摘要
三阴性乳腺癌(TNBC)是最具侵袭性和最普遍的乳腺癌亚型。化疗药物用于治疗TNBC存在化疗耐药性、剂量限制毒副作用和脱靶副作用。因此，传统的化疗药物无法阻止肿瘤的生长、转移，导致治疗失败。各种新的靶点如BCSCs表面标记物(CD44、CD133、ALDH1)、信号通路(IL-6/JAK/STAT3、notch)、促凋亡和抗凋亡蛋白(Bcl-2、Bcl-xL、DR4、DR5)、缺氧因子(HIF-1 - 3、HIF-2 - 3)和药物外排转运体(ABCC1、ABCG2、ABCB1)已被开发用于治疗TNBC。此外，为了提高传统化疗药物的疗效和安全性，研究人员已经尝试使用基于纳米载体的药物给药，专门为TNBC提供抗癌药物。在这篇综述中，我们着重介绍了导致三氧化二氮耐药性的各种因素、三氧化二氮的新分子靶点以及利用纳米给药系统实现位点特异性给药以提高疗效和减少脱靶副作用。
关键词: 三阴性乳腺癌，转移，化疗耐药性，纳米载体，化疗耐药性，药物治疗。
图形摘要
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