Annona Genus: Traditional Uses, Phytochemistry and Biological Activities

Débora    O. D.	   Leite; Carla       de F. A. Nonato; Cicera    J.   Camilo; Natália     K. G.    de Carvalho; Mário    G. L. A.   da Nobrega; Rafael    C.   Pereira; José   G. M.    da Costa
doi:10.2174/1381612826666200325094422
Abstract

Species from the Annona (Anonaceae) genus are used in traditional medicine for the treatment of various diseases. Ethnobotanical studies provide information regarding the plant part and the preparation method being used, while scientific studies such as in vitro, in vivo, and clinical tests can provide evidence supporting ethnopharmacological reports, directing studies towards the isolation of compounds which may be active for specific pathologies. Annona muricata and Annona squamosa were the most commonly reported species from those studied, with Annona cherimola and Annona classiflora also standing out. Acetogenins were the most commonly isolated metabolite class due to their cytotoxic properties, with flavonoids, alkaloids, steroids, and peptides also being reported. Many species from the Annona genus have proven biological activities, such as antitumor, antioxidant, antimicrobial and antifungal. The present review had as its objective to facilitate access to ethnobotanical, chemical and biological information in order to direct future researches.
Keywords: Annona, ethnobotany, biological activity, isolated compounds, isolated metabolite, cytotoxic properties.
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[1] 
Awachare CM, Kurian RM, Upreti KK, Laxman RH. Morpho- physiological diversity in Annona species. Sci Hortic (Amsterdam)  2018; 234: 58-62.
[http://dx.doi.org/10.1016/j.scienta.2018.02.005] 
[2] 
Bermúdez A, Miranda MAO, Velázquez D. La investigación etnobotánica sobre plantas medicinales: una revisión de sus objetivos y enfoques actuales. Interciencia  2005; 30(8): 453-9.
[3] 
Casanova LM, Costa SS. Interações Sinérgicas em Produtos Naturais: Potencial Terapêutico e Desafios. Rev Virtual Quim  2017; 9(2): 575-95.
[http://dx.doi.org/10.21577/1984-6835.20170034] 
[4] 
Quílez AM, Fernández-Arche MA, García-Giménez MD, De la Puerta R. Potential therapeutic applications of the genus Annona: Local and traditional uses and pharmacology. J Ethnopharmacol  2018; 225: 244-70.
[http://dx.doi.org/10.1016/j.jep.2018.06.014] [PMID:  29933016] 
[5] 
Sanz-Biset J, Cañigueral S. Plant use in the medicinal practices known as “strict diets” in Chazuta valley (Peruvian Amazon). J Ethnopharmacol  2011; 137(1): 271-88.
[http://dx.doi.org/10.1016/j.jep.2011.05.021] [PMID:  21627986] 
[6] 
Calzada F, Arista R, Pérez H. Effect of plants used in Mexico to treat gastrointestinal disorders on charcoal-gum acacia-induced hyperperistalsis in rats. J Ethnopharmacol  2010; 128(1): 49-51.
[http://dx.doi.org/10.1016/j.jep.2009.12.022] [PMID:  20035855] 
[7] 
Albuquerque TG, Santos F, Sanches-Silva A, Beatriz Oliveira M, Bento AC, Costa HS. Nutritional and phytochemical composition of Annona cherimola Mill. fruits and by-products: Potential health benefits. Food Chem  2016; 193: 187-95.
[http://dx.doi.org/10.1016/j.foodchem.2014.06.044] [PMID:  26433307] 
[8] 
Soto AM, Salas PG, Pérez CR, et al. Antioxidant capacity of 44 cultivars of fruits and vegetables grown in Andalusia (Spain). Food Res Int  2014; 58: 35-46.
[http://dx.doi.org/10.1016/j.foodres.2014.01.050] 
[9] 
Loizzo MR, Tundis R, Bonesi M, et al. Radical scavenging, antioxidant and metal chelating activities of Annona cherimola Mill. (cherimoya) peel and pulp in relation to their total phenolic and total flavonoid contents. J Food Compos Anal  2012; 25: 179-84.
[http://dx.doi.org/10.1016/j.jfca.2011.09.002] 
[10] 
Elera GG, Garrett AR, Martinez A, Robison RA, O’Neill KL. The antioxidant properties of the cherimoya (Annona cherimola) fruit. Food Res Int  2011; 44: 2205-9.
[http://dx.doi.org/10.1016/j.foodres.2010.10.038] 
[11] 
Barreca D, Laganà G, Ficarra S, et al. Evaluation of the antioxidant and cytoprotective properties of the exotic fruit Annona cherimola Mill. (Annonaceae). Food Res Int  2011; 44: 2302-10.
[http://dx.doi.org/10.1016/j.foodres.2011.02.031] 
[12] 
Falé PL, Ferreira C, Maruzzella F, Helena Florêncio M, Frazão FN, Serralheiro MLM. Evaluation of cholesterol absorption and biosynthesis by decoctions of Annona cherimola leaves. J Ethnopharmacol  2013; 150(2): 718-23.
[http://dx.doi.org/10.1016/j.jep.2013.09.029] [PMID:  24095697] 
[13] 
Martínez-Vázquez M, Estrada-Reyes R, Araujo Escalona AG, et al. Antidepressant-like effects of an alkaloid extract of the aerial parts of Annona cherimolia in mice. J Ethnopharmacol  2012; 139(1): 164-70.
[http://dx.doi.org/10.1016/j.jep.2011.10.033] [PMID:  22101086] 
[14] 
Fuentes YMO, Chávez Flores ECJL, Camacho SH, Ortiz JCD. Evaluación in vitro de la actividad antifúngica de cuatro extractos vegetales metanólicos para el control de tres especies de Fusarium spp. Int J Exp Bot  2012; 81: 69-73.
[15] 
Ribeiro RV, Bieski IGC, Balogun SO, Martins DTO. Ethnobotanical study of medicinal plants used by Ribeirinhos in the North Araguaia microregion, Mato Grosso, Brazil. J Ethnopharmacol  2017; 205: 69-102.
[http://dx.doi.org/10.1016/j.jep.2017.04.023] [PMID:  28476677] 
[16] 
Saraiva ME, Ulisses AVRA, Ribeiro DA, et al. Plant species as a therapeutic resource in areas of the savanna in the state of Pernambuco, Northeast Brazil. J Ethnopharmacol  2015; 171: 141-53.
[http://dx.doi.org/10.1016/j.jep.2015.05.034] [PMID:  26026371] 
[17] 
Ribeiro DA, Oliveira LGS, Macêdo DG, et al. Promising medicinal plants for bioprospection in a Cerrado area of Chapada do Araripe, Northeastern Brazil. J Ethnopharmacol  2014; 155(3): 1522-33.
[http://dx.doi.org/10.1016/j.jep.2014.07.042] [PMID:  25086410] 
[18] 
Souza RKD, da Silva MA, de Menezes IR, Ribeiro DAR, Bezerra LR, Souza MMA. Ethnopharmacology of medicinal plants of carrasco, northeastern Brazil. J Ethnopharmacol  2014; 157: 99-104.
[http://dx.doi.org/10.1016/j.jep.2014.09.001] [PMID:  25240589] 
[19] 
Siqueira CAT, Oliani J, Sartoratto A, et al. Chemical constituents of the volatile oil from leaves of Annona coriacea and in vitro antiprotozoal activity. Rev Bras Farmacogn Braz J Pharmacogn  2011; 21(1): 33-40.
[http://dx.doi.org/10.1590/S0102-695X2011005000004] 
[20] 
Formagio ASN, Vieira MC, Volobuff CRF, et al. In vitro biological screening of the anticholinesterase and antiproliferative activities of medicinal plants belonging to Annonaceae. Braz J Med Biol Res  2015; 48(4): 308-15.
[http://dx.doi.org/10.1590/1414-431x20144127] [PMID:  25714885] 
[21] 
de Toledo CE, Britta EA, Ceole LF, et al. Antimicrobial and cytotoxic activities of medicinal plants of the Brazilian cerrado, using Brazilian cachaça as extractor liquid. J Ethnopharmacol  2011; 133(2): 420-5.
[http://dx.doi.org/10.1016/j.jep.2010.10.021] [PMID:  20951786] 
[22] 
Benites RSR, Formagio ASN, Argandoña EJS, et al. Contents of constituents and antioxidant activity of seed and pulp extracts of Annona coriacea and Annona sylvatica. Braz J Biol  2015; 75(3): 685-91.
[http://dx.doi.org/10.1590/1519-6984.21313] [PMID:  26421762] 
[23] 
Carneirol AP, Pereira MJB, Galbiati C. Biocide activity of Annona coriacea seeds extract on Rhodnius neglectus (Hemiptera: Reduviidae). Rev Biol Trop  2013; 61(1): 419-27.
[PMID:  23894992] 
[24] 
Costa MS, Pinheiro DO, Serrão JE, Pereira MJB. Morphological changes in the midgut of Aedes aegypti L. (Diptera: Culicidae) larvae following exposure to an Annona coriacea (Magnoliales: Annonaceae) extract. Neotrop Entomol  2012; 41(4): 311-4.
[http://dx.doi.org/10.1007/s13744-012-0050-z] [PMID:  23950067] 
[25] 
Nascimento GNL, Valadares MC, Nishijo H, Ferreira TAA. Investigation of the toxic potential of crude ethanol extract of Annona coriacea (araticum) seeds in acute exposed mice. Rev Bras Farmacogn  2012; 22(3): 580-6.
[http://dx.doi.org/10.1590/S0102-695X2012005000015] 
[26] 
Almeida-Apolonio AA, Dantas FGDS, Rodrigues AB, et al. Atividade antifúngica de Annona coriacea Mart. extratos etanólicos contra os agentes etiológicos da criptococose. Nat Prod Res  2019; 33(16): 1-5.
[27] 
Júnior JGAS, Coutinho HD, Boris TC. José Cristo, Pereira NL, Figueiredo FG, Cunha FA, Aquino PE, Nascimento PA, Mesquita FJ, Moreira PH, ST Coutinho, Souza IT, Teixeira GC, Ferreira NM Farina EO, Torres CM, Holanda VN, Pereira VS, Guedes MI. Caracter- ização química e efeito citoprotetor do extrato hidroetanólico de Annona coriacea Mart. (Araticum) Phcog Res  2016; 8: 253-7.
[28] 
Lima LARS, Lopes MTP, Cunha MM, Pimenta LPS, Boaventura MAD. Avaliação da atividade citotóxica das sementes de Annona cornifolia A. St.-Hil. (Annonaceae). Rev Bras Pl Med  2012; 14(4): 629-34.
[http://dx.doi.org/10.1590/S1516-05722012000400009] 
[29] 
Lima LARS, Johann S, Cisalpino OS, Pimenta LPS, Boaventura MAD. Antifungal activity of 9-hydroxy-folianin and sucrose octaacetate from the seeds of Annona cornifolia A. St. -Hil. (Annonaceae). Food Res Int  2011; 44: 2283-8.
[http://dx.doi.org/10.1016/j.foodres.2010.11.030] 
[30] 
Justino AB, Pereira MN, Vilela DD, et al. Peel of araticum fruit (Annona crassiflora Mart.) as a source of antioxidant compounds with α-amylase, α-glucosidase and glycation inhibitory activities. Bioorg Chem  2016; 69: 167-82.
[http://dx.doi.org/10.1016/j.bioorg.2016.11.001] [PMID:  27842248] 
[31] 
Oliveira CC, Veloso CC, Ferreira RCM, et al. Peltatoside Isolated from Annona crassiflora Induces Periph-eral Antinociception by Activation of the Cannabinoid Sys-tem Planta Med  2017; 83(03/04): 261-7.
[32] 
Schiassi MCEV, Souza VR, Lago AMT, Campos LG, Queiroz F. Fruits from the Brazilian Cerrado region: Physico-chemical characterization, bioactive compounds, antioxidant activities, and sensory evaluation. Food Chem  2018; 245: 305-11.
[http://dx.doi.org/10.1016/j.foodchem.2017.10.104] [PMID:  29287376] 
[33] 
Roesler R. Effect of extracts from araticum (Annona crassiflora) on CCl4-induced liver damage in rats. Food Sci Technol (Campinas)  2011; 31(1): 93-100.
[http://dx.doi.org/10.1590/S0101-20612011000100012] 
[34] 
Massarolli A, Pereira MJB, Foerster LA. Annona crassiflora Mart. (Annonaceae): effect of crude extract of seeds on larvae of soybean looper Chrysodeixis includens (Lepidoptera: Noctuidae). Bragantia  2017; 76(3): 398-405.
[http://dx.doi.org/10.1590/1678-4499.374] 
[35] 
Krinski D, Massaroli A. Nymphicidal effect of vegetal extracts of Annona mucosa and Annona crassiflora (Magnoliales, Annonaceae) against rice stalk stink bug, Tibraca limbativentris (Hemiptera, Pentatomidae). Rev Bras Frutic  2014; 36: 217-24.
