS.

Keywords: Developmental venous anomaly, fluid-attenuated inversion recovery, magnetic resonance imaging, multiple sclerosis, susceptibility-weighted imaging, FLAIR.

Graphical Abstract

[1]
Abe, T.; Singer, R.J.; Marks, M.P.; Norbash, A.M.; Crowley, R.S.; Steinberg, G.K. Coexistence of occult vascular malformations and developmental venous anomalies in the central nervous system: MR evaluation. AJNR Am. J. Neuroradiol., 1998, 19(1), 51-57.
[PMID: 9432157]
[2]
Huber, G.; Henkes, H.; Hermes, M.; Felber, S.; Terstegge, K.; Piepgras, U. Regional association of developmental venous anomalies with angiographically occult vascular malformations. Eur. Radiol., 1996, 6(1), 30-37.
[http://dx.doi.org/10.1007/BF00619949] [PMID: 8797947]
[3]
Wilms, G.; Bleus, E.; Demaerel, P.; Marchal, G.; Plets, C.; Goffin, J.; Baert, A.L. Simultaneous occurrence of developmental venous anomalies and cavernous angiomas. AJNR Am. J. Neuroradiol., 1994, 15(7), 1247-1254.
[PMID: 7976933]
[4]
Okudera, T.; Huang, Y.P.; Fukusumi, A.; Nakamura, Y.; Hatazawa, J.; Uemura, K. Micro-angiographical studies of the medullary venous system of the cerebral hemisphere. Neuropathology, 1999, 19(1), 93-111.
[http://dx.doi.org/10.1046/j.1440-1789.1999.00215.x] [PMID: 19519653]
[5]
Lasjaunias, P.; Burrows, P.; Planet, C. Developmental venous anomalies (DVA): the so-called venous angioma. Neurosurg. Rev., 1986, 9(3), 233-242.
[http://dx.doi.org/10.1007/BF01743138] [PMID: 3550523]
[6]
Santucci, G.M.; Leach, J.L.; Ying, J.; Leach, S.D.; Tomsick, T.A. Brain parenchymal signal abnormalities associated with developmental venous anomalies: detailed MR imaging assessment. AJNR Am. J. Neuroradiol., 2008, 29(7), 1317-1323.
[http://dx.doi.org/10.3174/ajnr.A1090] [PMID: 18417603]
[7]
Reichenbach, J.R.; Jonetz-Mentzel, L.; Fitzek, C.; Haacke, E.M.; Kido, D.K.; Lee, B.C.; Kaiser, W.A. High-resolution blood oxygen-level dependent MR venography (HRBV): a new technique. Neuroradiology, 2001, 43(5), 364-369.
[http://dx.doi.org/10.1007/s002340000503] [PMID: 11396739]
[8]
Takasugi, M.; Fujii, S.; Shinohara, Y.; Kaminou, T.; Watanabe, T.; Ogawa, T. Parenchymal hypointense foci associated with developmental venous anomalies: evaluation by phase-sensitive MR Imaging at 3T. AJNR Am. J. Neuroradiol., 2013, 34(10), 1940-1944.
[http://dx.doi.org/10.3174/ajnr.A3495] [PMID: 23598832]
[9]
Rogers, D.M.; Peckham, M.E.; Shah, L.M.; Wiggins, R.H., III Association of Developmental Venous Anomalies with Demyelinating Lesions in Patients with Multiple Sclerosis. AJNR Am. J. Neuroradiol., 2018, 39(1), 97-101.
[http://dx.doi.org/10.3174/ajnr.A5374] [PMID: 28912286]
[10]
Umino, M.; Maeda, M.; Matsushima, N.; Matsuura, K.; Yamada, T.; Sakuma, H. High-signal-intensity abnormalities evaluated by 3D fluid-attenuated inversion recovery imaging within the drainage territory of developmental venous anomalies identified by susceptibility-weighted imaging at 3 T. Jpn. J. Radiol., 2014, 32(7), 397-404.
