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Review Article

在工作场所中呼出的一氧化氮分数和纳米材料暴露

卷 27, 期 42, 2020

页: [7200 - 7212] 页: 13

弟呕挨: 10.2174/0929867327666200320154545

价格: $65

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摘要

背景：工程纳米材料（ENM）的广泛应用以及一般和职业暴露的可能性越来越大，这引起了人们对其可能对人类健康的影响的担忧。实际上，ENMs可能会引起不同器官系统的变化，尤其是呼吸道的变化。因此，重要的是要确定暴露工人早期肺部影响的可能生物标志物。在这方面，在生物监测中使用呼出一氧化氮的分数（FENO）的可能性引起了极大的兴趣。 目的：全面评估FENO作为ENM暴露工人肺部疾病可能的生物标志物的作用。 方法：根据PRISMA指南，对Pubmed，Scopus和ISI Web of Knowledge数据库进行了系统的搜索。 结果：七项研究调查了暴露于不同种类的金属（即银和金），金属氧化物（钛和二氧化硅）和碳基ENM（碳纳米管）的工人的FENO。通常，在暴露的工人和对照之间没有发现明显的改变。 结论：由于可用的研究数量有限且被调查的人群较小，因此无法推断出FENO在职业生物学监测中的功能的确切结论。另外，缺乏环境监测数据和对ENM作用模式的零碎知识阻碍了建立剂量-反应关系。考虑到可能的职业暴露问题（即特征不同的ENM和工作任务以及个体影响因素（例如吸烟和特应性）），未来的研究似乎有必要深入定义将FENO用作肺部疾病早期生物标志物的可能性。

关键词: 呼出气一氧化氮，纳米材料，纳米颗粒，生物标志物，呼出气冷凝物，职业暴露。

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