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General Review Article

Recent Advances in Molecular Marker-Assisted Breeding for Quality Improvement of Traditional Chinese Medicine

Author(s): Zhenqiao Song and Xingfeng Li*

Volume 22, Issue 6, 2021

Published on: 30 April, 2020

Page: [867 - 875] Pages: 9

DOI: 10.2174/1389201021666200430121013

Price: $65

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Abstract

Background: The quality of Traditional Chinese Medicine (TCM), reflected by its bioactive compounds and associated contents, is directly linked to its clinical efficacy. Therefore, it is of great importance to improve the quality of TCM by increasing the bioactive compound content.

Methods: Mapping the active component content-associated QTLs in TCM and further markerassisted breeding has enabled us to rapidly and effectively cultivate new varieties with high bioactive compound contents, which has opened the door for genetic breeding studies on medicinal plants.

Results: In this paper, a strategy and technical molecular breeding method for TCM are discussed. The development of four methods and progress in functional marker development, as well as the applications of such markers in TCM, are reviewed.

Conclusion: The progress in, challenges of, and future of marker-assisted breeding for quality improvement of TCM are discussed, which provide valuable scientific references for future molecular breeding.

Keywords: MAS, traditional Chinese medicinal plant, bioactive compound content, QTLs, expressed sequence tag, GWAS.

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