Generic placeholder image

Combinatorial Chemistry & High Throughput Screening

Editor-in-Chief

ISSN (Print): 1386-2073
ISSN (Online): 1875-5402

Editorial

Computational Models and Methods for Drug Target Prediction and Drug Repositioning

Author(s): Guohua Huang

Volume 23, Issue 4, 2020

Page: [270 - 273] Pages: 4

DOI: 10.2174/138620732304200409112209

[1]
Adams, C.P.; Brantner, V.V. Estimating the cost of new drug development: is it really 802 million dollars? Health Aff. (Millwood), 2006, 25(2), 420-428.
[http://dx.doi.org/10.1377/hlthaff.25.2.420] [PMID: 16522582]
[2]
Huang, G.; Li, J.; Zhao, C. Computational prediction and analysis of associations between small molecules and binding-associated S-nitrosylation sites. Molecules, 2018, 23(4), 954.
[http://dx.doi.org/10.3390/molecules23040954] [PMID: 29671802]
[3]
Gu, W.; Miller, S.; Chiu, C.Y. Clinical metagenomic next-generation sequencing for pathogen detection. Annu. Rev. Pathol., 2019, 14, 319-338.
[http://dx.doi.org/10.1146/annurev-pathmechdis-012418-012751] [PMID: 30355154]
[4]
Mardis, E.R. The impact of next-generation sequencing on cancer genomics: from discovery to clinic. Cold Spring Harb. Perspect. Med., 2019, 9(9), a036269
[http://dx.doi.org/10.1101/cshperspect.a036269] [PMID: 30397020]
[5]
Ameur, A.; Kloosterman, W.P.; Hestand, M.S. Single-molecule sequencing: towards clinical applications. Trends Biotechnol., 2019, 37(1), 72-85.
[http://dx.doi.org/10.1016/j.tibtech.2018.07.013] [PMID: 30115375]
[6]
Battich, N.; Beumer, J.; de Barbanson, B.; Krenning, L.; Baron, C.S.; Tanenbaum, M.E.; Clevers, H.; van Oudenaarden, A. Sequencing metabolically labeled transcripts in single cells reveals mRNA turnover strategies. Science, 2020, 367(6482), 1151-1156.
[http://dx.doi.org/10.1126/science.aax3072] [PMID: 32139547]
[7]
Grinnan, D.; Trankle, C.; Andruska, A.; Bloom, B.; Spiekerkoetter, E. Drug repositioning in pulmonary arterial hypertension: challenges and opportunities. Pulm. Circ., 2019, 9(1), 2045894019832226
[http://dx.doi.org/10.1177/2045894019832226] [PMID: 30729869]
[8]
Xuan, P.; Cao, Y.; Zhang, T.; Wang, X.; Pan, S.; Shen, T. Drug repositioning through integration of prior knowledge and projections of drugs and diseases. Bioinformatics, 2019, 35(20), 4108-4119.
[http://dx.doi.org/10.1093/bioinformatics/btz182] [PMID: 30865257]
[9]
Zeng, X.; Zhu, S.; Liu, X.; Zhou, Y.; Nussinov, R.; Cheng, F. deepDR: a network-based deep learning approach to in silico drug repositioning. Bioinformatics, 2019, 35(24), 5191-5198.
[http://dx.doi.org/10.1093/bioinformatics/btz418] [PMID: 31116390]
[10]
Turanli, B.; Altay, O.; Borén, J.; Turkez, H.; Nielsen, J.; Uhlen, M.; Arga, K.Y.; Mardinoglu, A. Systems biology based drug repositioning for development of cancer therapy. Semin. Cancer Biol., 2019. E-pub ahead of print
[http://dx.doi.org/10.1016/j.semcancer.2019.09.020] [PMID: 31568815]
[11]
Daryaee, F.; Tonge, P.J. Pharmacokinetic-pharmacodynamic models that incorporate drug-target binding kinetics. Curr. Opin. Chem. Biol., 2019, 50, 120-127.
[http://dx.doi.org/10.1016/j.cbpa.2019.03.008] [PMID: 31030171]
[12]
IJzerman, A.P.; Guo, D. Drug-target association kinetics in drug discovery. Trends Biochem. Sci., 2019, 44(10), 861-871.
[http://dx.doi.org/10.1016/j.tibs.2019.04.004] [PMID: 31101454]
[13]
Nguyen, P.A.; Born, D.A.; Deaton, A.M.; Nioi, P.; Ward, L.D. Phenotypes associated with genes encoding drug targets are predictive of clinical trial side effects. Nat. Commun., 2019, 10, 1-11.
[14]
Miranda, M.R.; Sayé, M.M. Chagas disease treatment: from new therapeutic targets to drug discovery and repositioning. Curr. Med. Chem., 2019, 26(36), 6517-6518.
[http://dx.doi.org/10.2174/092986732636191202125919] [PMID: 31849285]
[15]
Parisi, D.; Adasme, M.F.; Sveshnikova, A.; Moreau, Y.; Schroeder, M. Drug repositoning or target repositioning: a structural perspective of drug-target-indication relationship for available repurposed drugs. bioRxiv, 2019. [Pre-print article].
