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Review Article

炎症性肠病中的外泌体:到目前为止我们了解到了什么?

卷 21, 期 14, 2020

页: [1448 - 1455] 页: 8

弟呕挨: 10.2174/1389450121666200428102330

价格: $65

摘要

炎症性肠病是一种免疫介导的慢性炎症性疾病。虽然病因尚不清楚，但有明显的黏膜免疫反应失衡，部分是由遗传易感性和肠道微生物失调造成的。充分抑制炎症活动并维持这种抑制是目前治疗的主要目标。然而，糖皮质激素只适用于活动性疾病的治疗，而免疫抑制剂的作用主要局限于缓解的维持。生物制剂已经广泛应用，并为IBD患者提供了治疗益处。然而，只有部分病人能从中受益。因此，迫切需要开发治疗IBD的新物质。外泌体是最近发现的纳米大小的脂质囊泡。它们由所有活细胞分泌，然后分布在各种人体体液中。据报道，不同细胞内外泌体分泌的microRNAs和功能蛋白等成分参与了IBD的发病机制。因此，外泌体有潜力成为治疗IBD的有吸引力的颗粒，作为一种无细胞治疗方法，以及诊断和监测疾病状态的生物标志物。外泌体在IBD临床应用的实用性、安全性和理想效果有待进一步研究。

关键词: 外泌体，炎症性肠病，发病机制，游离细胞治疗，临床应用，microRNAs

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图形摘要

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