Nanoparticles as a Tool for Broadening Antifungal Activities

Daniele    Fernanda    Renzi; Laís       de Almeida Campos; Eduardo    Hösel    Miranda; Rubiana    Mara    Mainardes; Wolf-Rainer       Abraham; Diana    Fortkamp    Grigoletto; Najeh    Maissar    Khalil
doi:10.2174/0929867327666200330143338
Abstract

Fungal infections are diseases that are considered neglected although their infection rates have increased worldwide in the last decades. Thus, since the antifungal arsenal is restricted and many strains have shown resistance, new therapeutic alternatives are necessary. Nanoparticles are considered important alternatives to promote drug delivery. In this sense, the objective of the present study was to evaluate the contributions of newly developed nanoparticles to the treatment of fungal infections. Studies have shown that nanoparticles generally improve the biopharmaceutical and pharmacokinetic characteristics of antifungals, which is reflected in a greater pharmacodynamic potential and lower toxicity, as well as the possibility of prolonged action. It also offers the proposition of new routes of administration. Nanotechnology is known to contribute to a new drug delivery system, not only for the control of infectious diseases but for various other diseases as well. In recent years, several studies have emphasized its application in infectious diseases, presenting better alternatives for the treatment of fungal infections.
Keywords: Azoles, echinocandins, fungal infection, nanotechnology, polyenes, nano partice drug delivery, infectious disease.
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DOI https://dx.doi.org/10.2174/0929867327666200330143338	Print ISSN 0929-8673
Publisher Name Bentham Science Publisher	Online ISSN 1875-533X
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