[http://dx.doi.org/10.1007/s11604-014-0322-0] [PMID: 24793590]
[11]
San Millán Ruíz, D.; Delavelle, J.; Yilmaz, H.; Gailloud, P.; Piovan, E.; Bertramello, A.; Pizzini, F.; Rüfenacht, D.A. Parenchymal abnormalities associated with developmental venous anomalies. Neuroradiology, 2007, 49(12), 987-995.
[http://dx.doi.org/10.1007/s00234-007-0279-0] [PMID: 17703296]
[12]
Linscott, L.L.; Leach, J.L.; Zhang, B.; Jones, B.V. Brain parenchymal signal abnormalities associated with developmental venous anomalies in children and young adults. AJNR Am. J. Neuroradiol., 2014, 35(8), 1600-1607.
[http://dx.doi.org/10.3174/ajnr.A3960] [PMID: 24831595]
[13]
Jung, H.N.; Kim, S.T.; Cha, J.; Kim, H.J.; Byun, H.S.; Jeon, P.; Kim, K.H.; Kim, B.J.; Kim, H.J. Diffusion and perfusion MRI findings of the signal-intensity abnormalities of brain associated with developmental venous anomaly. AJNR Am. J. Neuroradiol., 2014, 35(8), 1539-1542.
[http://dx.doi.org/10.3174/ajnr.A3900] [PMID: 24651815]
[14]
Rogers, D.M.; Shah, L.M.; Wiggins, R.H., III The Central Vein: FLAIR Signal Abnormalities Associated with Developmental Venous Anomalies in Patients with Multiple Sclerosis. AJNR Am. J. Neuroradiol., 2018, 39(11), 2007-2013.
[http://dx.doi.org/10.3174/ajnr.A5819] [PMID: 30337437]
[15]
Iv, M.; Fischbein, N.J.; Zaharchuk, G. Association of developmental venous anomalies with perfusion abnormalities on arterial spin labeling and bolus perfusion-weighted imaging. J. Neuroimaging, 2015, 25(2), 243-250.
[http://dx.doi.org/10.1111/jon.12119] [PMID: 24717021]
[16]
Camacho, D.L.; Smith, J.K.; Grimme, J.D.; Keyserling, H.F.; Castillo, M. Atypical MR imaging perfusion in developmental venous anomalies. AJNR Am. J. Neuroradiol., 2004, 25(9), 1549-1552.
[PMID: 15502136]
[17]
Sharma, A.; Zipfel, G.J.; Hildebolt, C.; Derdeyn, C.P. Hemodynamic effects of developmental venous anomalies with and without cavernous malformations. AJNR Am. J. Neuroradiol., 2013, 34(9), 1746-1751.
[http://dx.doi.org/10.3174/ajnr.A3516] [PMID: 23598827]
[18]
Hanson, E.H.; Roach, C.J.; Ringdahl, E.N.; Wynn, B.L.; DeChancie, S.M.; Mann, N.D.; Diamond, A.S.; Orrison, W.W., Jr Developmental venous anomalies: appearance on whole-brain CT digital subtraction angiography and CT perfusion. Neuroradiology, 2011, 53(5), 331-341.
[http://dx.doi.org/10.1007/s00234-010-0739-9] [PMID: 20652805]
[19]
Sasani, M.R.; Dehghan, A.R.; Ali Reza, N. The relationship of multiple sclerosis and cerebral developmental venous anomaly with an advantageous role in the multiple sclerosis diagnosis. Iran. J. Neurol., 2017, 16(4), 168-172.
