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Current Neuropharmacology

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ISSN (Print): 1570-159X
ISSN (Online): 1875-6190

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Review Article

The e-Psychonauts’ ‘Spiced’ World; Assessment of the Synthetic Cannabinoids’ Information Available Online

Author(s): Caroline Zangani, Fabrizio Schifano*, Flavia Napoletano, Davide Arillotta, Liam Gilgar, Amira Guirguis, John M. Corkery, Orsola Gambini and Alessandro Vento

Volume 18, Issue 10, 2020

Page: [966 - 1051] Pages: 86

DOI: 10.2174/1570159X18666200302125146

Price: $65

Abstract

Background: A wide range of novel psychoactive substances (NPS) is regularly searched and discussed online by web-based drug enthusiasts (i.e. the e-psychonauts). Among NPS, the range of synthetic cannabinoids (SC; ‘Spice’) currently represents a challenge for governments and clinicians.

Methods: Using a web crawler (i.e. the NPS.Finder®), the present study aimed at assessing psychonauts’ fora/platforms to better understand the online mentions of SC.

Results: The open-web crawling/navigating software identified here some 1,103 synthetic cannabinoids. Of these, 863 molecules were not listed in either the international or the European NPS databases.

Conclusion: A web crawling approach helped here in identifying a large range of unknown SC likely to possess a misuse potential. Most of these novel/emerging molecules are still relatively unknown. This is a reason for concern; each of these analogues potentially presents different toxicodynamic profiles and there is a lack of docking, preclinical, and clinical observations. Strengthening multidisciplinary collaboration between clinicians and bioinformatics may prove useful in better assessing SC-associated public health risks.

Keywords: Psychonauts, NPS, new psychoactive substances, synthetic cannabinoids, web crawling.

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Graphical Abstract

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