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Review Article

吲哚衍生物的药物学观点：最新进展和结构-活性关系研究

卷 21, 期 9, 2020

页: [864 - 891] 页: 28

弟呕挨: 10.2174/1389450121666200310115327

价格: $65

摘要

杂环化合物在人体的各种生物学过程中起着重要作用，并且由于它们的多样化，化学和生物学特性，它们中的许多已在临床上使用。其中，吲哚是最有前途的药理活性分子之一。由于其化学反应性，吲哚已被随意修饰以获得各种新的先导分子，这些新的先导分子已成功地用于获得用于治疗不同药理学疾病的新候选药物。长春新碱（抗癌药），利血平（抗高血压药），阿美达林（抗抑郁药）等吲哚类化合物描述了吲哚在提升人类生活中的医学和药理重要性。在这篇评论中，我们收集了有关吲哚衍生物及其生物学意义的各种报告，包括从2015年开始的抗真菌药，抗原生动物药，抗血小板药，抗阿尔茨海默氏病，抗帕金森病，抗氧化剂和抗癌药。另外，还包括对不同衍生物的构效关系的研究。我们还讨论了在此期间开发的用于合成不同的吲哚衍生物的新颖合成策略。我们相信这篇综述文章将提供有关吲哚的医学重要性的全面知识，并将有助于设计和合成具有高效力和功效的新型基于吲哚的分子。

关键词: 吲哚衍生物，抗真菌，抗原生动物，抗阿尔茨海默病，抗帕金森病，合成策略。

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