[http://dx.doi.org/10.1590/S0100-29452014000500026] 
[36] 
Silva JJ, Cerdeira CD, Chavasco JM, et al. In vitro screening antibacterial activity of Bidens pilosa Linné and Annona crassiflora Mart. against oxacillin resistant Staphylococcus aureus (ORSA) from the aerial environment at the dental clinic. Rev Inst Med Trop São Paulo  2014; 56(4): 333-40.
[http://dx.doi.org/10.1590/S0036-46652014000400011] [PMID:  25076435] 
[37] 
Turchen LM, Golin V, Butnariu AR, Pereira MJB. Selectivity of Annona (Annonaceae) extract on egg parasitoid Trissolcus urichi (Hymenoptera: Platygastridae). Rev Colomb Entomol  2014; 40(2): 176-80.
[38] 
Moura FBRM, Justino AB, Ferreira BA, Espindola FS, Araújo FA, Tomiosso TC. Potencial Pró-Fibrogênico e Antiinflamatório de uma Fração Enriquecida por Polifenol de Annona crassiflora em Reparo de Pele. Planta Med  2019; 85(07): 570-7.
[PMID:  30235473] 
[39] 
Silva VAO, Alves ALV, Rosa MN, et al. Separação de hexano de Annona crassiflora Mart. promove citotoxicidade e apoptose em linhas celulares de cancro do colo do útero humano. Invest New Drugs  2018; 37: 1-14.
[40] 
Roesler R, Lorencini M, Pastore G. Brazilian cerrado antioxidant sources: cytotoxicity and phototoxicity in vitro - Fontes de antioxidantes do cerrado brasileiro: citotoxicidade e fototoxicidade in vitro. Food Sci Technol (Campinas)  2010; 30(3): 814-21.
[http://dx.doi.org/10.1590/S0101-20612010000300038] 
[41] 
Ferraz CR, Silva DB, Prado LCDS, Canabrava HAN, Bispo-da-Silva LB. Antidiarrhoeic effect and dereplication of the aqueous extract of Annona crassiflora (Annonaceae). Nat Prod Res  2019; 33(4): 1-5.
[PMID:  29115144] 
[42] 
Rocha RS, Kassuya CAL, Formagio ASN, et al. Analysis of the anti-inflammatory and chemopreventive potential and description of the antimutagenic mode of action of the Annona crassiflora methanolic extract. Pharm Biol  2016; 54(1): 35-47.
[http://dx.doi.org/10.3109/13880209.2015.1014567] [PMID:  25885939] 
[43] 
Machado AR, Ferreira SR, da Silva Medeiros F, Fujiwara RT, de Souza Filho JD, Pimenta LP. Nematicidal activity of Annona crassiflora leaf extract on Caenorhabditis elegans. Parasit Vectors  2015; 8(113): 113.
[http://dx.doi.org/10.1186/s13071-015-0708-6] [PMID:  25885032] 
[44] 
Pimenta LPS, Garcia GM, Gonçalves SGV, Dionísio BL, Braga EM, Mosqueira VCF. In vivo antimalarial efficacy of acetogenins, alkaloids and flavonoids enriched fractions from Annona crassiflora Mart. Nat Prod Res  2014; 28(16): 1254-9.
[http://dx.doi.org/10.1080/14786419.2014.900496] [PMID:  24678811] 
[45] 
Cartaxo SL, Souza MMA, de Albuquerque UP. Medicinal plants with bioprospecting potential used in semi-arid northeastern Brazil. J Ethnopharmacol  2010; 131(2): 326-42.
[http://dx.doi.org/10.1016/j.jep.2010.07.003] [PMID:  20621178] 
[46] 
Mahmoud TS, Marques MR, Pessoa CO, et al. In vitro cytotoxic activity of Brazilian Middle West plant extracts. Rev Bras Farmacogn  2011; 21(3): 456-64.
[http://dx.doi.org/10.1590/S0102-695X2011005000061] 
[47] 
Formagio ASN, Kassuya CAL, Neto FF, et al. The flavonoid content and antiproliferative, hypoglycaemic, anti-inflammatory and free radical scavenging activities of Annona dioica St. Hill. BMC Complement Altern Med  2013; 13(1): 14.
[http://dx.doi.org/10.1186/1472-6882-13-14] [PMID:  23311341] 
[48] 
Bolson M, Hefler SM, Dall’Oglio Chaves EI, Gasparotto Junior A, Cardozo Junior EL. Ethno-medicinal study of plants used for treatment of human ailments, with residents of the surrounding region of forest fragments of Paraná, Brazil. J Ethnopharmacol  2015; 161: 1-10.
[http://dx.doi.org/10.1016/j.jep.2014.11.045] [PMID:  25482361] 
[49] 
Catarino L, Havik PJ, Romeiras MM. Medicinal plants of Guinea-Bissau: Therapeutic applications, ethnic diversity and knowledge transfer. J Ethnopharmacol  2016; 183: 71-94.
[http://dx.doi.org/10.1016/j.jep.2016.02.032] [PMID:  26923540] 
[50] 
Galvão SSL, Monteiro AS, Siqueira EP, et al. Annona glabra Flavonoids Act As Antimicrobials by Binding to Pseudomonas aeruginosa Cell Walls. Front Microbiol  2016; 7: 2053.
[http://dx.doi.org/10.3389/fmicb.2016.02053] [PMID:  28066374] 
[51] 
Liu Y, Liu D, Wan W, Zhang H. In vitro mitochondria-mediated anticancer and antiproliferative effects of Annona glabra leaf extract against human leukemia cells. J Photochem Photobiol B  2018; 189: 29-35.
[http://dx.doi.org/10.1016/j.jphotobiol.2018.07.026] [PMID:  30278342] 
[52] 
Ma H, Han J, Dong Q. Neuroprotective effect of Annona glabra extract against ethanol-induced apoptotic neurodegeneration in neonatal rats. J Photochem Photobiol B  2018; 181: 106-14.
[http://dx.doi.org/10.1016/j.jphotobiol.2018.02.022] [PMID:  29549803] 
[53] 
Rocha GS, Matsumoto RS, Lombardi AT, Lima MIS. Potential effects of fungicide and algaecide extracts of Annona glabra L. (Annonaceae) on the microalgae Raphidocelis subcapitata and on the oomycete Pythium. An Acad Bras Cienc  2017; 89(3)(Suppl.): 2101-11.
[http://dx.doi.org/10.1590/0001-3765201720160040] [PMID:  29166533] 
[54] 
Barnabé M, Saraceni CHC, Dutra-Correa M, Suffredini IB. The influence of Brazilian plant extracts on Streptococcus mutans biofilm. J Appl Oral Sci  2014; 22(5): 366-72.
[http://dx.doi.org/10.1590/1678-775720140085] [PMID:  25466471] 
[55] 
Brito MT, Ferreira RC, Beltrão DM, et al. Antitumor activity and toxicity of volatile oil from the leaves of Annona leptopetala. Rev Bras Farmacogn  2018; 28: 602-9.
[http://dx.doi.org/10.1016/j.bjp.2018.06.009] 
[56] 
Cauich CAC, Duch ES, Ancona DB, et al. Tropical fruit peel powders as functional ingredients: Evaluation of their bioactive compounds and antioxidant activity. J Funct Foods  2017; 37: 501-6.
[http://dx.doi.org/10.1016/j.jff.2017.08.028] 
[57] 
Moo-Huchin VM, Estrada-Mota I, Estrada-León R, et al. Determination of some physicochemical characteristics, bioactive compounds and antioxidant activity of tropical fruits from Yucatan, Mexico. Food Chem  2014; 152: 508-15.
[http://dx.doi.org/10.1016/j.foodchem.2013.12.013] [PMID:  24444968] 
[58] 
Loaeza APJ, Sanchez NFS, Blanco RV, Guzman BSS. Raul Salas-Coronado. Chemical composition, color, and antioxidant activity of three varieties of Annona diversifolia Safford fruits. Ind Crops Prod  2011; 34: 1262-8.
[http://dx.doi.org/10.1016/j.indcrop.2010.06.012] 
[59] 
Carballo AI, Martínez AL, González-Trujano ME, et al. Antinociceptive activity of Annona diversifolia Saff. leaf extracts and palmitone as a bioactive compound. Pharmacol Biochem Behav  2010; 95(1): 6-12.
[http://dx.doi.org/10.1016/j.pbb.2009.11.017] [PMID:  19969018] 
[60] 
Brindis F, González-Trujano ME, González-Andrade M, Aguirre-Hernández E, Villalobos-Molina R. Aqueous extract of Annona macroprophyllata: a potential α-glucosidase inhibitor. BioMed Res Int 2013.2013591313
[http://dx.doi.org/10.1155/2013/591313] [PMID:  24298552] 
[61] 
Pagani E, Santos JFL, Rodrigues E. Culture-Bound Syndromes of a Brazilian Amazon Riverine population: Tentative correspondence between traditional and conventional medicine terms and possible ethnopharmacological implications. J Ethnopharmacol  2017; 203: 80-9.
[http://dx.doi.org/10.1016/j.jep.2017.03.024] [PMID:  28344031] 
[62] 
Ribeiro LP, Akhtar Y, Vendramim JD, Isman MB. Comparative bioactivity of selected seed extracts from Brazilian Annona species and an acetogenin-based commercial bioinsecticide against Trichoplusia ni and Myzus persicae. Crop Prot  2014; 62: 100-6.
[http://dx.doi.org/10.1016/j.cropro.2014.04.013] 
[63] 
Pavan V, Sancho RAS, Pastore GM. The effect of in vitro digestion on the antioxidant activity of fruit extracts (Carica papaya, Artocarpus heterophillus and Annona marcgravii) LWT - Food Sci Techno 2014.59-1251.1247-51. 
[64] 
Tauchen J, Bortl L, Huml L, et al. Phenolic composition, antioxidant and anti-proliferative activities of edible and medicinal plants from the Peruvian Amazon. Rev Bras Farmacogn  2016; 26: 728-37.
[http://dx.doi.org/10.1016/j.bjp.2016.03.016] 
[65] 
Barbalho SM, Soares de Souza Mda S, dos Santos Bueno PC, et al. Annona montana fruit and leaves improve the glycemic and lipid profiles of Wistar rats. J Med Food  2012; 15(10): 917-22.
[http://dx.doi.org/10.1089/jmf.2012.0088] [PMID:  22856324] 
[66] 
Clement YN, Mahase V, Jagroop A, et al. Herbal remedies and functional foods used by cancer patients attending specialty oncology clinics in Trinidad. BMC Complement Altern Med  2016; 16(1): 399.
[http://dx.doi.org/10.1186/s12906-016-1380-x] [PMID:  27769229] 
[67] 
Segun PA, Ogbole OO, Ajaiyeoba EO. Medicinal plants used in the management of cancer among the ijebus ofsouthwestern Nigeria. J Herb Med  2018; 14: 68-75.
[http://dx.doi.org/10.1016/j.hermed.2018.04.002] 
[68] 
Jaradat NA, Shawahna R, Eid AM, Al-Ramahi R, Asma MK, Zaid AN. Herbal remedies use by breast cancer patients in the West Bank of Palestine. J Ethnopharmacol  2016; 178: 1-8.
[http://dx.doi.org/10.1016/j.jep.2015.11.050] [PMID:  26656536] 
[69] 
Bieski IGC, Leonti M, Arnason JT, et al. Ethnobotanical study of medicinal plants by population of Valley of Juruena Region, Legal Amazon, Mato Grosso, Brazil. J Ethnopharmacol  2015; 173: 383-423.
[http://dx.doi.org/10.1016/j.jep.2015.07.025] [PMID:  26234177] 
[70] 
Monigatti M, Bussmann RW, Weckerle CS. Medicinal plant use in two Andean communities located at different altitudes in the Bolívar Province, Peru. J Ethnopharmacol  2013; 145(2): 450-64.
[http://dx.doi.org/10.1016/j.jep.2012.10.066] [PMID:  23159468] 
[71] 
Samoisy AK, Mahomoodally MF. Ethnopharmacological analysis of medicinal plants used against non-communicable diseases in Rodrigues Island, Indian Ocean. J Ethnopharmacol  2015; 173: 20-38.
[http://dx.doi.org/10.1016/j.jep.2015.06.036] [PMID:  26133061] 
[72] 
Ong HG, Kim YD. Quantitative ethnobotanical study of the medicinal plants used by the Ati Negrito indigenous group in Guimaras island, Philippines. J Ethnopharmacol  2014; 157: 228-42.
[http://dx.doi.org/10.1016/j.jep.2014.09.015] [PMID:  25240586] 
[73] 
Sreekeesoon DP, Mahomoodally MF. Ethnopharmacological analysis of medicinal plants and animals used in the treatment and management of pain in Mauritius. J Ethnopharmacol  2014; 157: 181-200.
[http://dx.doi.org/10.1016/j.jep.2014.09.030] [PMID:  25261690] 
[74] 
Abdillah S, Tambunan RM, Sinaga YM, Farida Y. Ethno-botanical survey of plants used in the traditional treatment of malaria in Sei Kepayang, Asahan of North Sumatera. (Asian Pac J Trop Med )2014; 7S1: S104-7.
[http://dx.doi.org/10.1016/S1995-7645(14)60213-3] [PMID: 25312101] 
[75] 
Tsabang N, Fokou PVT, Tchokouaha LRY, et al. Ethnopharmacological survey of Annonaceae medicinal plants used to treat malaria in four areas of Cameroon. J Ethnopharmacol  2012; 139(1): 171-80.
