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General Review Article

肾细胞癌的免疫治疗和放射治疗

卷 21, 期 14, 2020

页: [1463 - 1475] 页: 13

弟呕挨: 10.2174/1389450121666200311121540

价格: $65

摘要

背景：肾细胞癌的治疗和免疫治疗正在迅速发展，主要包括免疫检查点抑制剂，是转移患者的治疗方案的革命性。新的放射治疗分割时间表，包括高剂量的小部分，可以克服该肿瘤的放射抵抗。局部放射治疗与全身性效应有关，即所谓的戒酒效应。放疗与免疫治疗结合可增强免疫系统介导的这种作用。 目的：在这篇综述中，我们探讨了放射治疗和免疫治疗在肾细胞癌中的作用，结合这些策略的基本原理，以及正在进行的研究这两种治疗模式组合的临床试验。 结论：免疫治疗和放射治疗的结合具有很强的理论基础和临床前研究的支持，因为它可以克服肿瘤微环境的免疫抑制，增加抗肿瘤免疫反应。需要从临床试验中获得更多的临床证据，以证明这些治疗联合使用的有效性和安全性。

关键词: 肾细胞癌，放射治疗，免疫治疗，异位效应，免疫检查点抑制剂，PD-1/PD-L1抑制剂

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