[PMID: 29736221]
[20]
Thompson, A.J.; Banwell, B.L.; Barkhof, F.; Carroll, W.M.; Coetzee, T.; Comi, G.; Correale, J.; Fazekas, F.; Filippi, M.; Freedman, M.S.; Fujihara, K.; Galetta, S.L.; Hartung, H.P.; Kappos, L.; Lublin, F.D.; Marrie, R.A.; Miller, A.E.; Miller, D.H.; Montalban, X.; Mowry, E.M.; Sorensen, P.S.; Tintoré, M.; Traboulsee, A.L.; Trojano, M.; Uitdehaag, B.M.J.; Vukusic, S.; Waubant, E.; Weinshenker, B.G.; Reingold, S.C.; Cohen, J.A. Diagnosis of multiple sclerosis: 2017 revisions of the McDonald criteria. Lancet Neurol., 2018, 17(2), 162-173.
[http://dx.doi.org/10.1016/S1474-4422(17)30470-2] [PMID: 29275977]
[21]
Jones, B.V.; Linscott, L.; Koberlein, G.; Hummel, T.R.; Leach, J.L. Increased Prevalence of Developmental Venous Anomalies in Children with Intracranial Neoplasms. AJNR Am. J. Neuroradiol., 2015, 36(9), 1782-1785.
[http://dx.doi.org/10.3174/ajnr.A4352] [PMID: 26021620]
[22]
Truwit, C.L. Venous angioma of the brain: history, significance, and imaging findings. AJR Am. J. Roentgenol., 1992, 159(6), 1299-1307.
[http://dx.doi.org/10.2214/ajr.159.6.1442406] [PMID: 1442406]
[23]
Sarwar, M.; McCormick, W.F. Intracerebral venous angioma. Case report and review. Arch. Neurol., 1978, 35(5), 323-325.
[http://dx.doi.org/10.1001/archneur.1978.00500290069012] [PMID: 646686]
[24]
Ma, M.; Chen, J.Y.; Plowey, E.D.; Fischbein, N.; Iv, M. Tumefactive demyelination associated with developmental venous anomaly: Report of two cases. Clin. Imaging, 2017, 43(3), 194-198.
[http://dx.doi.org/10.1016/j.clinimag.2017.02.012] [PMID: 28364723]
[25]
Moody, D.M.; Brown, W.R.; Challa, V.R.; Anderson, R.L. Periventricular venous collagenosis: association with leukoaraiosis. Radiology, 1995, 194(2), 469-476.
[http://dx.doi.org/10.1148/radiology.194.2.7824728] [PMID: 7824728]
[26]
Keith, J.; Gao, F.Q.; Noor, R.; Kiss, A.; Balasubramaniam, G.; Au, K.; Rogaeva, E.; Masellis, M.; Black, S.E. Collagenosis of the deep medullary veins: an underrecognized pathologic correlate of white matter hyperintensities and periventricular infarction? J. Neuropathol. Exp. Neurol., 2017, 76(4), 299-312.
[http://dx.doi.org/10.1093/jnen/nlx009] [PMID: 28431180]
[27]
Brown, W.R.; Moody, D.M.; Challa, V.R.; Thore, C.R.; Anstrom, J.A. Venous collagenosis and arteriolar tortuosity in leukoaraiosis. J. Neurol. Sci., 2002, 203-204(11), 159-163.
[http://dx.doi.org/10.1016/S0022-510X(02)00283-6] [PMID: 12417376]
[28]
Sati, P.; Oh, J.; Constable, R.T.; Evangelou, N.; Guttmann, C.R.; Henry, R.G.; Klawiter, E.C.; Mainero, C.; Massacesi, L.; McFarland, H.; Nelson, F.; Ontaneda, D.; Rauscher, A.; Rooney, W.D.; Samaraweera, A.P.; Shinohara, R.T.; Sobel, R.A.; Solomon, A.J.; Treaba, C.A.; Wuerfel, J.; Zivadinov, R.; Sicotte, N.L.; Pelletier, D.; Reich, D.S. NAIMS Cooperative. The central vein sign and its clinical evaluation for the diagnosis of multiple sclerosis: a consensus statement from the North American Imaging in Multiple Sclerosis Cooperative. Nat. Rev. Neurol., 2016, 12(12), 714-722.