[http://dx.doi.org/10.1101/715094]
[16]
Che, J.; Chen, L.; Guo, Z-H.G.; Wang, S. Aorigele, Drug target group prediction with multiple drug networks. Comb. Chem. High Throughput Screen., 2020, 23(4), 274-285.
[http://dx.doi.org/10.2174/1386207322666190702103927] [PMID: 31267864]
[17]
Kuhn, M.; Szklarczyk, D.; Pletscher-Frankild, S.; Blicher, T.H.; von Mering, C.; Jensen, L.J.; Bork, P. STITCH 4: integration of protein-chemical interactions with user data. Nucleic Acids Res., 2014, 42(Database issue), D401-D407.
[http://dx.doi.org/10.1093/nar/gkt1207] [PMID: 24293645]
[18]
Cho, H.; Berger, B.; Peng, J. Compact integration of multi-network topology for functional analysis of genes. Cell Syst., 2016, 3, 540-548.
[http://dx.doi.org/10.1016/j.cels.2016.10.017]
[19]
Cortes, C.; Vapnik, V. Support-vector networks. Mach. Learn., 1995, 20, 273-297.
[http://dx.doi.org/10.1007/BF00994018]
[20]
Lee, S.; Lee, K.H.; Song, M.; Lee, D. Building the process-drug–side effect network to discover the relationship between biological processes and side effects. BMC Bioinformatics, 2011, 12, S2.
[http://dx.doi.org/10.1186/1471-2105-12-S2-S2]
[21]
Pauwels, E.; Stoven, V.; Yamanishi, Y. Predicting drug side-effect profiles: a chemical fragment-based approach. BMC Bioinformatics, 2011, 12, 169.
[http://dx.doi.org/10.1186/1471-2105-12-169] [PMID: 21586169]
[22]
Zhou, B.; Zhao, X.; Lu, J.; Sun, Z.; Liu, M.; Zhou, Y.; Liu, R.; Wang, Y. Relating substructures and side effects of drugs with chemical-chemical interactions. Comb. Chem. High Throughput Screen., 2020, 23(4), 285-294.
[http://dx.doi.org/10.2174/1386207322666190702102752] [PMID: 31267865]
[23]
Crişan, A.M. BădeliŢă, S.N.; Jardan, C.; Vasilache, E.D.; Dobrea, C.M.; Gheorghe, A.; Tălmaci, R.; Arion, C.V.; Bardaş, A.; Găman, A.M.; Coriu, D. The occurrence of chronic lymphocytic leukemia after chronic phase of chronic myeloid leukemia: case report and literature review. Rom. J. Morphol. Embryol., 2015, 56(3), 1145-1151.
[PMID: 26662151]
[24]
Nagao, T.; Takahashi, N.; Kameoka, Y.; Noguchi, S.; Shinohara, Y.; Ohyagi, H.; Kume, M.; Sawada, K. Dasatinib-responsive chronic lymphocytic leukemia in a patient treated for coexisting chronic myeloid leukemia. Intern. Med., 2013, 52(22), 2567-2571.
[http://dx.doi.org/10.2169/internalmedicine.52.0392] [PMID: 24240798]
[25]
Lu, J.; Zhang, Y-H.; Wang, S.; Bi, Y.; Huang, T.; Luo, X.; Cai, Y-D. Analysis of four types of leukemia using gene ontology term and kyoto encyclopedia of genes and genomes pathway enrichment scores. Comb. Chem. High Throughput Screen., 2020, 23(4), 295-303.
[http://dx.doi.org/10.2174/1386207322666181231151900] [PMID: 30599106]
[26]
Harris, M.A.; Clark, J.; Ireland, A.; Lomax, J.; Ashburner, M.; Foulger, R.; Eilbeck, K.; Lewis, S.; Marshall, B.; Mungall, C.; Richter, J.; Rubin, G.M.; Blake, J.A.; Bult, C.; Dolan, M.; Drabkin, H.; Eppig, J.T.; Hill, D.P.; Ni, L.; Ringwald, M.; Balakrishnan, R.; Cherry, J.M.; Christie, K.R.; Costanzo, M.C.; Dwight, S.S.; Engel, S.; Fisk, D.G.; Hirschman, J.E.; Hong, E.L.; Nash, R.S.; Sethuraman, A.; Theesfeld, C.L.; Botstein, D.; Dolinski, K.; Feierbach, B.; Berardini, T.; Mundodi, S.; Rhee, S.Y.; Apweiler, R.; Barrell, D.; Camon, E.; Dimmer, E.; Lee, V.; Chisholm, R.; Gaudet, P.; Kibbe, W.; Kishore, R.; Schwarz, E.M.; Sternberg, P.; Gwinn, M.; Hannick, L.; Wortman, J.; Berriman, M.; Wood, V.; de la Cruz, N.; Tonellato, P.; Jaiswal, P.; Seigfried, T.; White, R. The gene ontology (GO) database and informatics resource. Nucleic Acids Res., 2004, 32(Database issue), D258-D261.
[PMID: 14681407]
[27]
Kanehisa, M. The KEGG database. Novartis Found Symp, 2002, 247, 91-101. discussion 101-103, 119-128, 244-152.
[http://dx.doi.org/10.1002/0470857897.ch8]
[28]
Peng, H.; Long, F.; Ding, C. Feature selection based on mutual information: criteria of max-dependency, max-relevance, and min-redundancy. IEEE Trans. Pattern Anal. Mach. Intell., 2005, 27(8), 1226-1238.