[http://dx.doi.org/10.1016/j.jep.2011.10.035] [PMID:  22079831] 
[76] 
Ritter RA, Monteiro MVB, Monteiro FOB, et al. Ethnoveterinary knowledge and practices at Colares Island, Pará state, eastern Amazon, Brazil. J Ethnopharmacol  2012; 144(2): 346-52.
[http://dx.doi.org/10.1016/j.jep.2012.09.018] [PMID:  23000170] 
[77] 
Odoh UE, Uzor PF, Eze CL, Akunne TC, Onyegbulam CM, Osadebe PO. Medicinal plants used by the people of Nsukka Local Government Area, south-eastern Nigeria for the treatment of malaria: An ethnobotanical survey. J Ethnopharmacol  2018; 218: 1-15.
[http://dx.doi.org/10.1016/j.jep.2018.02.034] [PMID:  29477369] 
[78] 
Neamsuvan O, Komonhiran P, Boonming K. Medicinal plants used for hypertension treatment by folk healers in Songkhla province, Thailand. J Ethnopharmacol  2018; 214: 58-70.
[http://dx.doi.org/10.1016/j.jep.2017.11.032] [PMID:  29229570] 
[79] 
Van’t Klooster C, van Andel T, Reis R. Patterns in medicinal plant knowledge and use in a Maroon village in Suriname. J Ethnopharmacol  2016; 189: 319-30.
[http://dx.doi.org/10.1016/j.jep.2016.05.048] [PMID:  27215681] 
[80] 
Kantati YT, Kodjo KM, Dogbeavou KS, Vaudry D, Leprince J, Gbeassor M. Ethnopharmacological survey of plant species used in folk medicine against central nervous system disorders in Togo. J Ethnopharmacol  2016; 181: 214-20.
[http://dx.doi.org/10.1016/j.jep.2016.02.006] [PMID:  26869544] 
[81] 
Asase A, Yohonu DT. Ethnobotanical study of herbal medicines for management of diabetes mellitus in Dangme West District of southern Ghana. J Herb Med  2016; 6: 204-9.
[http://dx.doi.org/10.1016/j.hermed.2016.07.002] 
[82] 
Kpodar MS, Evi PL, Bakoma B, et al. Ethnopharmacological survey of plants used in the treatment of diabetes mellitus in south of Togo (Maritime Region). J Herb Med  2015; 5: 147-52.
[http://dx.doi.org/10.1016/j.hermed.2015.06.002] 
[83] 
de Santana BF, Voeks RA, Funch LS. Ethnomedicinal survey of a maroon community in Brazil’s Atlantic tropical forest. J Ethnopharmacol  2016; 181: 37-49.
[http://dx.doi.org/10.1016/j.jep.2016.01.014] [PMID:  26802786] 
[84] 
Hajdu Z, Hohmann J. An ethnopharmacological survey of the traditional medicine utilized in the community of Porvenir, Bajo Paraguá Indian Reservation, Bolivia. J Ethnopharmacol  2012; 139(3): 838-57.
[http://dx.doi.org/10.1016/j.jep.2011.12.029] [PMID:  22222280] 
[85] 
Kpodar MS, Karou SD, Katawa G, et al. An ethnobotanical study of plants used to treat liver diseases in the Maritime region of Togo. J Ethnopharmacol  2016; 181: 263-73.
[http://dx.doi.org/10.1016/j.jep.2015.12.051] [PMID:  26732630] 
[86] 
Soelberg J, Davis O, Jäger AK. Historical versus contemporary medicinal plant uses in the US Virgin Islands. J Ethnopharmacol  2016; 192: 74-89.
[http://dx.doi.org/10.1016/j.jep.2016.07.005] [PMID:  27377341] 
[87] 
Picking D, Delgoda R, Younger N, Germosén-Robineau L, Boulogne I, Mitchell S. TRAMIL ethnomedicinal survey in Jamaica. J Ethnopharmacol  2015; 169: 314-27.
[http://dx.doi.org/10.1016/j.jep.2015.04.027] [PMID:  25929450] 
[88] 
Girardi C, Butaud JF, Ollier C, et al. Herbal medicine in the Marquesas Islands. J Ethnopharmacol  2015; 161: 200-13.
[http://dx.doi.org/10.1016/j.jep.2014.09.045] [PMID:  25527315] 
[89] 
Chander MP, Kartick C, Gangadhar J, Vijayachari P. Ethno medicine and healthcare practices among Nicobarese of Car Nicobar - an indigenous tribe of Andaman and Nicobar Islands. J Ethnopharmacol  2014; 158(Pt A): 18-24.
[http://dx.doi.org/10.1016/j.jep.2014.09.046] [PMID: 25305516] 
[90] 
Neiva VA, Ribeiro MNS, Nascimento FRF, Cartágenes MSS, Moraes DFC, Amaral FMM. Plant species used in giardiasis treatment: ethnopharmacology and in vitro evaluation of anti-Giardia activity. Rev Bras Farmacogn  2014; 24: 215-24.
[http://dx.doi.org/10.1016/j.bjp.2014.04.004] 
[91] 
Chintamunnee V, Mahomoodally MF. Herbal medicine commonly used against non-communicable diseases in the tropical island of Mauritius. J Herb Med  2012; 2: 113-25.
[http://dx.doi.org/10.1016/j.hermed.2012.06.001] 
[92] 
Boulogne I, Germosén-Robineau L, Ozier-Lafontaine H, Fleury M, Loranger-Merciris G. TRAMIL ethnopharmalogical survey in Les Saintes (Guadeloupe, French West Indies): a comparative study. J Ethnopharmacol  2011; 133(3): 1039-50.
[http://dx.doi.org/10.1016/j.jep.2010.11.034] [PMID:  21094238] 
[93] 
Bradacs G, Heilmann J, Weckerle CS. Medicinal plant use in Vanuatu: a comparative ethnobotanical study of three islands. J Ethnopharmacol  2011; 137(1): 434-48.
[http://dx.doi.org/10.1016/j.jep.2011.05.050] [PMID:  21679762] 
[94] 
Vandebroek I, Balick MJ, Ososki A, et al. The importance of botellas and other plant mixtures in Dominican traditional medicine. J Ethnopharmacol  2010; 128(1): 20-41.
[http://dx.doi.org/10.1016/j.jep.2009.12.013] [PMID:  20006697] 
[95] 
Bussmann RW, Malca-García G, Glenn A, et al. Minimum inhibitory concentrations of medicinal plants used in Northern Peru as antibacterial remedies. J Ethnopharmacol  2010; 132(1): 101-8.
[http://dx.doi.org/10.1016/j.jep.2010.07.048] [PMID:  20678568] 
[96] 
Zorofchian Moghadamtousi S, Karimian H, Rouhollahi E, Paydar M, Fadaeinasab M, Abdul Kadir H. Annona muricata leaves induce G1 cell cycle arrest and apoptosis through mitochondria-mediated pathway in human HCT-116 and HT-29 colon cancer cells. J Ethnopharmacol  2014; 156: 277-89.
[http://dx.doi.org/10.1016/j.jep.2014.08.011] [PMID:  25195082] 
[97] 
Mancini S, Nardo L, Gregori M, et al. Functionalized liposomes and phytosomes loading Annona muricata L. aqueous extract: Potential nanoshuttles for brain-delivery of phenolic compounds. Phytomedicine  2018; 42: 233-44.
[http://dx.doi.org/10.1016/j.phymed.2018.03.053] [PMID:  29655691] 
[98] 
Gavamukulya Y, Abou-Elella F, Wamunyokoli F. , AEl-Shemy H. Phytochemical screening, anti-oxidant activity and in vitro anticancer potential of ethanolic and water leaves extracts of Annona muricata (Graviola). Asian Pac J Trop Med  2014; 7S1: S355-63.
[http://dx.doi.org/10.1016/S1995-7645(14)60258-3] [PMID:  25312150] 
[99] 
Neta MTS, Jesus MS, Silva JLA, et al. Effect of spray drying on bioactive and volatile compounds in soursop (Annona muricata) fruit pulp. Food Res Int  2019; 124: 70-7.
[http://dx.doi.org/10.1016/j.foodres.2018.09.039] [PMID:  31466652] 
[100] 
Moraes IVM, Rabelo RS, Pereira JAL, Hubinger MD, Schmidt FL. Concentration of hydroalcoholic extracts of graviola (Annona muricata L.) pruning waste by ultra and nanofiltration: Recovery of bioactive compounds and prediction of energy consumption. J Clean Prod  2017; 174: 1412-21.
[http://dx.doi.org/10.1016/j.jclepro.2017.11.062] 
[101] 
Ravaomanarivo LHRR, Razafindraleva HA, Raharimalala FN, Rasoahantaveloniaina B, Ravelonandro PH, Mavingui P. Efficacy of seed extracts of Annona squamosa and Annona muricata (Annonaceae) for the control of Aedes albopictus and Culex quinquefasciatus (Culicidae). Asian Pac J Trop Biomed  2014; 4(10): 798-806.
[http://dx.doi.org/10.12980/APJTB.4.2014C1264] 
[102] 
Minari JB, Okeke U. Chemopreventive effect of Annona muricata on DMBA-induced cell proliferation in the breast tissues of female albino mice. Egypt J Med Hum Genet  2014; 15: 327-34.
[http://dx.doi.org/10.1016/j.ejmhg.2014.05.001] 
[103] 
Md Roduan MR, Hamid RA, Sulaiman H, Mohtarrudin N. Annona muricata leaves extracts prevent DMBA/TPA-induced skin tumorigenesis via modulating antioxidants enzymes system in ICR mice. Biomed Pharmacother  2017; 94: 481-8.
[http://dx.doi.org/10.1016/j.biopha.2017.07.133] [PMID:  28779710] 
[104] 
Nwokocha CR, Owu DU, Gordon A, et al. Possible mechanisms of action of the hypotensive effect of Annona muricata (soursop) in normotensive Sprague-Dawley rats. Pharm Biol  2012; 50(11): 1436-41.
[http://dx.doi.org/10.3109/13880209.2012.684690] [PMID:  22950673] 
[105] 
Souza VR, Pereira PAP, Queiroz F, Borges SV, Carneiro JDS. Determination of bioactive compounds, antioxidant activity and chemical composition of Cerrado Brazilian fruits. Food Chem  2012; 134: 381-6.
[http://dx.doi.org/10.1016/j.foodchem.2012.02.191] 
[106] 
Torres CDS, Santos FDS, Guiguer EL, et al. Efeito de Morinda citrifolia e Annona muricata em Células Tumorais Erhlich em Camundongos Albinos Suíços e Células de Fibroblastos In Vitro. J Med Food  2019; 22(1): 46-51.
[http://dx.doi.org/10.1089/jmf.2018.0061] [PMID:  30412453] 
[107] 
Chamcheu JC, Rady I, Chamcheu RN, et al. Graviola (Annona muricata) Exerts Anti-Proliferative, Anti-Clonogenic and Pro-Apoptotic Effects in Human Non-Melanoma Skin Cancer UW-BCC1 and A431 Cells In Vitro: Involvement of Hedgehog Signaling. Int J Mol Sci  2018; 19(6): 1-24.
[http://dx.doi.org/10.3390/ijms19061791] [PMID:  29914183] 
[108] 
Abdullah M, Syam AF, Meilany S, et al. The Value of Caspase-3 after the Application of Annona muricata Leaf Extract in COLO-205 Colorectal Cancer Cell Line. Gastroenterol Res Pract 2017.20174357165
[http://dx.doi.org/10.1155/2017/4357165] [PMID:  28487731] 
[109] 
Kuete V, Dzotam JK, Voukeng IK, Fankam AG, Efferth T. Cytotoxicity of methanol extracts of Annona muricata, Passiflora edulis and nine other Cameroonian medicinal plants towards multi-factorial drug-resistant cancer cell lines. Springerplus  2016; 5(1): 1666.
[http://dx.doi.org/10.1186/s40064-016-3361-4] [PMID:  27730025] 
[110] 
Liu N, Yang HL, Wang P, et al. Functional proteomic analysis revels that the ethanol extract of Annona muricata L. induces liver cancer cell apoptosis through endoplasmic reticulum stress pathway. J Ethnopharmacol  2016; 189: 210-7.
[http://dx.doi.org/10.1016/j.jep.2016.05.045] [PMID:  27224241] 
[111] 
Pieme CA, Kumar SG, Dongmo MS, et al. Antiproliferative activity and induction of apoptosis by Annona muricata (Annonaceae) extract on human cancer cells. BMC Complement Altern Med  2014; 14: 516.
[http://dx.doi.org/10.1186/1472-6882-14-516] [PMID:  25539720] 
[112] 
Asare GA, Afriyie D, Ngala RA, et al. Antiproliferative activity of aqueous leaf extract of Annona muricata L. on the prostate, BPH-1 cells, and some target genes. Integr Cancer Ther  2015; 14(1): 65-74.
