摘要
树突状细胞(DC)是连接先天和适应性免疫反应的最强大的抗原呈递细胞。根据于上下文,DC启动免疫反应或促进免疫耐受。它们的表型和功能的任何紊乱都可能引发炎性或自身免疫性疾病。因此,失调的DCs是旨在降低其免疫原性并增强其耐受性的新疗法开发的最有吸引力的药理学靶标。姜黄素是香料姜黄的多酚植物化学成分,具有广泛的药理活性。它以多种方式充当DC的调制器,并将其转换为耐受DC。致耐受性DC具有调节健康和疾病中免疫反应的抗炎和免疫调节活性。姜黄素通过阻断成熟标志物,细胞因子和趋化因子的表达,并破坏DC的抗原呈递机制,使DC对免疫刺激剂无反应或反应低下。它也减少了共刺激分子和粘附分子在DC上的表达,并阻止它们迁移和抗原呈递,但增强了它们的内吞能力。因此,姜黄素会引起DC诱导的调节性T细胞,并抑制CD4 + T辅助物1(Th1),Th2和Th17极化。转录因子(如NF-κB,AP-1,MAPKs(p38,JNK,ERK)和其他细胞内信号分子(如JAK / STAT / SOCS)的抑制为大多数这些观察提供了合理的解释。在这篇综述中,我们总结了姜黄素对DC的表型和功能的潜在影响,DC是协调,刺激和调节免疫反应的关键因素。
关键词: 姜黄素,免疫调节剂,树突状细胞,自身免疫,炎症,硬膜外植物化学物质,树突状细胞。
[http://dx.doi.org/10.4049/jimmunol.1701024] [PMID: 29311386]
[http://dx.doi.org/10.1038/cr.2016.157] [PMID: 28025976]
[http://dx.doi.org/10.1007/s12026-017-8931-1] [PMID: 28660480]
[http://dx.doi.org/10.1158/1078-0432.ccr-15-1399] [PMID: 27084743]
[PMID: 29119057]
[http://dx.doi.org/10.1016/j.biopha.2016.05.037] [PMID: 27470399]
[http://dx.doi.org/10.1111/j.1440-1681.2011.05648.x] [PMID: 22118895]
[http://dx.doi.org/10.1016/j.tips.2008.11.002] [PMID: 19110321]
[http://dx.doi.org/10.1016/j.biopha.2016.11.050] [PMID: 27894665]
[http://dx.doi.org/10.1002/jcb.28843] [PMID: 31074052]
[http://dx.doi.org/10.1055/s-0043-100019] [PMID: 28158893]
[http://dx.doi.org/10.1002/jcp.25778] [PMID: 28059453]
[http://dx.doi.org/10.1016/j.phymed.2009.05.020] [PMID: 19577457]
[http://dx.doi.org/10.2174/1381612822666160527113501] [PMID: 27229723]
[http://dx.doi.org/10.1080/10408398.2017.1358139] [PMID: 28799796]
[http://dx.doi.org/10.1016/j.phrs.2016.12.037] [PMID: 28042086]
[http://dx.doi.org/10.1016/j.fertnstert.2010.07.1071] [PMID: 20797714]
[http://dx.doi.org/10.1016/j.intimp.2010.08.014] [PMID: 20828642]
[http://dx.doi.org/10.1007/978-0-387-46401-5_10] [PMID: 17569214]
[http://dx.doi.org/10.2174/138945011794815356] [PMID: 20955148]
[http://dx.doi.org/10.1016/j.jnutbio.2018.12.005] [PMID: 30660832]
[http://dx.doi.org/10.1016/j.autrev.2019.05.012] [PMID: 31059845]
[PMID: 2405475]
[http://dx.doi.org/10.1016/j.immuni.2011.09.007] [PMID: 21943488]
[http://dx.doi.org/10.1016/j.critrevonc.2018.05.009] [PMID: 29958625]
[http://dx.doi.org/10.1002/jcp.26429] [PMID: 29319160]
[http://dx.doi.org/10.1016/j.autrev.2017.11.016] [PMID: 29180127]
[http://dx.doi.org/10.1146/annurev-immunol-020711-074950] [PMID: 23516985]
[http://dx.doi.org/10.1007/s00018-015-2005-0] [PMID: 26243730]
[http://dx.doi.org/10.1126/science.1178331] [PMID: 20133564]
[http://dx.doi.org/10.1016/j.jaut.2015.07.011] [PMID: 26255250]
[http://dx.doi.org/10.1007/s00281-016-0587-8] [PMID: 27646959]