[http://dx.doi.org/10.1109/TPAMI.2005.159] [PMID: 16119262]
[29]
Xiang, Q.; Feng, K.; Liao, B.; Liu, Y.; Huang, G. Prediction of lysine malonylation sites based on pseudo amino acid. Comb. Chem. High Throughput Screen., 2017, 20(7), 622-628.
[http://dx.doi.org/10.2174/1386207320666170314102647] [PMID: 28292251]
[30]
Abdel-Hafiz, H.A.; Horwitz, K.B. Post-translational modifications of the progesterone receptors. J. Steroid Biochem. Mol. Biol., 2014, 140, 80-89.
[http://dx.doi.org/10.1016/j.jsbmb.2013.12.008] [PMID: 24333793]
[31]
Du, Y.; Cai, T.; Li, T.; Xue, P.; Zhou, B.; He, X.; Wei, P.; Liu, P.; Yang, F.; Wei, T. Lysine malonylation is elevated in type 2 diabetic mouse models and enriched in metabolic associated proteins. Mol. Cell. Proteomics, 2015, 14(1), 227-236.
[http://dx.doi.org/10.1074/mcp.M114.041947] [PMID: 25418362]
[32]
Wang, S.; Li, J.; Sun, X.; Zhang, Y-H.; Huang, T.; Cai, Y. Computational method for identifying malonylation sites by using random forest algorithm. Comb. Chem. High Throughput Screen., 2020, 23(4), 304-312.
[http://dx.doi.org/10.2174/1386207322666181227144318] [PMID: 30588879]
[33]
Breiman, L. Random forests. Mach. Learn., 2001, 45, 5-32.
[http://dx.doi.org/10.1023/A:1010933404324]
[34]
Maninis, K-K.; Pont-Tuset, J.; Arbeláez, P.; Van Gool, L. Deep retinal image understanding. In: International Conference on Medical Image Computing and Computer-Assisted Intervention, 2016, pp. 140-148.
[35]
Patton, N.; Aslam, T.M.; MacGillivray, T.; Deary, I.J.; Dhillon, B.; Eikelboom, R.H.; Yogesan, K.; Constable, I.J. Retinal image analysis: concepts, applications and potential. Prog. Retin. Eye Res., 2006, 25(1), 99-127.
[http://dx.doi.org/10.1016/j.preteyeres.2005.07.001] [PMID: 16154379]
[36]
Zhang, X.; Chen, W.; Li, G.; Li, W. The use of texture features to extract and analyze useful information from retinal images. Comb. Chem. High Throughput Screen., 2019, 23, 313-318.
[http://dx.doi.org/10.2174/1386207322666191022123445] [PMID: 31642771]
[37]
Fatma, N.; Singh, D.P.; Shinohara, T.; Chylack, L.T. Jr Transcriptional regulation of the antioxidant protein 2 gene, a thiol-specific antioxidant, by lens epithelium-derived growth factor to protect cells from oxidative stress. J. Biol. Chem., 2001, 276(52), 48899-48907.
[http://dx.doi.org/10.1074/jbc.M100733200] [PMID: 11677226]
[38]
Lobo, V.; Patil, A.; Phatak, A.; Chandra, N. Free radicals, antioxidants and functional foods: Impact on human health. Pharmacogn. Rev., 2010, 4(8), 118-126.
[http://dx.doi.org/10.4103/0973-7847.70902] [PMID: 22228951]
[39]
Tong, H.; Zhang, X.; Meng, X.; Lu, L.; Mai, D.; Qu, S. Simvastatin inhibits activation of NADPH oxidase/p38 MAPK pathway and enhances expression of antioxidant protein in Parkinson disease models. Front. Mol. Neurosci., 2018, 11, 165.
[http://dx.doi.org/10.3389/fnmol.2018.00165] [PMID: 29872377]
[40]
Xu, Y.; Wen, Y.; Han, G. Antioxidant proteins identification based on support vector machine. Comb. Chem. High Throughput Screen., 2020, 23, 319-325.
[http://dx.doi.org/10.2174/1386207323666200306125538] [PMID: 32141416]
[41]
Reich, D.E.; Schaffner, S.F.; Daly, M.J.; McVean, G.; Mullikin, J.C.; Higgins, J.M.; Richter, D.J.; Lander, E.S.; Altshuler, D. Human genome sequence variation and the influence of gene history, mutation and recombination. Nat. Genet., 2002, 32(1), 135-142.
[http://dx.doi.org/10.1038/ng947] [PMID: 12161752]
[42]
Mills, R.E.; Luttig, C.T.; Larkins, C.E.; Beauchamp, A.; Tsui, C.; Pittard, W.S.; Devine, S.E. An initial map of insertion and deletion (INDEL) variation in the human genome. Genome Res., 2006, 16(9), 1182-1190.
[http://dx.doi.org/10.1101/gr.4565806] [PMID: 16902084]
[43]
Li, N.; Yang, J.; Zhu, W.; Liang, Y. MVSC: a multi-variation simulator of cancer genome. Comb. Chem. High Throughput Screen., 2020, 23(4), 326-333.