[http://dx.doi.org/10.1177/1534735414550198] [PMID:  25411208] 
[113] 
Paul J, Gnanam R, Jayadeepa RM, Arul L. Atividade Anti-Câncer na Graviola, um Excitante Extrato de Plantas Medicinais vs Várias Linhas de Câncer de Câncer e um Estudo Computacional Detalhado sobre os Potentes Lâminas Anti-Cancerígenas. Curr Top Med Chem  2013; 13: 1666-73.
[http://dx.doi.org/10.2174/15680266113139990117] [PMID:  23889049] 
[114] 
Roduan MRM, Hamid RA, Kqueen CY, Mohtarrudin N. Cytotoxicity, antitumor-promoting and antioxidant activities of Annona muricata in vitro. J Herb Med  2019; 15: 1-25.
[115] 
Adaramoye OA, Oladipo TD, Akanni OO, Abiola OJ. Hexane fraction of Annona muricata (Sour sop) seed ameliorates testosterone-induced benign prostatic hyperplasia in rats. Biomed Pharmacother  2019; 111: 403-13.
[http://dx.doi.org/10.1016/j.biopha.2018.12.038] [PMID:  30594779] 
[116] 
Kim JY, Dao TTP, Song K, et al. Annona muricata Leaf Extract Triggered Intrinsic Apoptotic Pathway to Attenuate Cancerous Features of Triple Negative Breast Cancer MDA-MB-231 Cells. Evid.-. Based Complementary Altern Med  2018; 2018: 1-10.
[http://dx.doi.org/10.1155/2018/7972916] 
[117] 
Syed Najmuddin SU, Romli MF, Hamid M, Alitheen NB, Nik Abd Rahman NM. Anti-cancer effect of Annona Muricata Linn Leaves Crude Extract (AMCE) on breast cancer cell line. BMC Complement Altern Med  2016; 16(1): 311.
[http://dx.doi.org/10.1186/s12906-016-1290-y] [PMID:  27558166] 
[118] 
Souza DO, Dos Santos Sales V, de Souza Rodrigues CK, et al. Phytochemical Analysis and Central Effects of Annona Muricata Linnaeus: Possible Involvement of the Gabaergic and Monoaminergic Systems. Iran J Pharm Res  2018; 17(4): 1306-17.
[PMID:  30568689] 
[119] 
Quilez AM, Paz SM, Arche AF, Puerta RD, Gimenez MDG. Diets supplemented with Annona muricata improve the symptoms of fibromyalgia. PharmaNutrition  2018; 6: 81-4.
[http://dx.doi.org/10.1016/j.phanu.2018.04.001] 
[120] 
Bento EB, Júnior FEB, de Oliveira DR, et al. Antiulcerogenic activity of the hydroalcoholic extract of leaves of Annona muricata Linnaeus in mice. Saudi J Biol Sci  2018; 25(4): 609-21.
[http://dx.doi.org/10.1016/j.sjbs.2016.01.024] [PMID:  29736140] 
[121] 
Hamid RA, Foong CP, Ahmad Z, Hussain MK. Antinociceptive and anti-ulcerogenic activities of the ethanolic extract of Annona muricata leaf. Rev Bras Farmacogn  2012; 22(3): 630-41.
[http://dx.doi.org/10.1590/S0102-695X2012005000001] 
[122] 
de Sousa OV, Vieira GDV, de Jesus RG, de Pinho J, Yamamoto CH, Alves MS. Antinociceptive and anti-inflammatory activities of the ethanol extract of Annona muricata L. leaves in animal models. Int J Mol Sci  2010; 11(5): 2067-78.
[http://dx.doi.org/10.3390/ijms11052067] [PMID:  20559502] 
[123] 
Adefegha SA, Oyeleye SI, Oboh G. Distribution of Phenolic Contents, Antidiabetic Potentials, Antihypertensive Properties, and Antioxidative Effects of Soursop (Annona muricata L.) Fruit Parts In Vitro. Biochem Res Int 2015.2015347673
[http://dx.doi.org/10.1155/2015/347673] [PMID:  26788368] 
[124] 
Pinto LC, Lima ATC, Suzarth SS, et al. Anonna muricata L. (soursop) seed oil improves type 1 diabetes parameters in vivo and in vitro. PharmaNutrition  2018; 6: 1-8.
[http://dx.doi.org/10.1016/j.phanu.2017.11.002] 
[125] 
Franco RR, Carvalho DS, Moura FBR, et al. Evaluation of α-amylase, α-glucosidase and lipase inhibitory activities of some medicinal plants used in type-2 Diabetes Mellitus and its anti-glycation and antioxidant roles. J Ethnopharmacol  2017; 215: 140-6.
[http://dx.doi.org/10.1016/j.jep.2017.12.032] [PMID:  29274842] 
[126] 
Womeni HM, Tonfack Djikeng F, Iruku NSSP, Karuna MSL, Prasad RB, Linder M. Valorization of soursop flowers (Annona muricata L.) as potent source of natural antioxidants for stabilization of palm olein during accelerated storage. Food Sci Nutr  2016; 4(6): 802-10.
[http://dx.doi.org/10.1002/fsn3.349] [PMID:  27826429] 
[127] 
Moe TS, Win HH, Hlaing TT, Lwin WW, Htet ZM, Mya KM. Evaluation of in vitro antioxidant, antiglycation and antimicrobial potential of indigenous Myanmar medicinal plants. J Integr Med  2018; 16(5): 358-66.
[http://dx.doi.org/10.1016/j.joim.2018.08.001] [PMID:  30120077] 
[128] 
Silva KDRR, Sirasa MSF. Antioxidant properties of selected fruit cultivars grown in Sri Lanka. Food Chem  2018; 238: 203-8.
[http://dx.doi.org/10.1016/j.foodchem.2016.08.102] [PMID:  28867094] 
[129] 
Oboh G, Ademosun AO, Akinleye M, Omojokun OS, Boligon AA, Athayde ML. Starch composition, glycemic indices, phenolic constituents, and antioxidative and antidiabetic properties of some common tropical fruits. J Ethn Foods  2015; 2: 64-73.
[http://dx.doi.org/10.1016/j.jef.2015.05.003] 
[130] 
Waisundara VY, Watawana MI. The classification of sri lankan medicinal herbs: an extensive comparison of the antioxidant activities. J Tradit Complement Med  2014; 4(3): 196-202.
[http://dx.doi.org/10.4103/2225-4110.126175] [PMID:  25161925] 
[131] 
Port’s OS, Chisté RC, Godoy HT, Prado MA. The phenolic compounds and the antioxidant potential of infusion of herbs from the Brazilian Amazonian region. Food Res Int  2013; 53: 875-81.
[http://dx.doi.org/10.1016/j.foodres.2013.02.010] 
[132] 
Almeida MMB, Sousa PHM, Arriaga AMC, et al. Bioactive compounds and antioxidant activity of fresh exotic fruits from northeastern Brazil. Food Res Int  2011; 44: 2155-9.
[http://dx.doi.org/10.1016/j.foodres.2011.03.051] 
[133] 
Sousa MSB, Vieira LM, Lima A. Fenólicos totais e capacidade antioxidante in vitro de resíduos de polpas de frutas tropicais. Braz J Food Technol  2011; 14(3): 202-10.
[http://dx.doi.org/10.4260/BJFT2011140300024] 
[134] 
Jimoh OA, Ayedun ES, Oyelade WA, et al. Protective effect of soursop (Annona muricata linn.) juice on oxidative stress in heat stressed rabbits. J Anim Sci Technol  2018; 60(28): 28.
[http://dx.doi.org/10.1186/s40781-018-0186-4] [PMID:  30473869] 
[135] 
Son YR, Choi EH, Kim GT, Park TS, Shim SM. Bioefficacy of Graviola leaf extracts in scavenging free radicals and upregulating antioxidant genes. Food Funct  2016; 7(2): 861-71.
[http://dx.doi.org/10.1039/C5FO01258A] [PMID:  26674326] 
[136] 
Agu KC, Okolie PN. Proximate composition, phytochemical analysis, and in vitro antioxidant potentials of extracts of Annona muricata (Soursop). Food Sci Nutr  2017; 5(5): 1029-36.
[http://dx.doi.org/10.1002/fsn3.498] [PMID:  28948021] 
[137] 
Isabelle M, Lee BL, Lim MT, Koh WP, Huang D, Nam Ong CN. Antioxidant activity and profiles of common fruits in Singapore. Food Chem  2010; 123: 77-84.
[http://dx.doi.org/10.1016/j.foodchem.2010.04.002] 
[138] 
Dawood HM, Ibrahim RS, Shawky E, Hammoda HMA, Metwally AM. Integrated in silico-in vitro strategy for screening of some traditional Egyptian plants for human aromatase inhibitors. J Ethnopharmacol  2018; 224: 359-72.
[http://dx.doi.org/10.1016/j.jep.2018.06.009] [PMID:  29909120] 
[139] 
Pinto NCC, Campos LM, Evangelista ACS, et al. Antimicrobial Annona muricata L. (soursop) extract targets the cell membranes of Gram-positive and Gram-negative bacteria. Ind Crops Prod  2017; 107: 332-40.
[http://dx.doi.org/10.1016/j.indcrop.2017.05.054] 
[140] 
Dzotam JK, Touani FK, Kuete V. Antibacterial activities of the methanol extracts of Canarium schweinfurthii and four other Cameroonian dietary plants against multi-drug resistant Gram-negative bacteria. Saudi J Biol Sci  2016; 23(5): 565-70.
[http://dx.doi.org/10.1016/j.sjbs.2015.06.006] [PMID:  27579004] 
[141] 
Pai BM, Rajesh G, Shenoy R, Rao A. Anti-microbial Efficacy of Soursop Leaf Extract (Annona muricata) on Oral Pathogens: An In-vitro Study. J Clin Diagn Res  2016; 10(11): ZC01-4.
[http://dx.doi.org/10.7860/JCDR/2016/18329.8762] [PMID:  28050493] 
[142] 
Mathew J, George R, Theruvil R, Padavil TC, Tomy L, Kurian A. Antibacterial Activity of Leaf Extract of Annona muricata and Simarouba glauca on Enterococcus faecalis. J Contemp Dent Pract  2016; 17(8): 650-3.
[http://dx.doi.org/10.5005/jp-journals-10024-1906] [PMID:  27659082] 
[143] 
Bustos AVG, Jiménez MG, Mora RMS. The Annona muricata leaf ethanol extract affects mobility and reproduction in mutant strain NB327 Caenorhabditis elegans. Biochem Biophys Rep  2017; 10: 282-6.
[http://dx.doi.org/10.1016/j.bbrep.2017.04.016] [PMID:  28955756] 
[144] 
Moghadamtousi SZ, Rouhollahi E, Hajrezaie M, Karimian H, Abdulla MA, Kadir HA. Annona muricata leaves accelerate wound healing in rats via involvement of Hsp70 and antioxidant defence. Int J Surg  2015; 18: 110-7.
[http://dx.doi.org/10.1016/j.ijsu.2015.03.026] [PMID:  25899210] 
[145] 
Harun NH, Septama AW, Jantan I. Immunomodulatory effects of selected Malaysian plants on the CD18/11a expression and phagocytosis activities of leukocytes. Asian Pac J Trop Biomed  2015; 5(1): 48-53.
[http://dx.doi.org/10.1016/S2221-1691(15)30170-2] 
[146] 
Kannan RR, Vincent SGP. Screening of herbal extracts influencing hematopoiesis and their chemical genetic effects in embryonic zebrafish. Asian Pac J Trop Biomed  2012; 2(2): S1002-9.
[http://dx.doi.org/10.1016/S2221-1691(12)60351-7] 
[147] 
Kim GT, Tran NKS, Choi EH, et al. Immunomodulatory Efficacy of Standardized Annona muricata (Graviola) Leaf Extract via Activation of Mitogen-Activated Protein Kinase Pathways in RAW 264.7 Macrophages. Evid Based Complement Alternat Med 2016.20162905127
[http://dx.doi.org/10.1155/2016/2905127] [PMID:  28096884] 
[148] 
Villegas RG, Dávila MF, Rodríguez EG, et al. Efecto insecticida de extractos vegetales, sobre larvas de Culex tarsalis (Diptera: Culicidae) en laboratório. Rev Mex Cienc Agric  2013; 4(2): 273-84.
[http://dx.doi.org/10.29312/remexca.v4i2.1237] 
[149] 
Barrera AS, García CM, Henao GJP. Actividad insecticida de extractos vegetales sobre larvas de Aedes aegypti, Diptera: Culicidae. Rev CES Med  2013; 27(2): 193-203.
[150] 
Grzybowski A, Tiboni M, Silva MAN, Chitolina RF, Passos M, Fontana JD. The combined action of phytolarvicides for the control of dengue fever vector, Aedes aegypti. Rev Bras Farmacogn  2012; 22(3): 549-57.
[http://dx.doi.org/10.1590/S0102-695X2012005000026] 
[151] 
Ferreira LE, Castro PMN, Chagas ACS, França SC, Beleboni RO. In vitro anthelmintic activity of aqueous leaf extract of Annona muricata L. (Annonaceae) against Haemonchus contortus from sheep. Exp Parasitol  2013; 134(3): 327-32.
