Abstract
The consumption of fish and omega-3 fatty acids has been associated with reduced morbidity and mortality from coronary heart disease. The precise mechanisms by which fatty acids modulate atherosclerotic vascular disease remain to be defined. Experimental evidence suggests that fatty acids alter the function of the vascular endothelium, a metabolically active tissue that integrates signals between the circulation and the vascular wall. This review focuses on the effects of fatty acids on vascular endothelial nitric oxide production. Endothelial-derived nitric oxide regulates several vascular wall events that participate in the evolution of vascular disease. Impairment of endothelial nitric oxide production has been demonstrated in a variety of conditions such as smoking, diabetes, and hypertension that are risk factors for atherosclerosis. Evidence is reviewed that supports the postulate that both qualitative and quantitative alterations in circulating fatty acid species modulate vascular endothelial nitric oxide production. Although the mechanisms by which fatty acids alter vascular nitric oxide production remain obscure, fatty acid-mediated alterations in endothelial gene expression present a promising area for future investigation.
Current Organic Chemistry
Title: Regulation of Vascular Endothelial Nitric Oxide Production by Fatty Acids
Volume: 4 Issue: 11
Author(s): David S. Calnek and C. Michael Hart
Affiliation:
Abstract: The consumption of fish and omega-3 fatty acids has been associated with reduced morbidity and mortality from coronary heart disease. The precise mechanisms by which fatty acids modulate atherosclerotic vascular disease remain to be defined. Experimental evidence suggests that fatty acids alter the function of the vascular endothelium, a metabolically active tissue that integrates signals between the circulation and the vascular wall. This review focuses on the effects of fatty acids on vascular endothelial nitric oxide production. Endothelial-derived nitric oxide regulates several vascular wall events that participate in the evolution of vascular disease. Impairment of endothelial nitric oxide production has been demonstrated in a variety of conditions such as smoking, diabetes, and hypertension that are risk factors for atherosclerosis. Evidence is reviewed that supports the postulate that both qualitative and quantitative alterations in circulating fatty acid species modulate vascular endothelial nitric oxide production. Although the mechanisms by which fatty acids alter vascular nitric oxide production remain obscure, fatty acid-mediated alterations in endothelial gene expression present a promising area for future investigation.
Export Options
About this article
Cite this article as:
Calnek S. David and Michael Hart C., Regulation of Vascular Endothelial Nitric Oxide Production by Fatty Acids, Current Organic Chemistry 2000; 4 (11) . https://dx.doi.org/10.2174/1385272003375888
DOI https://dx.doi.org/10.2174/1385272003375888 |
Print ISSN 1385-2728 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5348 |
Call for Papers in Thematic Issues
Catalytic C-H bond activation as a tool for functionalization of heterocycles
The major topic is the functionalization of heterocycles through catalyzed C-H bond activation. The strategies based on C-H activation not only provide straightforward formation of C-C or C-X bonds but, more importantly, allow for the avoidance of pre-functionalization of one or two of the cross-coupling partners. The beneficial impact of ...read more
Chemistry and Biology of Carbohydrates
Carbohydrates are one of the most abundant natural products and are considered to be extremely important biomolecules for their ever-increasing impact on chemistry and biology. Their role in several important biological processes, notably energy storage, transport, modulation of protein function, intercellular adhesion, malignant transformation, signal transduction, viral, and bacterial cell ...read more
Related Journals
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
HIV-Infected Patients and Liver Transplantation: Who, When and Why
Current HIV Research Translational Applications of Tissue Engineering in Cardiovascular Medicine
Current Pharmaceutical Design Fundamental Concepts of the Angiogenic Process
Current Molecular Medicine The Ubiquitin Proteasome System as a Potential Target for the Treatment of Neurodegenerative Diseases
Current Pharmaceutical Design Q Fever Endocarditis
Infectious Disorders - Drug Targets Reactive Species, Cellular Repair and Risk Factors in the Onset of Type 2 Diabetes Mellitus: Review and Hypothesis
Current Diabetes Reviews Realising Heart Regeneration
Current Tissue Engineering (Discontinued) Mean Platelet Volume During Ischemic Stroke is a Potential Pro-inflammatory Biomarker in the Acute Phase and During Neurorehabilitation Not Directly Linked to Clinical Outcome
Current Neurovascular Research Fatty Acids and Herbal Medicine
Current Traditional Medicine Role of Translocator Protein in Renal Ischemia Reperfusion, Renal Preservation and Acute Kidney Injury
Current Molecular Medicine Skeletal Muscle Derived Stem Cells for Myocardial Repair
Recent Patents on Cardiovascular Drug Discovery Prevalence and Factors Associated With Low Aerobic Performance Levels in Adolescents: A Systematic Review
Current Pediatric Reviews Lone Atrial Fibrillation- A Diagnosis of Exclusion
Current Pharmaceutical Design Current Applications of Therapeutic Gases in Neonatal Intensive Care
Current Pediatric Reviews MicroRNAs and the Heart: Small Things Do Matter
Current Topics in Medicinal Chemistry Hepatotoxicity of Antiretroviral Drugs
Current Pharmaceutical Design Flavonoids and Linderone from Lindera oxyphylla and their Bioactivities
Combinatorial Chemistry & High Throughput Screening Health Benefits of Ipecac and Cephaeline: their Potential in Health Promotion and Disease Prevention
Current Bioactive Compounds Metabolic Syndrome and Cardiometabolic Risk Factors
Current Vascular Pharmacology Treatment of Atherosclerotic Renovascular Disease
Current Hypertension Reviews