© 2025 Bentham Science Publishers | Privacy Policy
Request history8.2.27PHP Version420msRequest Duration28MBMemory UsageGET article/{article_id}/{param?}Route
  • warninglog[17:54:51] LOG.warning: Optional parameter $article_id declared before required parameter $request i...
  • warninglog[17:54:52] LOG.warning: trim(): Passing null to parameter #1 ($string) of type string is deprecated ...
  • warninglog[17:54:52] LOG.warning: Function strftime() is deprecated in /home/alphaeurekaselec/public_html/stor...
  • Booting (133ms)time
  • Application (287ms)time
  • 1 x Application (68.32%)
    287ms
    1 x Booting (31.68%)
    133ms
    14 templates were rendered
    • articlearticle.blade.php#?blade
    • includes.article_top_bannerarticle_top_banner.blade.php#?blade
    • includes.article_referencearticle_reference.blade.php#?blade
    • export_citation_formexport_citation_form.blade.php#?blade
    • includes.article_bottom_bannerarticle_bottom_banner.blade.php#?blade
    • includes.inc_related_journalsinc_related_journals.blade.php#?blade
    • includes.inc_related_ebooksinc_related_ebooks.blade.php#?blade
    • includes.journal_rightmenujournal_rightmenu.blade.php#?blade
    • includes.journal_right_bannerjournal_right_banner.blade.php#?blade
    • layouts.appapp.blade.php#?blade
    • layouts._login_access_login_access.blade.php#?blade
    • layouts._header_header.blade.php#?blade
    • layouts._main_menu_main_menu.blade.php#?blade
    • layouts._footer_menu_footer_menu.blade.php#?blade
    uri
    GET article/{article_id}/{param?}
    middleware
    web, check_user_access
    controller
    App\Http\Controllers\ArticleController@GetArticleDetails
    namespace
    App\Http\Controllers
    where
    as
    article
    file
    app/Http/Controllers/ArticleController.php:1974-2510
    32 statements were executed, 4 of which were duplicates, 28 unique. Show only duplicated197ms
    • Connection Establishedalphaeurekaselec_live_10_06_2022UserAccessCheck.php#24
      Backtrace
      • 9. middleware::check_user_access:24
      • 10. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
      • 11. vendor/laravel/framework/src/Illuminate/Routing/Middleware/SubstituteBindings.php:50
      • 12. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
      • 13. vendor/laravel/framework/src/Illuminate/Foundation/Http/Middleware/VerifyCsrfToken.php:88
    • INSERT INTO visitor_ip_address (ip_address,visitor_agent,visitor_count, created_on,updated_on) VALUES ('314520269','',1,1739987691,1739987691) ON DUPLICATE KEY UPDATE visitor_count=visitor_count + 1, updated_on=1739987691
      1.13msalphaeurekaselec_live_10_06_2022UserAccessCheck.php#24
      Backtrace
      • 11. middleware::check_user_access:24
      • 12. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
      • 13. vendor/laravel/framework/src/Illuminate/Routing/Middleware/SubstituteBindings.php:50
      • 14. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
      • 15. vendor/laravel/framework/src/Illuminate/Foundation/Http/Middleware/VerifyCsrfToken.php:88
    • INSERT INTO visitor_ip_address_detail (ip_address,visitor_url,visitor_count, created_on,updated_on) VALUES ('314520269','/article/105742',1,1739987691,1739987691)
      220μsalphaeurekaselec_live_10_06_2022UserAccessCheck.php#27
      Backtrace
      • 11. middleware::check_user_access:27
      • 12. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
      • 13. vendor/laravel/framework/src/Illuminate/Routing/Middleware/SubstituteBindings.php:50
      • 14. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
      • 15. vendor/laravel/framework/src/Illuminate/Foundation/Http/Middleware/VerifyCsrfToken.php:88
    • (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_journal_volume_trail WHERE to_ip >= 314520269 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 314520269) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_journal_volume_corporate WHERE to_ip >= 314520269 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 314520269) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_journal_volume_token WHERE to_ip >= 314520269 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 314520269) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_ebook_volume_trail WHERE to_ip >= 314520269 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 314520269) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_ebook_volume_corporate WHERE to_ip >= 314520269 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 314520269) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_ebook_volume_token WHERE to_ip >= 314520269 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 314520269) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_issue_trail WHERE to_ip >= 314520269 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 314520269) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_issue_corporate WHERE to_ip >= 314520269 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 314520269) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_issue_token WHERE to_ip >= 314520269 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 314520269) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_article_trail WHERE to_ip >= 314520269 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 314520269) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_article_corporate WHERE to_ip >= 314520269 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 314520269) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_article_token WHERE to_ip >= 314520269 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 314520269) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_chapter_trail WHERE to_ip >= 314520269 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 314520269) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_chapter_corporate WHERE to_ip >= 314520269 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 314520269) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_chapter_token WHERE to_ip >= 314520269 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 314520269) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_disease_corporate WHERE to_ip >= 314520269 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 314520269) limit 1
      11.74msalphaeurekaselec_live_10_06_2022UserAccess.php#784
      Bindings
      • 0: 314520269
      • 1: 314520269
      • 2: 314520269
      • 3: 314520269
      • 4: 314520269
      • 5: 314520269
      • 6: 314520269
      • 7: 314520269
      • 8: 314520269
      • 9: 314520269
      • 10: 314520269
      • 11: 314520269
      • 12: 314520269
      • 13: 314520269
      • 14: 314520269
      • 15: 314520269
      Backtrace
      • 14. app/Models/UserAccess/UserAccess.php:784
      • 15. middleware::check_user_access:114
      • 16. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Middleware/SubstituteBindings.php:50
      • 18. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