[http://dx.doi.org/10.1016/j.exppara.2013.03.032] [PMID:  23583362] 
[152] 
Boyom FF, Fokou PVT, Yamthe LRT, et al. Potent antiplasmodial extracts from Cameroonian Annonaceae. J Ethnopharmacol  2011; 134(3): 717-24.
[http://dx.doi.org/10.1016/j.jep.2011.01.020] [PMID:  21256952] 
[153] 
Leesombun A, Boonmasawai S, Nishikawa Y. Ethanol Extracts from Thai Plants have Anti-Plasmodium and Anti-Toxoplasma Activities In Vitro. Acta Parasitol  2019; 64(2): 257-61.
[http://dx.doi.org/10.2478/s11686-019-00036-w] [PMID:  30820881] 
[154] 
Yamthe LRT, Fokou PVT, Mbouna CDJ, et al. Extracts from Annona Muricata L. and Annona Reticulata L. (Annonaceae) Potently and Selectively Inhibit Plasmodium Falciparum. Medicines (Basel)  2015; 2(2): 55-66.
[http://dx.doi.org/10.3390/medicines2020055] [PMID:  28930201] 
[155] 
Somsak V, Polwiang N, Chachiyo S. In Vivo Antimalarial Activity of Annona muricata Leaf Extract in Mice Infected with Plasmodium berghei. J Pathogens 2016.20163264070
[http://dx.doi.org/10.1155/2016/3264070] [PMID:  27092277] 
[156] 
Cremonez CM, Leite FP, Bordon Kde C, et al. Experimental Lachesis muta rhombeata envenomation and effects of soursop (Annona muricata) as natural antivenom. J Venom Anim Toxins Incl Trop Dis  2016; 22(1): 12.
[http://dx.doi.org/10.1186/s40409-016-0067-6] [PMID:  26957955] 
[157] 
Gomes IB, Trindade RCP, Sant’Ana AEG, Lemos EEP, Júnior IDB. Bioactivity of microencapsulated soursop seeds extract on Plutella xylostella. Cienc Rural  2016; 46(5): 771-5.
[http://dx.doi.org/10.1590/0103-8478cr20141701] 
[158] 
Foong CP, Hamid RA. Evaluation of anti-infl ammatory activities of ethanolic extract of Annona muricata leaves. Rev Bras Farmacogn  2012; 22(6): 1301-7.
[http://dx.doi.org/10.1590/S0102-695X2012005000096] 
[159] 
Trindade RCP, Luna JS, Lima MRF, Silva PP, Sant’ana AEG. Larvicidal activity and seasonal variation of Annona muricata (Annonaceae) extract on Plutella xylostella (Lepidoptera: Plutellidae). Rev Colomb Entomol  2011; 37(2): 223-7.
[160] 
Arroyo-Acevedo J, Franco-Quino C, Ruiz-Ramirez E, et al. Antiallergic effect of the atomized extract of rhizome of Curcuma longa, flowers of Cordia lutea and leaves of Annona muricata. Ther Clin Risk Manag  2016; 12: 1643-7.
[http://dx.doi.org/10.2147/TCRM.S115786] [PMID:  27877047] 
[161] 
Kffuri CW, Lopes MA, Ming LC, Odonne G, Kinupp VF. Antimalarial plants used by indigenous people of the Upper Rio Negro in Amazonas, Brazil. J Ethnopharmacol  2016; 178: 188-98.
[http://dx.doi.org/10.1016/j.jep.2015.11.048] [PMID:  26656535] 
[162] 
Ribeiro LP, Vendramim JD, Bicalho KU, et al. Annona mucosa Jacq. (Annonaceae): A promising source of bioactive compounds against Sitophilus zeamais Mots. (Coleoptera: Curculionidae). J Stored Prod Res  2013; 55: 6-14.
[http://dx.doi.org/10.1016/j.jspr.2013.06.001] 
[163] 
Barboza TJS, Ferreira AF, Ignacio ACPR, Albarello N. Antimicrobial activity of Anonna mucosa (Jacq.) grown in vivo and obtained by in vitroculture. Braz J Microbiol  2015; 46(3): 785-9.
[http://dx.doi.org/10.1590/S1517-838246320140468] [PMID:  26413061] 
[164] 
Bernardi D, Ribeiro L, Andreazza F, et al. Potential use of Annona by products to control Drosophila suzukii and toxicity to its parasitoid Trichopria anastrephae. Ind Crops Prod  2017; 110: 30-5.
[http://dx.doi.org/10.1016/j.indcrop.2017.09.004] 
[165] 
Costa EV, Dutra LM, Salvador MJ, Ribeiro LHG, Gadelha FR, de Carvalho JE. Chemical composition of the essential oils of Annona pickelii and Annona salzmannii (Annonaceae), and their antitumour and trypanocidal activities. Nat Prod Res  2013; 27(11): 997-1001.
[http://dx.doi.org/10.1080/14786419.2012.686913] [PMID:  22583044] 
[166] 
De-la-Cruz-Chacón I, Riley-Saldaña CA, Arrollo-Gómez S, Sancristóbal-Domínguez TJ, Castro-Moreno M, González-Esquinca AR. Spatio-Temporal Variation of Alkaloids in Annona purpurea and the Associated Influence on Their Antifungal Activity. Chem Biodivers  2019; 16(2)e1800284
[PMID:  30471185] 
[167] 
Lingaraju DP, Sudarshana MS, Rajashekar N. Ethnopharmacological survey of traditional medicinal plants in tribal areas of Kodagu district, Karnataka, India. J Pharm Res  2013; 6: 284-97.
[http://dx.doi.org/10.1016/j.jopr.2013.02.012] 
[168] 
Panda SK. Ethno-medicinal uses and screening of plants for antibacterial activity from Similipal Biosphere Reserve, Odisha, India. J Ethnopharmacol  2014; 151(1): 158-75.
[http://dx.doi.org/10.1016/j.jep.2013.10.004] [PMID:  24177353] 
[169] 
Wagh VV, Jain AK. Ethnopharmacological survey of plants used by the Bhil and Bhilala ethnic community in dermatological disorders in Western Madhya Pradesh, India. J Herb Med  2020; 19100234
[http://dx.doi.org/10.1016/j.hermed.2018.09.005] 
[170] 
Roy Choudhury P, Dutta Choudhury M, Ningthoujam SS, Das D, Nath D, Das Talukdar A. Ethnomedicinal plants used by traditional healers of North Tripura district, Tripura, North East India. J Ethnopharmacol  2015; 166: 135-48.
[http://dx.doi.org/10.1016/j.jep.2015.03.026] [PMID:  25794807] 
[171] 
Policepatel SS, Manikrao VG. Ethnomedicinal plants used in the treatment of skin diseases in Hyderabad Karnataka region, Karnataka, India. Asian Pac J Trop Biomed  2013; 3(11): 882-6.
[http://dx.doi.org/10.1016/S2221-1691(13)60173-2] 
[172] 
Vera-Ku M, Méndez-González M, Moo-Puc R, et al. Medicinal potions used against infectious bowel diseases in Mayan traditional medicine. J Ethnopharmacol  2010; 132(1): 303-8.
[http://dx.doi.org/10.1016/j.jep.2010.08.040] [PMID:  20728517] 
[173] 
Panda SK, Mohanta YK, Padhi L, Park YH, Mohanta TK, Bae H. Large Scale Screening of Ethnomedicinal Plants for Identification of Potential Antibacterial Compounds. Molecules  2016; 21(3): 293.
[http://dx.doi.org/10.3390/molecules21030293] [PMID:  26985889] 
[174] 
Jamkhande PG, Wattamwar AS, Kankudte AD, Tidke PS, Kalaskar MG. Assessment of Annona reticulata Linn. leaves fractions for invitro antioxidative effect and antimicrobial potential against standard human pathogenic strains. Alexandria J Med  2016; 52: 19-25.
[http://dx.doi.org/10.1016/j.ajme.2014.12.007] 
[175] 
Jamkhande PG, Wattamwar AS, Pekamwar SS, Chandak PG. Antioxidant, antimicrobial activity and in silico PASS prediction of Annona reticulata Linn. root extract. BJBAS  2014; 3: 140-8.
[http://dx.doi.org/10.1016/j.bjbas.2014.05.008] 
[176] 
Devi TS, Padmaja IJ, Santry YN, Nagamani A. A study on anti dermatophytic potential of selected ethno medicinal plants against Trichophyton rubrum, a common etiologic agent in and around Visakhapatnam region (India). Asian Pac J Trop Biomed  2012; 2(3): S1874-8.
[http://dx.doi.org/10.1016/S2221-1691(12)60512-7] 
[177] 
Kandimalla R, Dash S, Kalita S, et al. Bioactive Fraction of Annona reticulata Bark (or) Ziziphus jujuba Root Bark along with Insulin Attenuates Painful Diabetic Neuropathy through Inhibiting NF-κB Inflammatory Cascade. Front Cell Neurosci  2017; 11: 73.
[http://dx.doi.org/10.3389/fncel.2017.00073] [PMID:  28381989] 
[178] 
Mohankumar TK, Shivanna KS, Achuttan VV. Screening of Methanolic Plant Extracts against Larvae of Aedes aegypti and Anopheles stephensi in Mysore. J Arthropod Borne Dis  2016; 10(3): 303-14.
[PMID:  27308289] 
[179] 
Roham PH, Kharat KR, Mungde P, Jadhav MA, Makhija SJ. Induction of mitochondria mediated apoptosis in human breast cancer cells (T-47D) by Annona reticulata L. leaves methanolic extracts. Nutr Cancer  2016; 68(2): 305-11.
[http://dx.doi.org/10.1080/01635581.2016.1142583] [PMID:  26908199] 
[180] 
Suresh HM, Shivakumar B, Hemalatha K, Heroor SS, Hugar DS, Rao KRSS. In vitro antiproliferativeactivity of Annona reticulata roots on human cancer cell lines. Pharmacognosy Res  2011; 3(1): 9-12.
[http://dx.doi.org/10.4103/0974-8490.79109] [PMID:  21731389] 
[181] 
Chavan MJ, Wakte PS, Shinde DB. Analgesic and anti-inflammatory activities of the sesquiterpene fraction from Annona reticulata L. bark. Nat Prod Res  2012; 26(16): 1515-8.
[http://dx.doi.org/10.1080/14786419.2011.564583] [PMID:  22007723] 
[182] 
Ibrahim A, Umar IA, Aimola IA, Mohammed A. Inhibition of key enzymes linked to diabetes by Annona senegalensis Pers (Annonaceae) leaf in vitro. J Herb Med  2019; 16100248
[http://dx.doi.org/10.1016/j.hermed.2018.11.004] 
[183] 
Ashidi JS, Houghton PJ, Hylands PJ, Efferth T. Ethnobotanical survey and cytotoxicity testing of plants of South-western Nigeria used to treat cancer, with isolation of cytotoxic constituents from Cajanus cajan Millsp. leaves. J Ethnopharmacol  2010; 128(2): 501-12.
[http://dx.doi.org/10.1016/j.jep.2010.01.009] [PMID:  20064598] 
[184] 
Baldé AM, Traoré MS, Baldé MA, et al. Ethnomedical and ethnobotanical investigations on the response capacities of Guinean traditional health practioners in the management of outbreaks of infectious diseases: The case of the Ebola virus epidemic. J Ethnopharmacol  2016; 182: 137-49.
[http://dx.doi.org/10.1016/j.jep.2016.02.021] [PMID:  26900129] 
[185] 
Salihu T, Olukunle JO, Adenubi OT, Mbaoji C, Zarma MH. Ethnomedicinal plant species commonly used to manage arthritis in North-West Nigeria. S Afr J Bot  2018; 118: 33-43.
[http://dx.doi.org/10.1016/j.sajb.2018.06.004] 
[186] 
Dlova NC, Ollengo MA. Traditional and ethnobotanical dermatology practices in Africa. Clin Dermatol  2018; 36(3): 353-62.
[http://dx.doi.org/10.1016/j.clindermatol.2018.03.009] [PMID:  29908577] 
[187] 
Salihu Shinkafi T, Bello L, Wara Hassan S, Ali S. An ethnobotanical survey of antidiabetic plants used by Hausa-Fulani tribes in Sokoto, Northwest Nigeria. J Ethnopharmacol  2015; 172: 91-9.
[http://dx.doi.org/10.1016/j.jep.2015.06.014] [PMID:  26117532] 
[188] 
Mahwasane ST, Middleton L, Boaduo N. An ethnobotanical survey of indigenous knowledge on medicinal plants used by the traditional healers of the Lwamondo area, Limpopo province, South Africa. S Afr J Bot  2013; 88: 69-75.
[http://dx.doi.org/10.1016/j.sajb.2013.05.004] 
[189] 
Bruschi P, Morganti M, Mancini M, Signorini MA. Traditional healers and laypeople: a qualitative and quantitative approach to local knowledge on medicinal plants in Muda (Mozambique). J Ethnopharmacol  2011; 138(2): 543-63.
[http://dx.doi.org/10.1016/j.jep.2011.09.055] [PMID:  22008876] 
[190] 
Ahmed AL, Bassem SEM, Mohamed YH, Gamila MW. Cytotoxic essential oil from Annona sengalensis Pers. leaves. Pharmacognosy Res  2010; 2(4): 211-4.