[http://dx.doi.org/10.1038/nrneurol.2016.166] [PMID: 27834394]
[29]
Samaraweera, A.P.; Clarke, M.A.; Whitehead, A.; Falah, Y.; Driver, I.D.; Dineen, R.A.; Morgan, P.S.; Evangelou, N. The central vein sign in multiple sclerosis lesions is present irrespective of the T2* sequence at 3 T. J. Neuroimaging, 2017, 27(1), 114-121.
[http://dx.doi.org/10.1111/jon.12367] [PMID: 27300318]
[30]
Gaitán, M.I.; Sati, P.; Inati, S.J.; Reich, D.S. Initial investigation of the blood-brain barrier in MS lesions at 7 tesla. Mult. Scler., 2013, 19(8), 1068-1073.
[http://dx.doi.org/10.1177/1352458512471093] [PMID: 23246799]
[31]
Minagar, A.; Alexander, J.S. Blood-brain barrier disruption in multiple sclerosis. Mult. Scler., 2003, 9(6), 540-549.
[http://dx.doi.org/10.1191/1352458503ms965oa] [PMID: 14664465]
[32]
Matthews, P.M.; Roncaroli, F.; Waldman, A.; Sormani, M.P.; De Stefano, N.; Giovannoni, G.; Reynolds, R. A practical review of the neuropathology and neuroimaging of multiple sclerosis. Pract. Neurol., 2016, 16(4), 279-287.
[http://dx.doi.org/10.1136/practneurol-2016-001381] [PMID: 27009310]
[33]
Zamboni, P.; Galeotti, R.; Menegatti, E.; Malagoni, A.M.; Tacconi, G.; Dall’Ara, S.; Bartolomei, I.; Salvi, F. Chronic cerebrospinal venous insufficiency in patients with multiple sclerosis. J. Neurol. Neurosurg. Psychiatry, 2009, 80(4), 392-399.
[http://dx.doi.org/10.1136/jnnp.2008.157164] [PMID: 19060024]
[34]
Zamboni, P.; Menegatti, E.; Galeotti, R.; Malagoni, A.M.; Tacconi, G.; Dall’Ara, S.; Bartolomei, I.; Salvi, F. The value of cerebral Doppler venous haemodynamics in the assessment of multiple sclerosis. J. Neurol. Sci., 2009, 282(1-2), 21-27.
[http://dx.doi.org/10.1016/j.jns.2008.11.027] [PMID: 19144359]
[35]
Krogias, C.; Schröder, A.; Wiendl, H.; Hohlfeld, R.; Gold, R. [“Chronic cerebrospinal venous insufficiency” and multiple sclerosis: critical analysis and first observation in an unselected cohort of MS patients]. Nervenarzt, 2010, 81(6), 740-746.
[http://dx.doi.org/10.1007/s00115-010-2972-1] [PMID: 20386873]
[36]
Traboulsee, A.L.; Knox, K.B.; Machan, L.; Zhao, Y.; Yee, I.; Rauscher, A.; Klass, D.; Szkup, P.; Otani, R.; Kopriva, D.; Lala, S.; Li, D.K.; Sadovnick, D. Prevalence of extracranial venous narrowing on catheter venography in people with multiple sclerosis, their siblings, and unrelated healthy controls: a blinded, case-control study. Lancet, 2014, 383(9912), 138-145.
[http://dx.doi.org/10.1016/S0140-6736(13)61747-X] [PMID: 24119384]
[37]
Doepp, F.; Paul, F.; Valdueza, J.M.; Schmierer, K.; Schreiber, S.J. No cerebrocervical venous congestion in patients with multiple sclerosis. Ann. Neurol., 2010, 68(2), 173-183.
[PMID: 20695010]

Rights & Permissions Print Cite
Article Metrics
7
© 2024 Bentham Science Publishers | Privacy Policy