    • SELECT at.type_name, p.copyright, p.publisher_location,m.month,y.year, a.publish_on, a.nid article_nid,a.article_id, a.pmid, a.issue_id, a.title, a.abstract,a.podcast,a.altmetric_score,a.altmetric_url,a.kudos_url, a.page_count, a.first_page, a.elocator, a.last_page, i.publication_date, a.file_name, a.file_path, a.doi, a.is_epub,a.epub_type, a.volume_id, a.is_uploaded, a.editor_choice, a.is_epub, j.image_file_name, a.article_no, a.art_type AS article_type, a.supplementary_filename,a.html_filename,a.prc_filename,a.epub_filename, a.graph_abs_lg_filename, a.graph_abs_sm_filename, a.oa_image_lg_filename, a.oa_image_sm_filename, j.journal_banner,a.animated_abstract,a.erratum_in,a.erratum_for, (CASE WHEN a.issue_id =0 THEN j.epub_price ELSE j.price END) AS sell_price, j.epub_price, j.nid AS jour_nid, j.title AS journal_title, j.issn, j.eissn,j.journal_id, j.subtitle AS jour_subtitle, v.volume_id,v.volume_name AS volume, v.year_id, i.title AS issue, i.month_id ,i.type issue_type, j.subtitle,j.formerly_title, ac.subtitle AS epub_title,a.crossmark_enabled,a.text_mining_urls,a.license_urls,a.created, a.receivedate, a.revisedate, a.acceptdate,js.js_title FROM article a LEFT JOIN article_section ac ON a.is_epub = ac.art_sec_id LEFT JOIN journal_section js ON a.js_id = js.js_id LEFT JOIN article_type at ON a.art_type = at.art_type_id LEFT JOIN issue i ON a.issue_id = i.issue_id LEFT JOIN month m ON m.id = i.month_id LEFT JOIN volume v ON v.volume_id = a.volume_id INNER JOIN year y ON y.id = v.year_id INNER JOIN journal j ON j.journal_id = a.journal_id INNER JOIN publisher p ON p.publisher_id = j.publisher_id WHERE a.article_id=105742
      730μsalphaeurekaselec_live_10_06_2022Article.php#408
      Backtrace
      • 11. app/Models/Article.php:408
      • 12. app/Http/Controllers/ArticleController.php:2515
      • 13. app/Http/Controllers/ArticleController.php:2035
      • 14. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 15. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
    • select * from `journal` where `journal_id` = 8 limit 1
      880μsalphaeurekaselec_live_10_06_2022Journal.php#64
      Bindings
      • 0: 8
      Backtrace
      • 14. app/Models/Journal.php:64
      • 15. app/Http/Controllers/ArticleController.php:2516
      • 16. app/Http/Controllers/ArticleController.php:2035
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 18. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
    • select count(*) as aggregate from (select j.nid as journal_nid,j.flyer_link,j.title ,j.issn,j.eissn,j.keyword, j.journal_id as journal_id, j.subtitle, j.image_file_name,j.description,j.journal_insight_url,j.doi from `subject_journal` as `sj` inner join `journal` as `j` on `j`.`journal_id` = `sj`.`journal_id` where j.journal_status=1 and subject_id IN (SELECT subject_id FROM subject_journal WHERE journal_id=8) and sj.journal_id!=8 group by `j`.`nid`) as `aggregate_table`
      1.16msalphaeurekaselec_live_10_06_2022Subject.php#200
      Backtrace
      • 16. app/Models/Subject.php:200
      • 17. app/Http/Controllers/ArticleController.php:2517
      • 18. app/Http/Controllers/ArticleController.php:2035
      • 19. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 20. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
    • select j.nid as journal_nid,j.flyer_link,j.title ,j.issn,j.eissn,j.keyword, j.journal_id as journal_id, j.subtitle, j.image_file_name,j.description,j.journal_insight_url,j.doi from `subject_journal` as `sj` inner join `journal` as `j` on `j`.`journal_id` = `sj`.`journal_id` where j.journal_status=1 and subject_id IN (SELECT subject_id FROM subject_journal WHERE journal_id=8) and sj.journal_id!=8 group by `j`.`nid` order by `j`.`journal_id` asc limit 10 offset 0
      950μsalphaeurekaselec_live_10_06_2022Subject.php#200
      Backtrace
      • 14. app/Models/Subject.php:200
      • 15. app/Http/Controllers/ArticleController.php:2517
      • 16. app/Http/Controllers/ArticleController.php:2035
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 18. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
    • select count(*) as aggregate from (select v.nid as volume_id,e.nid,e.title,v.issn,v.eissn,v.isbn,v.eisbn,e.ebook_id, v.image_file_name,v.file_path,v.flyer_link,v.ebook_volume_id, v.volume_name,v.doi,v.year_id,v.introduction from `subject_ebook` as `se` inner join `ebook` as `e` on `e`.`ebook_id` = `se`.`ebook_id` inner join `ebook_volume` as `v` on `v`.`ebook_id` = `se`.`ebook_id` inner join `year` as `y` on `y`.`id` = `v`.`year_id` where subject_id IN (SELECT subject_id FROM subject_journal WHERE journal_id=8) and v.ebook_status='1' and y.year > 2020 group by `v`.`nid`) as `aggregate_table`
      2.19msalphaeurekaselec_live_10_06_2022Subject.php#220
      Backtrace
      • 16. app/Models/Subject.php:220
      • 17. app/Http/Controllers/ArticleController.php:2518
      • 18. app/Http/Controllers/ArticleController.php:2035
      • 19. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 20. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
    • select v.nid as volume_id,e.nid,e.title,v.issn,v.eissn,v.isbn,v.eisbn,e.ebook_id, v.image_file_name,v.file_path,v.flyer_link,v.ebook_volume_id, v.volume_name,v.doi,v.year_id,v.introduction from `subject_ebook` as `se` inner join `ebook` as `e` on `e`.`ebook_id` = `se`.`ebook_id` inner join `ebook_volume` as `v` on `v`.`ebook_id` = `se`.`ebook_id` inner join `year` as `y` on `y`.`id` = `v`.`year_id` where subject_id IN (SELECT subject_id FROM subject_journal WHERE journal_id=8) and v.ebook_status='1' and y.year > 2020 group by `v`.`nid` order by `v`.`ebook_volume_id` desc limit 10 offset 0
      1.98msalphaeurekaselec_live_10_06_2022Subject.php#220
      Backtrace
      • 14. app/Models/Subject.php:220
      • 15. app/Http/Controllers/ArticleController.php:2518
      • 16. app/Http/Controllers/ArticleController.php:2035
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 18. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
    • select * from `keywords` where `article_id` = '105742'
      1.83msalphaeurekaselec_live_10_06_2022Keywords.php#43
      Bindings
      • 0: 105742
      Backtrace
      • 13. app/Models/Keywords.php:43
      • 14. app/Http/Controllers/ArticleController.php:2519
      • 15. app/Http/Controllers/ArticleController.php:2035
      • 16. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 17. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
    • select * from `article_citation` where `article_id` = '105742'
      3.98msalphaeurekaselec_live_10_06_2022Article.php#1570
      Bindings
      • 0: 105742
      Backtrace
      • 13. app/Models/Article.php:1570
      • 14. app/Http/Controllers/ArticleController.php:2520
      • 15. app/Http/Controllers/ArticleController.php:2035
      • 16. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 17. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
