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当代阿耳茨海默病研究

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ISSN (Print): 1567-2050
ISSN (Online): 1875-5828

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Meta-Analysis

ALDH2基因多态性与迟发性阿尔茨海默病之间的关联：最新的荟萃分析

卷 17, 期 2, 2020

页: [105 - 111] 页: 7

弟呕挨: 10.2174/1567205017666200317102337

价格: $65

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摘要

目的：先前的病例对照研究集中于ALDH2基因多态性与迟发性阿尔茨海默氏病（LOAD）的关系，但尚未得出明确的统一结论。因此，ALDH2 Glu504Lys多态性与LOAD之间的相关性仍存在争议。为了分析ALDH2多态性与LOAD风险之间的相关性，我们实施了这一最新的荟萃分析以评估可能的关联。 方法：从1994年1月1日至2018年12月31日通过中国国家知识基础设施（CNKI），中国技术期刊VIP数据库，中国生物医学，PubMed，Cochrane图书馆，ClinicalTrials.gov，Embase和MEDLINE搜索研究。 ，对语言和种族没有任何限制。 结果：5项针对1057例LOAD患者和1136例健康对照的研究符合我们的分析标准。从统计学上讲，ALDH2 GA / AA基因型与增加LOAD风险无关（优势比（OR）= 1.48，95％置信区间（CI）= 0.96-2.28，p = 0.07）。在亚组分析中，观察到ALDH2 * 2男性有更高的患病风险（OR = 1.72，95％CI = 1.10-2.67，p = 0.02）。 结论：本研究仅包括五项现有的病例对照研究，结果为阴性。当样本数量扩大时，可能会出现正趋势。将来，应进行更大规模的病例对照或队列研究，以增强ALDH2多态性与AD或其他神经退行性疾病之间的联系。

关键词: 阿尔茨海默病，ALDH2，基因多态性，病例对照研究，最新荟萃分析。

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