Abstract
The current surge in parallel array synthesis for the production of small molecule libraries has generated keen interest in the application of solid-supported reagents and catalysts in solution-phase chemistry. The strategy assimilates the advantages of product isolation and purification of solid-phase organic synthesis with the flexible choice of chemistry from the vast repertoire of solution-phase organic reactions. This review summarizes the significant recent advances in the application of polymer-bound reagents and catalysts in solution-phase synthesis of organic molecules. Multi-step reaction sequences employing sequential use of polymer-supported reagents are also discussed. In view of the earlier review publications on this topic, only the recent literature covering 1998 and 1999 is included.
Keywords: Polymer supported reagents, Catalysts, Synthetic application, Solution phase organic reaction, Polymer bound reagents, Mitsunobu reaction, Horner emmons reaction, Polymer bound atalysts, Nafion membrane catalysis, Resin bound cobalt II catalyst
Combinatorial Chemistry & High Throughput Screening
Title: Polymer-Supported Reagents and Catalysts Recent Advances in Synthetic Applications
Volume: 3 Issue: 2
Author(s): Sukanta Bhattacharyya
Affiliation:
Keywords: Polymer supported reagents, Catalysts, Synthetic application, Solution phase organic reaction, Polymer bound reagents, Mitsunobu reaction, Horner emmons reaction, Polymer bound atalysts, Nafion membrane catalysis, Resin bound cobalt II catalyst
Abstract: The current surge in parallel array synthesis for the production of small molecule libraries has generated keen interest in the application of solid-supported reagents and catalysts in solution-phase chemistry. The strategy assimilates the advantages of product isolation and purification of solid-phase organic synthesis with the flexible choice of chemistry from the vast repertoire of solution-phase organic reactions. This review summarizes the significant recent advances in the application of polymer-bound reagents and catalysts in solution-phase synthesis of organic molecules. Multi-step reaction sequences employing sequential use of polymer-supported reagents are also discussed. In view of the earlier review publications on this topic, only the recent literature covering 1998 and 1999 is included.
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Cite this article as:
Bhattacharyya Sukanta, Polymer-Supported Reagents and Catalysts Recent Advances in Synthetic Applications, Combinatorial Chemistry & High Throughput Screening 2000; 3 (2) . https://dx.doi.org/10.2174/1386207003331751
DOI https://dx.doi.org/10.2174/1386207003331751 |
Print ISSN 1386-2073 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5402 |
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