    • select CONCAT_WS(' ',au.first_name, ' ', ifnull(au.initials,''), ' ', au.last_name) as authors, CONCAT(au.last_name, IFNULL(CONCAT(' ', au.initials), ''), ' ', au.first_name) AS authorsRIS, CONCAT_WS(' ',au.last_name, ' ', ifnull(au.initials,''), ' ', au.first_name) as authorsCiteAs, CONCAT_WS(' ',au.first_name, IFNULL(CONCAT(' ', au.initials), ''), IFNULL(CONCAT(' ', au.last_name), '')) as authorsmodal , `au`.*, `af`.`ror_id`, `af`.`institution`, `af`.`department`, `af`.`country`, `af`.`city`, `af`.`address`, (GROUP_CONCAT(TRIM(BOTH ', ' FROM CONCAT(ifnull(concat(af.institution,','),''), ifnull(concat(af.department,','),''), ifnull(concat(af.address,','),''), ifnull(concat(af.city,','),''), ifnull(concat(af.country,','),''), ifnull(concat(af.postal_code,','),''), ifnull(concat(af.phone,','),''), ifnull(concat(af.fax,','),''))) SEPARATOR '|')) as `author_affiliation`, (GROUP_CONCAT(TRIM(BOTH ', ' FROM CONCAT(ifnull(concat(af.web_view,','),''))) SEPARATOR '|')) as `web_view` from `author` as `au` left join `author_affiliation` as `af` on `au`.`author_id` = `af`.`author_id` where `au`.`article_id` = '105742' group by `au`.`author_id` order by `au`.`article_id` asc, `au`.`sequence` asc
      2.84msalphaeurekaselec_live_10_06_2022Author.php#86
      Bindings
      • 0: 105742
      Backtrace
      • 13. app/Models/Author.php:86
      • 14. app/Http/Controllers/ArticleController.php:2533
      • 15. app/Http/Controllers/ArticleController.php:2035
      • 16. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 17. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
    • select `bo`.* from `bundle_offer` as `bo` where `bo`.`bundle_status` = 'A' order by `bo`.`bundle_id` desc
      320μsalphaeurekaselec_live_10_06_2022BundleOffer.php#57
      Bindings
      • 0: A
      Backtrace
      • 13. app/Models/BundleOffer.php:57
      • 14. app/Http/Controllers/ArticleController.php:2535
      • 15. app/Http/Controllers/ArticleController.php:2035
      • 16. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 17. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
    • select `subtitle` from `journal` where `continues_publication_journal` = 1
      670μsalphaeurekaselec_live_10_06_2022Article.php#1960
      Bindings
      • 0: 1
      Backtrace
      • 13. app/Models/Article.php:1960
      • 14. app/Http/Controllers/ArticleController.php:2062
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • Select j.subtitle, v.volume_id as volume_id,v.year_id,y.year as year,v.volume_name, v.total_no_of_issues, i.issue_id as issue_id,i.title as issue, i.publication_date as issue_pub_date from journal j join volume v on j.journal_id = v.journal_id join issue i on v.volume_id = i.volume_id join article a on a.issue_id = i.issue_id join year y on v.year_id = y.id where j.journal_id = 8 and i.is_uploaded = 1 order by v.volume_name+0 desc, i.title+0 desc limit 1
      46.34msalphaeurekaselec_live_10_06_2022Issue.php#298
      Backtrace
      • 11. app/Models/Issue.php:298
      • 12. app/Http/Controllers/ArticleController.php:2068
      • 13. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 14. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select a.nid,a.publish_on, a.pmid,a.article_id,a.doi,j.journal_id,j.subtitle,v.volume_name,a.volume_id as volume_id, a.issue_id,a.title,first_page, last_page, page_count,abstract,ifnull(is_abstract,"y"),asec.title as article_section,at.type_name as article_type_name, a.article_id as ArticleID ,is_epub,epub_price,epub_type,a.created, y.year from `article` as `a` left join `article_section` as `asec` on `asec`.`art_sec_id` = `a`.`is_epub` left join `article_type` as `at` on `at`.`art_type_id` = `a`.`art_type` left join `journal` as `j` on `j`.`journal_id` = `a`.`journal_id` inner join `volume` as `v` on `a`.`volume_id` = `v`.`volume_id` inner join `year` as `y` on `v`.`year_id` = `y`.`id` where a.article_status != "W" and a.is_epub = 1 and a.journal_id = 8 and a.is_uploaded = 1 group by `a`.`article_id` order by `a`.`publish_on` desc
      34.34msalphaeurekaselec_live_10_06_2022Article.php#528
      Backtrace
      • 13. app/Models/Article.php:528
      • 14. app/Http/Controllers/ArticleController.php:2070
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select a.nid,a.publish_on, a.pmid,a.article_id,a.doi,j.journal_id,j.subtitle,v.volume_name,a.volume_id as volume_id, a.issue_id,a.title,first_page, last_page, page_count,abstract,ifnull(is_abstract,"y"),asec.title as article_section,at.type_name as article_type_name, a.article_id as ArticleID ,is_epub,epub_price,epub_type,a.created, y.year from `article` as `a` left join `article_section` as `asec` on `asec`.`art_sec_id` = `a`.`is_epub` left join `article_type` as `at` on `at`.`art_type_id` = `a`.`art_type` left join `journal` as `j` on `j`.`journal_id` = `a`.`journal_id` inner join `volume` as `v` on `a`.`volume_id` = `v`.`volume_id` inner join `year` as `y` on `v`.`year_id` = `y`.`id` where a.article_status != "W" and a.is_epub = 4 and a.journal_id = 8 and a.is_uploaded = 1 group by `a`.`article_id` order by `a`.`publish_on` desc
      15.81msalphaeurekaselec_live_10_06_2022Article.php#528
      Backtrace
      • 13. app/Models/Article.php:528
      • 14. app/Http/Controllers/ArticleController.php:2071
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select pdf, html, epub, prc from `article_metrics` where `article_id` = 105742 limit 1
      270μsalphaeurekaselec_live_10_06_2022Article.php#744
      Bindings
      • 0: 105742
      Backtrace
      • 14. app/Models/Article.php:744
      • 15. app/Http/Controllers/ArticleController.php:2091
      • 16. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 17. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 18. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select * from content_by_diseases where content_id = 105742 and content_type = 'article' order by status desc limit 1
      610μsalphaeurekaselec_live_10_06_2022Article.php#751
      Backtrace
      • 11. app/Models/Article.php:751
      • 12. app/Http/Controllers/ArticleController.php:2094
      • 13. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 14. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select a.nid article_nid,a.title article_title,j.title journal_title from content_by_diseases cd inner join article a on a.article_id=cd.content_id inner join journal j on j.journal_id=a.journal_id where cd.pid = 258 and cd.sub_disease_id = 402 and content_id!=105742 and cd.content_type = 'article' order by rand() limit 20
      62.37msalphaeurekaselec_live_10_06_2022Article.php#769
      Backtrace
      • 11. app/Models/Article.php:769
      • 12. app/Http/Controllers/ArticleController.php:2098
      • 13. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 14. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select * from `node_meta` where `nid` = 180809 limit 1
      230μsalphaeurekaselec_live_10_06_2022Meta.php#30
      Bindings
      • 0: 180809
      Backtrace
      • 14. app/Models/Meta.php:30
      • 15. app/Http/Controllers/ArticleController.php:2101