[http://dx.doi.org/10.1182/blood.V95.10.3162] [PMID: 10807783]
[http://dx.doi.org/10.1002/eji.1830251016] [PMID: 7589077]
[http://dx.doi.org/10.1002/jlb.66.6.909] [PMID: 10614771]
[http://dx.doi.org/10.1016/S0301-472X(00)00143-0] [PMID: 10812248]
[http://dx.doi.org/10.1111/imm.12776] [PMID: 28617989]
[http://dx.doi.org/10.1007/978-3-540-71029-5_12] [PMID: 19031030]
[http://dx.doi.org/10.1021/pr200724e] [PMID: 22103328]
[http://dx.doi.org/10.1530/eje.0.1450351] [PMID: 11517017]
[http://dx.doi.org/10.1016/j.jsbmb.2012.10.009] [PMID: 23098690]
[http://dx.doi.org/10.4049/jimmunol.167.4.1945] [PMID: 11489974]
[http://dx.doi.org/10.4049/jimmunol.165.5.2374] [PMID: 10946260]
[http://dx.doi.org/10.1046/j.1365-2249.2003.02269.x] [PMID: 12974756]
[http://dx.doi.org/10.4049/jimmunol.178.11.7018] [PMID: 17513751]
[http://dx.doi.org/10.1016/j.trim.2007.10.007] [PMID: 18158116]
[http://dx.doi.org/10.1182/blood-2002-11-3370] [PMID: 12531798]
[http://dx.doi.org/10.4049/jimmunol.166.12.7053] [PMID: 11390449]
[http://dx.doi.org/10.1016/j.intimp.2006.07.008] [PMID: 17219690]
[http://dx.doi.org/10.1046/j.1365-2567.2000.00065.x] [PMID: 11012753]
[http://dx.doi.org/10.3109/09687688.2010.525756] [PMID: 21231793]
[PMID: 10072497]
[http://dx.doi.org/10.1046/j.0009-9104.2002.01977.x] [PMID: 12390312]
[http://dx.doi.org/10.1016/j.cellimm.2012.05.011] [PMID: 22698927]
[http://dx.doi.org/10.1016/j.cellimm.2008.04.016] [PMID: 18522857]
[http://dx.doi.org/10.1016/j.jep.2015.05.050] [PMID: 26068430]
[http://dx.doi.org/10.1016/j.jmau.2016.01.001] [PMID: 30023210]
[http://dx.doi.org/10.2217/imt.14.77] [PMID: 25428644]
[http://dx.doi.org/10.1111/j.1365-2249.2010.04232.x] [PMID: 21070208]
[http://dx.doi.org/10.4049/jimmunol.174.12.8116] [PMID: 15944320]
[http://dx.doi.org/10.1016/j.bbrc.2008.07.051] [PMID: 18639521]
[http://dx.doi.org/10.1055/s-0028-1088367] [PMID: 19034830]
[http://dx.doi.org/10.1016/S0006-2952(97)00557-1] [PMID: 9586949]
[http://dx.doi.org/10.1093/carcin/bgm123] [PMID: 17522064]
[http://dx.doi.org/10.1038/sj.onc.1204083] [PMID: 11426644]
[http://dx.doi.org/10.1096/fasebj.9.9.7601337] [PMID: 7601337]
[http://dx.doi.org/10.1074/jbc.270.42.24995] [PMID: 7559628]
[http://dx.doi.org/10.4049/jimmunol.166.6.3837] [PMID: 11238627]
[http://dx.doi.org/10.1046/j.1365-2567.2002.01401.x] [PMID: 11972630]
[http://dx.doi.org/10.1182/blood-2002-05-1320] [PMID: 12393461]
[http://dx.doi.org/10.1016/j.immuni.2012.03.014] [PMID: 22520847]
[http://dx.doi.org/10.4049/jimmunol.0903991] [PMID: 20483746]