[http://dx.doi.org/10.4103/0974-8490.69105] [PMID:  21808569] 
[191] 
Yeo D, Dinica R, Yapi HF, et al. Évaluation de l’activité anti-inflammatoire et screening phytochimique des feuilles de Annona senegalensis. Therapie  2011; 66(1): 73-80.
[http://dx.doi.org/10.2515/therapie/2010076] [PMID:  21466781] 
[192] 
Okoye TC, Akah PA, Omeke CP. Evaluation of the anticonvulsant and muscle relaxant effects of the methanol root bark extracts of Annona senegalensis. Asian Pac J Trop Biomed  2010; 3(1): 25-8.
[http://dx.doi.org/10.1016/S1995-7645(10)60025-9] 
[193] 
Ohashi M, Amoa-Bosompem M, Kwofie KD, et al. In vitro antiprotozoan activity and mechanisms of action of selected Ghanaian medicinal plants against Trypanosoma, Leishmania, and Plasmodium parasites. Phytother Res  2018; 32(8): 1617-30.
[http://dx.doi.org/10.1002/ptr.6093] [PMID:  29733118] 
[194] 
Teufack SEN, Tayo GN, Alidou MN, et al. Anthelminthic properties of Methylene chloride-methanol (1:1) extracts of two Cameroonians medicinal plants on Heligmosomoides bakeri (Nematoda: Heligmosomatidea). BMC Complement Altern Med  2017; 17(1): 1-7.
[PMID:  28049463] 
[195] 
Lame Y, Nukenine EN, Pierre DY, Elijah AE, Esimone CO. Laboratory Evaluations of the Fractions Efficacy of Annona senegalensis (Annonaceae) Leaf Extract on Immature Stage Development of Malarial and Filarial Mosquito Vectors. J Arthropod Borne Dis  2015; 9(2): 226-37.
[PMID:  26623434] 
[196] 
Ajboye TO, Yakubu MT, Salau AK, Oladiji AT, Akanji MA, Okogun JI. Antioxidant and drug detoxification potential of aqueous extract of Annona senegalensis leaves in carbon tetrachloride-induced hepatocellular damage. Pharm Biol  2010; 48(12): 1361-70.
[http://dx.doi.org/10.3109/13880209.2010.483247] [PMID:  20815700] 
[197] 
Ngwewondo A, Tsague Manfo FP, Samje M, Monya E, Cho-Ngwa F. Macro and microfilaricidal activities of extracts of Annona senegalensis and Milletia comosa against Onchocerca ochengi and Loa loa. Exp Parasitol  2019; 198: 71-8.
[http://dx.doi.org/10.1016/j.exppara.2019.02.004] [PMID:  30771293] 
[198] 
Makhuvele R, Matshoga RG, Antonissen R, Pieters L, Verschaeve L, Elgorashi EE. Genotoxicity and Antigenotoxicity of selected South African indigenous plants. S Afr J Bot  2018; 114: 89-99.
[http://dx.doi.org/10.1016/j.sajb.2017.10.016] 
[199] 
Molander M, Nielsen L, Søgaard S, et al. Hyaluronidase, phospholipase A2 and protease inhibitory activity of plants used in traditional treatment of snakebite-induced tissue necrosis in Mali, DR Congo and South Africa. J Ethnopharmacol  2014; 157: 171-80.
[http://dx.doi.org/10.1016/j.jep.2014.09.027] [PMID:  25256691] 
[200] 
Balamurugan S, Vijayakumar S, Prabhu S, Morvin Yabesh JE. Traditional plants used for the treatment of gynaecological disorders in Vedaranyam taluk, South India - An ethnomedicinal survey. J Tradit Complement Med  2017; 8(2): 308-23.
[http://dx.doi.org/10.1016/j.jtcme.2017.06.009] [PMID:  29736387] 
[201] 
Upadhyay B. Parveen, Dhaker AK, Kumar A. Ethnomedicinal and ethnopharmaco-statistical studies of Eastern Rajasthan, India. J Ethnopharmacol  2010; 129(1): 64-86.
[http://dx.doi.org/10.1016/j.jep.2010.02.026] [PMID:  20214972] 
[202] 
Chinnasamy P, Arumugam R, Ariyan S. In silico validation of the indigenous knowledge of the herbal medicines among tribal communities in Sathyamangalam wildlife sanctuary, India. J Tradit Complement Med  2018; 9(2): 143-55.
[http://dx.doi.org/10.1016/j.jtcme.2018.01.008] [PMID:  30963049] 
[203] 
Samoisy AK, Mahomoodally F. Ethnopharmacological appraisal of culturally important medicinal plants and polyherbal formulas used against communicable diseases in Rodrigues Island. J Ethnopharmacol  2016; 194: 803-18.
[http://dx.doi.org/10.1016/j.jep.2016.10.041] [PMID:  27816659] 
[204] 
Ranjarisoa LN, Razanamihaja N, Rafatro H. Use of plants in oral health care by the population of Mahajanga, Madagascar. J Ethnopharmacol  2016; 193: 179-94.
[http://dx.doi.org/10.1016/j.jep.2016.07.076] [PMID:  27496581] 
[205] 
Li DL, Xing FW. Ethnobotanical study on medicinal plants used by local Hoklos people on Hainan Island, China. J Ethnopharmacol  2016; 194: 358-68.
[http://dx.doi.org/10.1016/j.jep.2016.07.050] [PMID:  27444693] 
[206] 
Swain SS, Padhy RN. In vitroantibacterial efficacy of plants used by an Indian aboriginaltribe against pathogenic bacteria isolated from clinical samples. J Taibah Univ Med Sci  2015; 10(4): 379-90.
[207] 
Vijayakumar S, Morvin Yabesh JE, Prabhu S, Manikandan R, Muralidharan B. Quantitative ethnomedicinal study of plants used in the Nelliyampathy hills of Kerala, India. J Ethnopharmacol  2015; 161: 238-54.
[http://dx.doi.org/10.1016/j.jep.2014.12.006] [PMID:  25529616] 
[208] 
Abe R, Ohtani K. An ethnobotanical study of medicinal plants and traditional therapies on Batan Island, the Philippines. J Ethnopharmacol  2013; 145(2): 554-65.
[http://dx.doi.org/10.1016/j.jep.2012.11.029] [PMID:  23183086] 
[209] 
Bhat P, Hegde G, Hegde GR. Ethnomedicinal practices in different communities of Uttara Kannada district of Karnataka for treatment of wounds. J Ethnopharmacol  2012; 143(2): 501-14.
[http://dx.doi.org/10.1016/j.jep.2012.07.003] [PMID:  22820243] 
[210] 
David BC, Gudivada S. Ethnomedicinal plant knowledge and practice of people of Javadhu hills in Tamilnadu. Asian Pac J Trop Biomed  2011; 1: 79-81.
[http://dx.doi.org/10.1016/S2221-1691(11)60129-9] 
[211] 
Silambarasan R, Ayyanar M. An ethnobotanical study of medicinal plants in Palamalai region of Eastern Ghats, India. J Ethnopharmacol  2015; 172(22): 162-78.
[http://dx.doi.org/10.1016/j.jep.2015.05.046] [PMID:  26068426] 
[212] 
Yabesh JEM, Prabhu S, Vijayakumar S. An ethnobotanical study of medicinal plants used by traditional healers in silent valley of Kerala, India. J Ethnopharmacol  2014; 154(3): 774-89.
[http://dx.doi.org/10.1016/j.jep.2014.05.004] [PMID:  24832113] 
[213] 
Mohamad S, Zin NM, Wahab HA, et al. Antituberculosis potential of some ethnobotanically selected Malaysian plants. J Ethnopharmacol  2011; 133(3): 1021-6.
[http://dx.doi.org/10.1016/j.jep.2010.11.037] [PMID:  21094237] 
[214] 
Prabhu S, Vijayakumar S, Yabesh JEM, Ravichandran K, Sakthivel B. Documentation and quantitative analysis of the local knowledge on medicinal plants in Kalrayan hills of Villupuram district, Tamil Nadu, India. J Ethnopharmacol  2014; 157: 7-20.
[http://dx.doi.org/10.1016/j.jep.2014.09.014] [PMID:  25240590] 
[215] 
Tarak D, Namsa ND, Tangjang S, et al. An inventory of the ethnobotanicals used as anti-diabetic by a rural community of Dhemaji district of Assam, Northeast India. J Ethnopharmacol  2011; 138(2): 345-50.
[http://dx.doi.org/10.1016/j.jep.2011.08.018] [PMID:  21871548] 
[216] 
Silva Fdos S, Albuquerque UP, Costa Júnior LM, Lima Ada S, do Nascimento AL, Monteiro JM. An ethnopharmacological assessment of the use of plants against parasitic diseases in humans and animals. J Ethnopharmacol  2014; 155(2): 1332-41.
[http://dx.doi.org/10.1016/j.jep.2014.07.036] [PMID:  25072360] 
[217] 
Sivasankari B, Anandharaj M, Gunasekaran P. An ethnobotanical study of indigenous knowledge on medicinal plants used by the village peoples of Thoppampatti, Dindigul district, Tamilnadu, India. J Ethnopharmacol  2014; 153(2): 408-23.
[http://dx.doi.org/10.1016/j.jep.2014.02.040] [PMID:  24583241] 
[218] 
Inta A, Trisonthi P, Trisonthi C. Analysis of traditional knowledge in medicinal plants used by Yuan in Thailand. J Ethnopharmacol  2013; 149(1): 344-51.
[http://dx.doi.org/10.1016/j.jep.2013.06.047] [PMID:  23850711] 
[219] 
Mallik BK, Panda T, Padhy RN. Ethnoveterinary practices of aborigine tribes in Odisha, India. Asian Pac J Trop Biomed  2012; 2: S1520-5.
[http://dx.doi.org/10.1016/S2221-1691(12)60447-X] 
[220] 
Chen Y, Chen Y, Shi Y, et al. Antitumor activity of Annona squamosa seed oil. J Ethnopharmacol  2016; 193: 362-7.
[http://dx.doi.org/10.1016/j.jep.2016.08.036] [PMID:  27566205] 
[221] 
Chen Y, Xu SS, Chen JW, et al. Anti-tumor activity of Annona squamosa seeds extract containing annonaceous acetogenin compounds. J Ethnopharmacol  2012; 142(2): 462-6.
[http://dx.doi.org/10.1016/j.jep.2012.05.019] [PMID:  22609808] 
[222] 
Nandhakumar E, Indumathi P. In vitro antioxidant activities of methanol and aqueous extract of Annona squamosa (L.) fruit pulp. J Acupunct Meridian Stud  2013; 6(3): 142-8.
[http://dx.doi.org/10.1016/j.jams.2012.09.002] [PMID:  23787283] 
[223] 
Huang WY, Cai YZ, Corke H, Sun M. Survey of antioxidant capacity and nutritional quality of selected edible and medicinal fruit plants in Hong Kong. J Food Compos Anal  2010; 23: 510-7.
[http://dx.doi.org/10.1016/j.jfca.2009.12.006] 
[224] 
Davis JA, Sharma S, Mittra S, et al. Antihyperglycemic effect of Annona squamosa hexane extract in type 2 diabetes animal model: PTP1B inhibition, a possible mechanism of action? Indian J Pharmacol  2012; 44(3): 326-32.
[http://dx.doi.org/10.4103/0253-7613.96304] [PMID:  22701240] 
[225] 
Bhoir SS, Vishwapathi V, Singh KK. Antipsoriatic potential of Annona squamosa seed oil: An in vitro and in vivo evaluation. Phytomedicine  2019; 54: 265-77.
[http://dx.doi.org/10.1016/j.phymed.2018.07.003] [PMID:  30668377] 
[226] 
Sun Q, Zhang B, Yan QJ, Jiang ZQ. Comparative analysis on the distribution of protease activities among fruits and vegetable resources. Food Chem  2016; 213: 708-13.
[http://dx.doi.org/10.1016/j.foodchem.2016.07.029] [PMID:  27451238] 
[227] 
Vikas B, Akhil BS. P R, Sujathan K. Free Radical Scavenging Properties of Annona squamosa. Asian Pac J Cancer Prev  2017; 18(10): 2725-31.
[PMID:  29072399] 
[228] 
Manochai B, Ingkasupart P, Lee SH, Hong JH. Evaluation of antioxidant activities, total phenolic content (TPC), and total catechin content (TCC) of 10 sugar apple (Annona squamosa L.) cultivar peels grown in Thailand. Food Sci Technol  2018; 38(Suppl. 1): 294-300.
[http://dx.doi.org/10.1590/fst.22117] 
[229] 
Alkhawalidy ASR, Hossain MA. Study on total phenolics and antioxidant activity of leaves crude extracts of Annona squamosa traditionally used for the treatment of cancerous tumours. Asian Pac J Trop Dis  2015; 5(Suppl. 1): S142-4.
[http://dx.doi.org/10.1016/S2222-1808(15)60876-3] 
[230] 
Reddy CVK, Sreeramulu D, Raghunath M. Antioxidant activity of fresh and dry fruits commonly consumed in India. Food Res Int  2010; 43: 285-8.