      • 16. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 17. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 18. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select `bo`.* from `bundle_offer` as `bo` where `bo`.`bundle_status` = 'A' order by `bo`.`bundle_id` desc
      240μsalphaeurekaselec_live_10_06_2022BundleOffer.php#57
      Bindings
      • 0: A
      Backtrace
      • 13. app/Models/BundleOffer.php:57
      • 14. app/Http/Controllers/ArticleController.php:2108
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select * from `tbl_ht_submission` as `h` where `h`.`subtitle` = 'CCHTS' and (h.proposal_closing_date = 0 OR TO_DAYS(FROM_UNIXTIME(h.proposal_closing_date)) >= TO_DAYS(NOW())) order by `h`.`manuscript` asc
      270μsalphaeurekaselec_live_10_06_2022Article.php#2025
      Bindings
      • 0: CCHTS
      Backtrace
      • 13. app/Models/Article.php:2025
      • 14. app/Http/Controllers/ArticleController.php:2112
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select count(*) as total_count, content_type_access_id as access_type from journal_access where content_type_id = '105742' and content_type = 'a' and ( (from_date <= CURDATE() and to_date >= CURDATE() and perpetual= 0) or (from_date is null and to_date is null and perpetual= 1) )
      350μsalphaeurekaselec_live_10_06_2022ContentAccess.php#647
      Backtrace
      • 11. app/Models/ContentAccess.php:647
      • 12. app/Http/Controllers/ArticleController.php:2186
      • 13. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 14. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select * from `article` where `first_page` < '270' and is_uploaded = 1 and issue_id = 9786 order by cast(first_page as SIGNED) desc limit 1
      430μsalphaeurekaselec_live_10_06_2022Article.php#1819
      Bindings
      • 0: 270
      Backtrace
      • 14. app/Models/Article.php:1819
      • 15. app/Http/Controllers/ArticleController.php:2470
      • 16. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 17. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 18. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select * from `article` where `last_page` > '273' and is_uploaded = 1 and issue_id = 9786 order by cast(first_page as SIGNED) asc limit 1
      440μsalphaeurekaselec_live_10_06_2022Article.php#1831
      Bindings
      • 0: 273
      Backtrace
      • 14. app/Models/Article.php:1831
      • 15. app/Http/Controllers/ArticleController.php:2472
      • 16. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 17. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 18. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select `language_id` from `multilanguage` where `short_code` = 'en'
      170μsalphaeurekaselec_live_10_06_2022ArticleController.php#2497
      Bindings
      • 0: en
      Backtrace
      • 14. app/Http/Controllers/ArticleController.php:2497
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
      • 18. vendor/laravel/framework/src/Illuminate/Routing/Route.php:206
    • select `source_lang_label`, `target_lang_label` from `multilanguage_labels` where `target_lang_id` = 1
      170μsalphaeurekaselec_live_10_06_2022MultiLanguage.php#23
      Bindings
      • 0: 1
      Backtrace
      • 13. app/Models/MultiLanguage.php:23
      • 14. app/Http/Controllers/ArticleController.php:2498
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select `id` from `multilanguage_article` where `article_id` = 105742 limit 1
      2.38msalphaeurekaselec_live_10_06_2022ArticleController.php#2506
      Bindings
      • 0: 105742
      Backtrace
      • 16. app/Http/Controllers/ArticleController.php:2506
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 18. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 19. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
      • 20. vendor/laravel/framework/src/Illuminate/Routing/Route.php:206
    • select b.banner_link, b.banner_name, b.banner_script, b.banner_remarks, b.banner_file_name, b.banner_placement, bd.content_type, bd.content_id from `tbl_banner` as `b` inner join `tbl_banner_detail` as `bd` on `bd`.`banner_id` = `b`.`banner_id` inner join `users` as `u` on `u`.`id` = `b`.`updated_by` inner join `journal` as `j` on `j`.`journal_id` = `bd`.`content_id` where `b`.`banner_journal` = 1 and `bd`.`content_type` = 'J' and `bd`.`content_id` = 8 and `b`.`banner_from_date` <= 1739987692 and `b`.`banner_to_date` >= 1739987692 and `b`.`banner_status` = 'A' order by `b`.`banner_id` desc
      1.12msalphaeurekaselec_live_10_06_2022Banner.php#95
      Bindings
      • 0: 1
      • 1: J
      • 2: 8
      • 3: 1739987692
      • 4: 1739987692
      • 5: A
      Backtrace
      • 13. app/Models/Banner.php:95
      • 14. app/Http/helpers.php:404
      • 17. vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:124
      • 18. vendor/laravel/framework/src/Illuminate/View/Engines/PhpEngine.php:58
      • 19. vendor/laravel/framework/src/Illuminate/View/Engines/CompilerEngine.php:73
    • select b.banner_link, b.banner_name, b.banner_script, b.banner_remarks, b.banner_file_name, b.banner_placement, bd.content_type, bd.content_id from `tbl_banner` as `b` inner join `tbl_banner_detail` as `bd` on `bd`.`banner_id` = `b`.`banner_id` inner join `users` as `u` on `u`.`id` = `b`.`updated_by` inner join `journal` as `j` on `j`.`journal_id` = `bd`.`content_id` where `b`.`banner_journal` = 1 and `bd`.`content_type` = 'J' and `bd`.`content_id` = 8 and `b`.`banner_from_date` <= 1739987692 and `b`.`banner_to_date` >= 1739987692 and `b`.`banner_status` = 'A' order by `b`.`banner_id` desc
      1.04msalphaeurekaselec_live_10_06_2022Banner.php#95
      Bindings
      • 0: 1
      • 1: J
      • 2: 8
      • 3: 1739987692
      • 4: 1739987692
      • 5: A
      Backtrace
      • 13. app/Models/Banner.php:95
      • 14. app/Http/helpers.php:404
      • 17. vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:124
      • 18. vendor/laravel/framework/src/Illuminate/View/Engines/PhpEngine.php:58
      • 19. vendor/laravel/framework/src/Illuminate/View/Engines/CompilerEngine.php:73
    • select count(*) as aggregate from `uc_cart_products` where cart_id='d3dc53de6833ffd7e3a40b1c457fe7e6'
      210μsalphaeurekaselec_live_10_06_2022Cart.php#271
      Backtrace
      • 15. app/Models/Cart.php:271
      • 16. view::layouts._header:260
      • 18. vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:124
      • 19. vendor/laravel/framework/src/Illuminate/View/Engines/PhpEngine.php:58
      • 20. vendor/laravel/framework/src/Illuminate/View/Engines/CompilerEngine.php:73
    App\Models\MultiLanguage
    1MultiLanguage.php#?
        _token
        EYIRiFvPkvQtInUCTbfSPUT8HZXMPzrFsjUKN0Bw
        uc_cart_id
        d3dc53de6833ffd7e3a40b1c457fe7e6
        _previous
        array:1 [ "url" => "http://alpha.eurekaselect.com/article/105742" ]
        _flash
        array:2 [ "old" => [] "new" => [] ]
        PHPDEBUGBAR_STACK_DATA
        []
        path_info
        /article/105742
        status_code
        200
        
