The Use of Polymer-Bound Triphenylphosphine in the Stereochemical Inversion of Secondary Alcohols

Title: The Use of Polymer-Bound Triphenylphosphine in the Stereochemical Inversion of Secondary Alcohols

Volume: 3 Issue: 2

Author(s): J. M. White, A. R. Tunoori, D. Dutta and G. I. Georg

Affiliation:

Keywords: Polymer bound triphenylphosphine, Mitsunobu reaction, Diethyl azodicarboxylate, Lithium hydroxide, Tetrahydrofuran

Abstract: Polymer-bound triphenylphosphine can replace triphenylphosphine in the Mitsunobu reaction to generate stereochemically inverted secondary alcohols. This method is comparable with the standard Mitsunobu reaction in terms of inversion of stereochemistry, yield, and reaction time, even for sterically very hindered secondary alcohols. The special merit of this reaction is that the excess polymer-bound triphenylphosphine and its by-products are easily removed by filtration from the reaction products.

Cite this article as:

White M. J., Tunoori R. A., Dutta D. and Georg I. G., The Use of Polymer-Bound Triphenylphosphine in the Stereochemical Inversion of Secondary Alcohols, Combinatorial Chemistry & High Throughput Screening 2000; 3 (2) . https://dx.doi.org/10.2174/1386207003331706

DOI https://dx.doi.org/10.2174/1386207003331706	Print ISSN 1386-2073
Publisher Name Bentham Science Publisher	Online ISSN 1875-5402