[http://dx.doi.org/10.1016/j.foodres.2009.10.006] 
[231] 
Kowitcharoen L, Aree CW, Setha S, Komkhuntod R, Srilaong V, Kondo S. Changes in abscisic acid and antioxidant activity in sugar apples under drought conditions. Sci Hortic (Amsterdam)  2015; 193: 1-6.
[http://dx.doi.org/10.1016/j.scienta.2015.06.043] 
[232] 
Pinto NCC, Silva JB, Menegati LM, et al. Cytotoxicity and bacterial membrane destabilization induced by Annona squamosa L. extracts. An Acad Bras Cienc  2017; 89(3)(Suppl.): 2053-73.
[http://dx.doi.org/10.1590/0001-3765201720150702] [PMID:  28813096] 
[233] 
Chaghaby GAE, Ahmad AF, Ramis ES. Evaluation of the antioxidant and antibacterial properties of various solvents extracts of Annona squamosa L. leaves. Arab J Chem  2014; 7: 227-33.
[http://dx.doi.org/10.1016/j.arabjc.2011.06.019] 
[234] 
Dholvitayakhun A, Trachoo N, Narkkong NA, Cushnie TPT. Using scanning and transmission electron microscopy to investigate the antibacterial mechanism of action of the medicinal plant Annona squamosa Linn. J Herb Med  2017; 7: 31-6.
[http://dx.doi.org/10.1016/j.hermed.2016.10.003] 
[235] 
Li F, Li S, Li HB, et al. Antiproliferative activity of peels, pulps and seeds of 61 fruits. J Funct Foods  2013; 5: 1298-309.
[http://dx.doi.org/10.1016/j.jff.2013.04.016] 
[236] 
Wang DS, Rizwani GH, Guo H, et al. Annona squamosa Linn: atividade citotóxica encontrada no extrato de folhas contra linhagens tumorais humanas. Pak J Pharm Sci  2014; 27(5): 1559-63.
[PMID:  25176251] 
[237] 
Madhumitha G, Rajakumar G, Roopan SM, et al. Acaricidal, insecticidal, and larvicidal efficacy of fruit peel aqueous extract of Annona squamosa and its compounds against blood-feeding parasites. Parasitol Res  2012; 111(5): 2189-99.
[http://dx.doi.org/10.1007/s00436-011-2671-2] [PMID:  22006187] 
[238] 
Ramanibai R, Parthiban E, Boothapandi M. Effect of seed kernel aqueous extract from Annona squamosa against three mosquito vectors and its impact on non-target aquatic organisms. Asian Pac J Trop Dis  2016; 6(9): 741-5.
[http://dx.doi.org/10.1016/S2222-1808(16)61121-0] 
[239] 
Almeida FAC, Júnior PJS, Queiroga VP, Neto AF, Olivier NC, Rojas ABG. Eficiencia de extractos vegetales como insecticida sobre Sitophilus zeamais en granos de maíz almacenados. Rev Cienc Téc Agropecu  2014; 23(2): 57-62.
[240] 
Kempraj V, Bhat SK. Acute and reproductive toxicity of Annona squamosa to Aedes albopictus. Pestic Biochem Physiol  2011; 100: 82-6.
[http://dx.doi.org/10.1016/j.pestbp.2011.02.009] 
[241] 
Seffrin RC, Shikano I, Akhtar Y, Isman MB. Effects of crude seed extracts of Annona atemoya and Annona squamosa L. against the cabbage looper, Trichoplusia ni in the laboratory and greenhouse. Crop Prot  2010; 29: 20-4.
[http://dx.doi.org/10.1016/j.cropro.2009.09.003] 
[242] 
Singh N, Kaushik NK, Mohanakrishnan D, Tiwari SK, Sahal D. Antiplasmodial activity of medicinal plants from Chhotanagpur plateau, Jharkhand, India. J Ethnopharmacol  2015; 165: 152-62.
[http://dx.doi.org/10.1016/j.jep.2015.02.038] [PMID:  25721804] 
[243] 
Sachan A, Shanker D, Jaiswal AK, Sudan V. In vitro ovicidal assessment of methanol, ethyl acetate and chloroform extracts of Annona squamosa and Chenopodium album against caprine gastrointestinal nematodiosis. J Parasit Dis  2015; 39(1): 62-6.
[http://dx.doi.org/10.1007/s12639-013-0288-3] [PMID:  25698862] 
[244] 
Kamaraj C, Rahuman AA. Efficacy of anthelmintic properties of medicinal plant extracts against Haemonchus contortus. Res Vet Sci  2011; 91(3): 400-4.
[http://dx.doi.org/10.1016/j.rvsc.2010.09.018] [PMID:  20980034] 
[245] 
Ponrasu T, Suguna L. Efficacy of Annona squamosa on wound healing in streptozotocin-induced diabetic rats. Int Wound J  2012; 9(6): 613-23.
[http://dx.doi.org/10.1111/j.1742-481X.2011.00924.x] [PMID:  22233431] 
[246] 
Deshmukh AB, Patel JK. Aqueous extract of Annona squamosa (L.) ameliorates renal failure induced by 5/6 nephrectomy in rat. Indian J Pharmacol  2011; 43(6): 718-21.
[PMID:  22144782] 
[247] 
Ibrahim RYM, Hassan AI, Al-Adham EK. The anti-ulcerative colitis effects of Annona squamosa Linn. leaf aqueous extract in experimental animal model. Int J Clin Exp Med  2015; 8(11): 21861-70.
[PMID:  26885156] 
[248] 
Kalidindi N, Thimmaiah NV, Jagadeesh NV, Nandeep R, Swetha S, Kalidindi B. Antifungal and antioxidant activities of organic and aqueous extracts of Annona squamosa Linn. leaves. Yao Wu Shi Pin Fen Xi  2015; 23(4): 795-802.
[http://dx.doi.org/10.1016/j.jfda.2015.04.012] [PMID:  28911497] 
[249] 
Urso V, Signorini MA, Tonini M, Bruschi P. Wild medicinal and food plants used by communities living in Mopane woodlands of southern Angola: Results of an ethnobotanical field investigation. J Ethnopharmacol  2016; 177: 126-39.
[http://dx.doi.org/10.1016/j.jep.2015.11.041] [PMID:  26639153] 
[250] 
Chinsembu KC, Hijarunguru A, Mbangu A. Ethnomedicinal plants used by traditional healers in the management of HIV/AIDS opportunistic diseases in Rundu, Kavango East Region, Namibia. S Afr J Bot  2015; 100: 33-42.
[http://dx.doi.org/10.1016/j.sajb.2015.05.009] 
[251] 
Maroyi A. An ethnobotanical survey of medicinal plants used by the people in Nhema communal area, Zimbabwe. J Ethnopharmacol  2011; 136(2): 347-54.
[http://dx.doi.org/10.1016/j.jep.2011.05.003] [PMID:  21575701] 
[252] 
Lautenschläger T, Monizi M, Pedro M, et al. First large-scale ethnobotanical survey in the province of Uíge, northern Angola. J Ethnobiol Ethnomed  2018; 14(1): 51.
[http://dx.doi.org/10.1186/s13002-018-0238-3] [PMID:  30045744] 
[253] 
Khallouki F, Haubner R, Ulrich CM, Owen RW. Ethnobotanical survey, chemical composition, and antioxidant capacity of methanolic extract of the root bark of Annona cuneata Oliv. J Med Food  2011; 14(11): 1397-402.
[http://dx.doi.org/10.1089/jmf.2010.0228] [PMID:  21870939] 
[254] 
Formagio ASN, Vieira Mdo C, Dos Santos LA, et al. Composition and evaluation of the anti-inflammatory and anticancer activities of the essential oil from Annona sylvatica A. St.-Hil. J Med Food  2013; 16(1): 20-5.
[http://dx.doi.org/10.1089/jmf.2011.0303] [PMID:  23297712] 
[255] 
Carneiro LU, da Silva IG, de Souza MEA, Côrtes WDS, de Carvalho MG, Marinho BG. Antinociceptive and anti-inflammatory activities of leaf extracts from Annona tomentosa R.E.Fr. J Integr Med  2017; 15(5): 379-87.
[http://dx.doi.org/10.1016/S2095-4964(17)60349-2] [PMID:  28844215] 
[256] 
Araujo RCP, Neves FAR, Formagio ASN, et al. Evaluation of the anti-mycobacterium tuberculosis activity and in vivo acute toxicity of Annona sylvatic. BMC Complement Altern Med  2014; 14(1): 209.
[http://dx.doi.org/10.1186/1472-6882-14-209] [PMID:  24974069] 
[257] 
Diniz TC, de Oliveira Júnior RG, Miranda Bezerra Medeiros MA, et al. Anticonvulsant, sedative, anxiolytic and antidepressant activities of the essential oil of Annona vepretorum in mice: Involvement of GABAergic and serotonergic systems. Biomed Pharmacother  2019; 111: 1074-87.
[http://dx.doi.org/10.1016/j.biopha.2018.12.114] [PMID:  30841421] 
[258] 
Bomfim LM, Menezes LRA, Rodrigues ACBC, et al. Antitumour Activity of the Microencapsulation of Annona vepretorum Essential Oil. Basic Clin Pharmacol Toxicol  2016; 118(3): 208-13.
[http://dx.doi.org/10.1111/bcpt.12488] [PMID:  26348780] 
[259] 
Fernandes MHA, Menezes KO, Souza AM, Almeida JRGS, Oliveira JEM, Gervásio RCRG. Bioactivity of the organic extracts of Annona vepretorum on Tetranychus urticae (Acari: Tetranychidae). Pesqui Agropecu Bras  2017; 52(9): 707-14.
[http://dx.doi.org/10.1590/s0100-204x2017000900002] 
[260] 
Almeida JRGS, Araújo CS, Pessoa CO, Costa MP, Pacheco AGM. Atividade antioxidante,citotóxica e antimicrobiana de Annona vepretorum Mart. (Annonaceae). Rev Bras Frutic  2014; 36: 258-64.
[http://dx.doi.org/10.1590/S0100-29452014000500030] 
[261] 
Silva JC, Macedo LARO, Souza GR, et al. Orofacial antinociceptive effect of the ethanolic extract of Annona vepretorum Mart. (Annonaceae). Z Natforsch C J Biosci  2016; 71(7-8): 209-14.
[http://dx.doi.org/10.1515/znc-2015-5024] [PMID:  27269894] 
[262] 
Silva JC, Araújo Cde S, de Lima-Saraiva SR, et al. Antinociceptive and anti-inflammatory activities of the ethanolic extract of Annona vepretorum Mart. (Annonaceae) in rodents. BMC Complement Altern Med  2015; 15(1): 197.
[http://dx.doi.org/10.1186/s12906-015-0716-2] [PMID:  26104689] 
[263] 
Paes MM, Vega MRG, Cortes D, Kanashiro MM. Potencial Citotóxico das Acetogeninas do Gênero Annona. Rev Virtual Quim  2016; 8(3): 945-80.
[264] 
Santos SAO, Vilela C, Camacho JF, et al. Profiling of lipophilic and phenolic phytochemicals of four cultivars from cherimoya (Annona cherimola Mill.). Food Chem  2016; 211: 845-52.
[http://dx.doi.org/10.1016/j.foodchem.2016.05.123] [PMID:  27283704] 
[265] 
Luzia DMM, Jorge N. Bioactive substance contents and antioxidant capacity of the lipid fraction of Annona crassiflora Mart. Seeds. Ind Crops Prod  2013; 42: 231-5.
[http://dx.doi.org/10.1016/j.indcrop.2012.05.027] 
[266] 
Arruda HS, Pereira GA, de Morais DR, Eberlin MN, Pastore GM. Determination of free, esterified, glycosylated and insoluble-bound phenolics composition in the edible part of araticum fruit (Annona crassiflora Mart.) and its by-products by HPLC-ESI-MS/MS. Food Chem  2018; 245: 738-49.
[http://dx.doi.org/10.1016/j.foodchem.2017.11.120] [PMID:  29287435] 
[267] 
Arruda HS, Silva EK, Pereira GA, et al. Effects of high-intensity ultrasound process parameters on the phenolic compounds recovery from araticum peel. Ultrason Sonochem  2019; 50: 82-95.
[http://dx.doi.org/10.1016/j.ultsonch.2018.09.002] [PMID:  30201331] 
[268] 
Novaes P, Ferreira MJP, Santos DYAC. Flavonols from Annona coriacea Mart. (Annonaceae). Biochem Syst Ecol  2018; 78: 77-80.
[http://dx.doi.org/10.1016/j.bse.2018.04.006] 
[269] 
Lima LARS, Pimenta LPS, Boaventura MAD. Acetogenins from Annona cornifolia and their antioxidant capacity. Food Chem  2010; 122: 1129-38.
[http://dx.doi.org/10.1016/j.foodchem.2010.03.100] 
[270] 
Lima LARS, Alves TMA, Zani CL, et al. In vitro cytotoxic, antifungal, trypanocidal and leishmanicidal activities of acetogenins isolated from Annona cornifolia A. St. -Hil. (Annonaceae). An Acad Bras Cienc  2014; 86(2): 829-39.