        status_text
        OK
        format
        html
        content_type
        text/html; charset=UTF-8
        request_query
        []
        
        request_request
        []
        
        request_headers
        0 of 0
        array:8 [ "accept-encoding" => array:1 [ 0 => "gzip, deflate" ] "accept" => array:1 [ 0 => "text/html,application/xhtml+xml,application/xml;q=0.9,image/avif,image/webp,image/apng,*/*;q=0.8,application/signed-exchange;v=b3;q=0.7" ] "user-agent" => array:1 [ 0 => "Mozilla/5.0 AppleWebKit/537.36 (KHTML, like Gecko; compatible; ClaudeBot/1.0; +claudebot@anthropic.com)" ] "upgrade-insecure-requests" => array:1 [ 0 => "1" ] "cache-control" => array:1 [ 0 => "no-cache" ] "pragma" => array:1 [ 0 => "no-cache" ] "connection" => array:1 [ 0 => "keep-alive" ] "host" => array:1 [ 0 => "alpha.eurekaselect.com" ] ]
        request_cookies
        []
        
        response_headers
        0 of 0
        array:5 [ "content-type" => array:1 [ 0 => "text/html; charset=UTF-8" ] "cache-control" => array:1 [ 0 => "no-cache, private" ] "date" => array:1 [ 0 => "Wed, 19 Feb 2025 17:54:52 GMT" ] "set-cookie" => array:2 [ 0 => "XSRF-TOKEN=eyJpdiI6IkF6MDJVOS9sZmp5MFhJOUN0Mm1KUXc9PSIsInZhbHVlIjoiNGRyeXdmb2VCVGFDNzc1Z1AyWjM1K0FISktUWTlpeVR3azhya2VBWnNQVVpSUkxocTcxaE5ZMlVMcWVHZHJtTXRmM3Uxc1JWR3NicW1FTzBHSWRyQjBHSGxtV0V4V29acU9rSWdKb2M0dFNCVElyYjlodWpnMUpBNDVjNVBwTTUiLCJtYWMiOiIwYzdhNjZiZWM2MDRhYzhkMjYzOGUyZmRhYzgzNDhmNGY0Y2ZjZWQ5ODAyOWMyZDVlMmVmZWY4MDFlMmQ1OGQwIiwidGFnIjoiIn0%3D; expires=Sat, 22 Feb 2025 05:54:52 GMT; Max-Age=216000; path=/; secure; samesite=laxXSRF-TOKEN=eyJpdiI6IkF6MDJVOS9sZmp5MFhJOUN0Mm1KUXc9PSIsInZhbHVlIjoiNGRyeXdmb2VCVGFDNzc1Z1AyWjM1K0FISktUWTlpeVR3azhya2VBWnNQVVpSUkxocTcxaE5ZMlVMcWVHZHJtTXRmM3Uxc" 1 => "alphaeurekaselectnet_session=eyJpdiI6ImhQK2dmZlY4UVRKa3R6eXdQRjJzM2c9PSIsInZhbHVlIjoiUzgzRGVzZ0h1Q05FSm03YTRWT2xEZTd2Z3RUTWdKS0ZuUStjOURZcmQwVU1TNEl6TytWeEpWWFVOMlFMTFBkSkNQZjlsd2FBS3N1SC9NOHBoZDQ2OStoRURxekVLSVlPYUwrczgybEtJNmp2VmtEZDRSTytiZTRyWDV5K0I3c1AiLCJtYWMiOiJkMDg2YTBlMzU2YjBkNTAzMGZiODE5NzViMGRiMjhkYTEzMTlmNDU0ZTAyZTFjYzQzNTU0YzJhODBjNzdiZmQyIiwidGFnIjoiIn0%3D; path=/; secure; httponly; samesite=laxalphaeurekaselectnet_session=eyJpdiI6ImhQK2dmZlY4UVRKa3R6eXdQRjJzM2c9PSIsInZhbHVlIjoiUzgzRGVzZ0h1Q05FSm03YTRWT2xEZTd2Z3RUTWdKS0ZuUStjOURZcmQwVU1TNEl6TytWeEpWWFV" ] "Set-Cookie" => array:2 [ 0 => "XSRF-TOKEN=eyJpdiI6IkF6MDJVOS9sZmp5MFhJOUN0Mm1KUXc9PSIsInZhbHVlIjoiNGRyeXdmb2VCVGFDNzc1Z1AyWjM1K0FISktUWTlpeVR3azhya2VBWnNQVVpSUkxocTcxaE5ZMlVMcWVHZHJtTXRmM3Uxc1JWR3NicW1FTzBHSWRyQjBHSGxtV0V4V29acU9rSWdKb2M0dFNCVElyYjlodWpnMUpBNDVjNVBwTTUiLCJtYWMiOiIwYzdhNjZiZWM2MDRhYzhkMjYzOGUyZmRhYzgzNDhmNGY0Y2ZjZWQ5ODAyOWMyZDVlMmVmZWY4MDFlMmQ1OGQwIiwidGFnIjoiIn0%3D; expires=Sat, 22-Feb-2025 05:54:52 GMT; path=/; secureXSRF-TOKEN=eyJpdiI6IkF6MDJVOS9sZmp5MFhJOUN0Mm1KUXc9PSIsInZhbHVlIjoiNGRyeXdmb2VCVGFDNzc1Z1AyWjM1K0FISktUWTlpeVR3azhya2VBWnNQVVpSUkxocTcxaE5ZMlVMcWVHZHJtTXRmM3Uxc" 1 => "alphaeurekaselectnet_session=eyJpdiI6ImhQK2dmZlY4UVRKa3R6eXdQRjJzM2c9PSIsInZhbHVlIjoiUzgzRGVzZ0h1Q05FSm03YTRWT2xEZTd2Z3RUTWdKS0ZuUStjOURZcmQwVU1TNEl6TytWeEpWWFVOMlFMTFBkSkNQZjlsd2FBS3N1SC9NOHBoZDQ2OStoRURxekVLSVlPYUwrczgybEtJNmp2VmtEZDRSTytiZTRyWDV5K0I3c1AiLCJtYWMiOiJkMDg2YTBlMzU2YjBkNTAzMGZiODE5NzViMGRiMjhkYTEzMTlmNDU0ZTAyZTFjYzQzNTU0YzJhODBjNzdiZmQyIiwidGFnIjoiIn0%3D; path=/; secure; httponlyalphaeurekaselectnet_session=eyJpdiI6ImhQK2dmZlY4UVRKa3R6eXdQRjJzM2c9PSIsInZhbHVlIjoiUzgzRGVzZ0h1Q05FSm03YTRWT2xEZTd2Z3RUTWdKS0ZuUStjOURZcmQwVU1TNEl6TytWeEpWWFV" ] ]
        session_attributes
        0 of 0
        array:5 [ "_token" => "EYIRiFvPkvQtInUCTbfSPUT8HZXMPzrFsjUKN0Bw" "uc_cart_id" => "d3dc53de6833ffd7e3a40b1c457fe7e6" "_previous" => array:1 [ "url" => "http://alpha.eurekaselect.com/article/105742" ] "_flash" => array:2 [ "old" => [] "new" => [] ] "PHPDEBUGBAR_STACK_DATA" => [] ]
        ClearShow all
        Date ↕MethodURLData
        #12025-02-19 17:54:52GET/article/105742314321