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General Review Article

利用ADAR进行人工RNA编辑以进行基因治疗

卷 20, 期 1, 2020

页: [44 - 54] 页: 11

弟呕挨: 10.2174/1566523220666200516170137

价格: $65

摘要

编辑突变基因是一种潜在的治疗遗传病的方法。G-to-A突变在哺乳动物中很常见，可以通过腺苷到肌苷(a -to-i)编辑来治疗，这是一种置换型RNA编辑。A-to-I编辑的分子机制涉及腺苷水解脱氨为肌苷碱;这种反应是由RNA特异性脱氨酶，腺苷脱氨酶作用于RNA (ADARs)，家族蛋白介导的。在此，我们回顾了有关应用ADAR恢复遗传密码的最新发现，以及在ADAR人工RNA编辑过程中涉及的不同方法。我们还讨论了各种ADARs异构体的比较研究。因此，我们将尝试提供人工RNA编辑和ADAR的作用的详细概述，重点是酶位点指导a -to- i编辑。

关键词: RNA编辑

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图形摘要

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