[http://dx.doi.org/10.1590/0001-3765201420130048] [PMID:  30514008] 
[271] 
Costa EV, Pinheiro MLB, de Souza AD, et al. Trypanocidal activity of oxoaporphine and pyrimidine-β-carboline alkaloids from the branches of Annona foetida Mart. (Annonaceae). Molecules  2011; 16(11): 9714-20.
[http://dx.doi.org/10.3390/molecules16119714] [PMID:  22113579] 
[272] 
Hien NTT, Nhiem NX, Yen DTH, et al. Chemical constituents of the Annona glabra fruit and their cytotoxic activity. Pharm Biol  2015; 53(11): 1602-7.
[http://dx.doi.org/10.3109/13880209.2014.993042] [PMID:  25856711] 
[273] 
Nhiem NX, Hien NTT, Tai BH, et al. New ent-kauranes from the fruits of Annona glabra and their inhibitory nitric oxide production in LPS-stimulated RAW264.7 macrophages. Bioorg Med Chem Lett  2015; 25(2): 254-8.
[http://dx.doi.org/10.1016/j.bmcl.2014.11.059] [PMID:  25499882] 
[274] 
Rodrigues CMSC, Dutra LM, Barison A, Costa EV, Almeida JRGS. Isoquinoline alkaloids from the leaves of Annona leptopetala (Annonaceae). Biochem Syst Ecol  2016; 69: 222-5.
[http://dx.doi.org/10.1016/j.bse.2016.10.002] 
[275] 
Baskaran R, Pullencheri D, Somasundaram R. Characterization of free, esterified and bound phenolics in custard apple (Annona squamosa L) fruit pulp by UPLC-ESI-MS/MS. Food Res Int  2016; 82: 121-7.
[http://dx.doi.org/10.1016/j.foodres.2016.02.001] 
[276] 
Abdualrahman MAY, Ma H, Zhou C, et al. Postharvest physicochemical properties of the pulp and seed oil from Annona squamosa L. (Gishta) fruit grown in Darfur region, Sudan. Arab J Chem  2019; 12(8): 4514-21.
[http://dx.doi.org/10.1016/j.arabjc.2016.07.008] 
[277] 
Miao Y, Xu X, Yuan F, et al. Four cytotoxic annonaceous acetogenins from the seeds of Annona squamosa. Nat Prod Res  2016; 30(11): 1273-9.
[http://dx.doi.org/10.1080/14786419.2015.1055490] [PMID:  26181648] 
[278] 
Jayendra Kumar Y. New compound 6,7-dimethoxy-2- methylisoquinolinium from Indian medicinal plant Annona squamosa L IJCAS 2013; 4: 161-8.
[279] 
Araújo CD, de Oliveira AP, Lima RN, Alves PB, Diniz TC, da Silva Almeida JR. Constituintes químicos e atividade antioxidante do óleo essencial de folhas de Annona vepretorum Mart. (Annonaceae). Pharmacogn Mag  2015; 11: 615-8.
[http://dx.doi.org/10.4103/0973-1296.160462] [PMID:  26246740] 
[280] 
Dutra LM, Bomfim LM, Rocha SLA, et al. ent-Kaurane diterpenes from the stem bark of Annona vepretorum (Annonaceae) and cytotoxic evaluation. Bioorg Med Chem Lett  2014; 24(15): 3315-20.
[http://dx.doi.org/10.1016/j.bmcl.2014.06.005] [PMID:  24969014] 
[281] 
Pereira MN, Justino AB, Martins MM, et al. Stephalagine, an alkaloid with pancreatic lipase inhibitory activity isolated from the fruit peel of Annona crassiflora Mart. Ind Crops Prod  2017; 97: 324-9.
[http://dx.doi.org/10.1016/j.indcrop.2016.12.038] 
[282] 
Lage GA, Medeiros Fda S, Furtado Wde L, Takahashi JÁ, de Souza Filho JD, Pimenta LPS. The first report on flavonoid isolation from Annona crassiflora Mart. Nat Prod Res  2014; 28(11): 808-11.
[http://dx.doi.org/10.1080/14786419.2014.885518] [PMID:  24571732] 
[283] 
Dolab JG, Lima B, Spaczynska E, et al. The Antimicrobial Activity of Annona emarginata (Schltdl.) H. Rainer and Most Active Isolated Compounds against Clinically Important Bacteria. Molecules  2018; 23(5): 1-14.
[http://dx.doi.org/10.3390/molecules23051187] [PMID:  29772647] 
[284] 
Rinaldi MVN, Díaz IEC, Suffredini IB, Paulo RH, Moreno PRH. Alkaloids and biological activity of beribá (Annona hypoglauca). Rev Bras Farmacogn  2017; 27: 77-83.
[http://dx.doi.org/10.1016/j.bjp.2016.08.006] 
[285] 
Sun S, Liu J, Zhou N, Zhu W, Dou QP, Zhou K. Isolation of three new annonaceous acetogenins from Graviola fruit (Annona muricata) and their anti-proliferation on human prostate cancer cell PC-3. Bioorg Med Chem Lett  2016; 26(17): 4382-5.
[http://dx.doi.org/10.1016/j.bmcl.2015.06.038] [PMID:  27499453] 
[286] 
Sun S, Liu J, Kadouh H, Sun X, Zhou K. Three new anti-proliferative Annonaceous acetogenins with mono-tetrahydrofuran ring from graviola fruit (Annona muricata). Bioorg Med Chem Lett  2014; 24(12): 2773-6.
[http://dx.doi.org/10.1016/j.bmcl.2014.03.099] [PMID:  24780120] 
[287] 
Nawwar M, Ayoub N, Hussein S, et al. A flavonol triglycoside and investigation of the antioxidant and cell stimulating activities of Annona muricata Linn. Arch Pharm Res  2012; 35(5): 761-7.
[http://dx.doi.org/10.1007/s12272-012-0501-4] [PMID:  22644843] 
[288] 
Tepale MRG, Reyes L, Flores MM, et al. Cyclopurpuracin, a cyclopeptide from Annona purpurea seeds. Phytochem Lett  2018; 23: 164-7.
[http://dx.doi.org/10.1016/j.phytol.2017.12.008] 
[289] 
Pacheco FC, Alfaro GV, Luna DS, Fernández JJ. Sclerin, a New Cytotoxic Cyclononapeptide from Annona scleroderma. Molecules  2019; 24(3): 1-8.
[PMID:  30678271] 
[290] 
Wu P, Wu M, Xu L, Xie H, Wei X. Anti-inflammatory cyclopeptides from exocarps of sugar-apples. Food Chem  2014; 152: 23-8.
[http://dx.doi.org/10.1016/j.foodchem.2013.11.100] [PMID:  24444902] 
[291] 
Chen Y, Chen JW, Wang Y, Xu SS, Li X. Six cytotoxic annonaceous acetogenins from Annona squamosa seeds. Food Chem  2012; 135(3): 960-6.
[http://dx.doi.org/10.1016/j.foodchem.2012.05.041] [PMID:  22953811] 
[292] 
Jayendra Y, Kumar Y, Kumar SS. Two new tetrahydroisoquinoline analogs from Indian medicinal plant Annona squamosa. J Pharm Res  2013; 7: 510-5.
[http://dx.doi.org/10.1016/j.jopr.2013.06.022] 
[293] 
Ma C, Wang Q, Shi Y, et al. Three new antitumor annonaceous acetogenins from the seeds of Annona squamosa. Nat Prod Res  2017; 31(18): 2085-90.
[http://dx.doi.org/10.1080/14786419.2016.1274897] [PMID:  28064519] 
[294] 
Chen Y, Chen JW, Li X. Cytotoxic bistetrahydrofuran annonaceous acetogenins from the seeds of Annona squamosa. J Nat Prod  2011; 74(11): 2477-81.
[http://dx.doi.org/10.1021/np200708q] [PMID:  22011319] 
[295] 
Agu KC, Okolie NP, Falodun A, Lutz NE. In vitro anticancer assessments of Annona muricata fractions and in vitro antioxidant profile of fractions and isolated acetogenin (15-acetyl guanacone). J Cancer Res Pract  2018; 5: 53-66.
[http://dx.doi.org/10.1016/j.jcrpr.2017.12.001] 
[296] 
Chen YY, Cao YZ, Li FQ, et al. Studies on anti-hepatoma activity of Annona squamosa L. pericarp extract. Bioorg Med Chem Lett  2017; 27(9): 1907-10.
[http://dx.doi.org/10.1016/j.bmcl.2017.03.036] [PMID:  28351591] 
[297] 
Yang RM, Li WM, Hu WJ, et al. Anticancer effect of total annonaceous acetogenins on hepatocarcinoma. Chin J Integr Med  2015; 21(9): 682-8.
[http://dx.doi.org/10.1007/s11655-014-1845-z] [PMID:  24938450] 
[298] 
Costa EV, da Cruz PE, de Lourenço CC, de Souza Moraes VR, de Lima Nogueira PC, Salvador MJ. Antioxidant and antimicrobial activities of aporphinoids and other alkaloids from the bark of Annona salzmannii A. DC. (Annonaceae). Nat Prod Res  2013; 27(11): 1002-6.
[http://dx.doi.org/10.1080/14786419.2012.688044] [PMID:  22582985] 
[299] 
Parellada EA, Ramos NA, Ferrero M, Cartagena E, Bardón A, Neske A. Effect of the annonaceous acetogenins, squamocin and laherradurin, on the degradation of naphthalene mediated by Pseudomonas plecoglossicida J26. Int Biodeterior Biodegradation  2012; 72: 82-7.
[http://dx.doi.org/10.1016/j.ibiod.2012.05.015] 
[300] 
Okoye TC, Akah PA, Okoli CO, Ezike AC, Omeje EO, Odoh UE. Antimicrobial Effects of a Lipophilic Fraction and Kaurenoic Acid Isolated from the Root Bark Extracts of Annona senegalensis. Evid Based Complement Alternat Med 2012.2012831327
[http://dx.doi.org/10.1155/2012/831327] [PMID:  22675389] 
[301] 
Justino AB, Miranda NC, Franco RR, Martins MM, Silva NMD, Espindola FS. Annona muricata Linn. leaf as a source of antioxidant compounds with in vitro antidiabetic and inhibitory potential against α-amylase, α-glucosidase, lipase, non-enzymatic glycation and lipid peroxidation. Biomed Pharmacother  2018; 100: 83-92.
[http://dx.doi.org/10.1016/j.biopha.2018.01.172] [PMID:  29425747] 
[302] 
Florence NT, Benoit MZ, Jonas K, et al. Antidiabetic and antioxidant effects of Annona muricata (Annonaceae), aqueous extract on streptozotocin-induced diabetic rats. J Ethnopharmacol  2014; 151(2): 784-90.
[http://dx.doi.org/10.1016/j.jep.2013.09.021] [PMID:  24076471] 
[303] 
Ansante TF, Ribeiro LP, Bicalho KU, et al. Secondary metabolites from Neotropical Annonaceae: Screening, bioguided fractionation, and toxicity to Spodoptera frugiperda (J.E.Smith) (Lepidoptera: Noctuidae). Ind Crops Prod  2015; 74: 969-76.
[http://dx.doi.org/10.1016/j.indcrop.2015.05.058] 
[304] 
Matsumoto S, Varela RM, Palma M, et al. Bio-guided optimization of the ultrasound-assisted extraction of compounds from Annona glabra L. leaves using the etiolated wheat coleoptile bioassay. Ultrason Sonochem  2014; 21(4): 1578-84.
[http://dx.doi.org/10.1016/j.ultsonch.2014.01.024] [PMID:  24556321] 
[305] 
Okoye TC, Akah PA, Omeje EO, Okoye FBC, Nworu CS. Anticonvulsant effect of kaurenoic acid isolated from the root bark of Annona senegalensis. Pharmacol Biochem Behav  2013; 109: 38-43.
[http://dx.doi.org/10.1016/j.pbb.2013.05.001] [PMID:  23664900] 
[306] 
Rejón-Orantes Jdel C, González-Esquinca AR, de la Mora MP, Roldan Roldan G, Cortes D. Annomontine, an alkaloid isolated from Annona purpurea, has anxiolytic-like effects in the elevated plus-maze. Planta Med  2011; 77(4): 322-7.
[http://dx.doi.org/10.1055/s-0030-1250406] [PMID:  20890807] 
[307] 
Chavan MJ, Wakte PS, Shinde DB. Analgesic and anti-inflammatory activities of 18-acetoxy-ent-kaur-16-ene from Annona squamosa L. bark. Inflammopharmacology  2011; 19(2): 111-5.
[http://dx.doi.org/10.1007/s10787-010-0061-5] [PMID:  20957519] 
[308] 
Sánchez G, Estrada O, Acha G, et al. The norpurpureine alkaloid from Annona purpurea inhibits human platelet activation in vitro. Cell Mol Biol Lett  2018; 23(1): 15.
[http://dx.doi.org/10.1186/s11658-018-0082-4] [PMID:  29713353] 
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DOI https://dx.doi.org/10.2174/1381612826666200325094422	Print ISSN 1381-6128
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Current Pharmaceutical Design

Annona Genus: Traditional Uses, Phytochemistry and Biological Activities

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