[http://dx.doi.org/10.1007/s10787-019-00607-3 ] [PMID: 31140036]
[http://dx.doi.org/10.3389/fphar.2016.00455] [PMID: 27932984]
[http://dx.doi.org/10.1182/blood-2004-08-3228] [PMID: 15855273]
[http://dx.doi.org/10.1038/nri2460] [PMID: 19096390]
[PMID: 9916729]
[http://dx.doi.org/10.1164/rccm.200209-1113OC] [PMID: 12574077]
[http://dx.doi.org/10.1172/JCI200523273] [PMID: 15761492]
[http://dx.doi.org/10.1073/pnas.1316447111] [PMID: 24550510]
[http://dx.doi.org/10.1136/gut.2004.048298] [PMID: 16099792]
[http://dx.doi.org/10.1016/j.jneuroim.2004.09.004] [PMID: 15589058]
[http://dx.doi.org/10.4049/jimmunol.181.11.7480] [PMID: 19017937]
[http://dx.doi.org/10.3892/mmr.2013.1695] [PMID: 24065177]
[http://dx.doi.org/10.1002/jcp.21835] [PMID: 19475568]
[http://dx.doi.org/10.3892/mmr.2011.538] [PMID: 21785824]
[http://dx.doi.org/10.1074/jbc.M207309200] [PMID: 12473670]
[http://dx.doi.org/10.1016/j.it.2013.07.006] [PMID: 23973621]
[http://dx.doi.org/10.1016/j.cyto.2014.09.011] [PMID: 25458968]
[http://dx.doi.org/10.1016/j.imlet.2018.02.001] [PMID: 29427742]
[http://dx.doi.org/10.1002/eji.200939052] [PMID: 19839007]
[http://dx.doi.org/10.1016/j.jaci.2007.08.026] [PMID: 17935769]
[http://dx.doi.org/10.1111/j.1365-2567.2009.03205.x] [PMID: 20002210]
[http://dx.doi.org/10.1080/02770903.2016.1218018] [PMID: 27715343]
[http://dx.doi.org/10.1016/j.febslet.2007.02.073] [PMID: 17367785]
[http://dx.doi.org/10.3389/fimmu.2017.01360] [PMID: 29163470]
[http://dx.doi.org/10.1038/nri1457] [PMID: 15459668]
[http://dx.doi.org/10.1038/s41568-019-0106-z] [PMID: 30696923]
[http://dx.doi.org/10.1016/j.intimp.2010.04.006] [PMID: 20399909]
[http://dx.doi.org/10.1074/jbc.M807328200] [PMID: 19075017]
[http://dx.doi.org/10.1093/intimm/dxr121] [PMID: 22378503]
[PMID: 17273796]
[http://dx.doi.org/10.1055/s-2007-990278] [PMID: 18213547]
[http://dx.doi.org/10.1155/2019/5481725] [PMID: 31210749]
[http://dx.doi.org/10.2337/db11-0275] [PMID: 21885868]
[http://dx.doi.org/10.1097/MIB.0b013e3182a69dca] [PMID: 23974993]
[http://dx.doi.org/10.1002/path.4277] [PMID: 24122796]
[http://dx.doi.org/10.1016/j.colsurfb.2016.03.038] [PMID: 27022873]
[http://dx.doi.org/10.2174/138161209788489177] [PMID: 19519446]
[http://dx.doi.org/10.1016/j.drudis.2016.03.007] [PMID: 26995272]
[http://dx.doi.org/10.1039/c2fo30097d] [PMID: 22833299]
[http://dx.doi.org/10.3390/molecules191221127] [PMID: 25521115]
[http://dx.doi.org/10.1152/ajpgi.90365.2008] [PMID: 18818316]
[http://dx.doi.org/10.3748/wjg.v22.i23.5374] [PMID: 27340353]