Review Article

生化标志物在造影剂诱导急性肾损伤预测中的作用

卷 28, 期 6, 2021

发表于: 01 May, 2020

页: [1234 - 1250] 页: 17

弟呕挨: 10.2174/0929867327666200502015749

价格: $65

摘要

多年来,临床医生一直在寻找“肾肌钙蛋白”——一种评估急性肾损伤(AKI)风险的简单诊断工具。近来,造影剂相关手术(造影剂计算机断层扫描(CT),经皮冠状动脉介入(PCI)和血管造影剂)的增多导致造影剂引起的急性肾损伤(CI-AKI)的增加。CIAKI仍然是总体死亡率、住院时间延长和增加治疗总费用的一个重要原因。肾功能不全的后果影响生活质量,并可能导致残疾。目前国内外对CI-AKI的预测研究较多,但还没有敏感可靠的方法。肾损伤分子1 (KIM-1)和中性粒细胞明胶酶脂蛋白(NGAL)被认为是肾特异性分子。在实施与对比相关的程序之前,这些物质的高浓度被建议用于评估肾脏对CI-AKI的易感性,它们似乎具有心血管事件和总体死亡率的预测潜力。根据其他作者,常规测定已知的炎症因子(如CRP, WBC和中性粒细胞计数)可能有助于预测CIAKI。然而,临床试验的结果提供了截然不同的结果。造影剂肾病的病理机制尚不清楚。由于其流行,急性肾损伤的风险评估仍然是一个严重的问题有待解决。本文回顾了病理生理学,并提出了促进造影剂诱导急性肾损伤预测的最佳标记物。

关键词: 造影剂诱导的急性肾损伤,造影剂CT,经皮冠状动脉成形术,肾损伤分子1 (KIM-1),中性粒细胞明胶酶脂蛋白(NGAL),经皮冠状动脉介入治疗(PCI)

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