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Review Article

子宫内膜异位症中异常DNA甲基化和靶向DNA甲基转移酶的表观遗传药物的综述

卷 21, 期 11, 2020

页: [1047 - 1055] 页: 9

弟呕挨: 10.2174/1389450121666200228112344

价格: $65

摘要

背景：子宫内膜异位症(EMS)是一种妇科疾病，是指子宫内膜组织在子宫外其他组织或器官中的移位和生长。临床表现为痛经、月经不调，甚至不孕。EMS虽然是一种良性疾病，但它具有恶性肿瘤的特点和恶性转化的潜力。近年来的研究发现，EMS可能涉及表观遗传变化，各种表观遗传异常，特别是异常的DNA甲基化可能在EMS的发病机制中发挥重要作用。先前的研究已经阐明了EMS的表观遗传调控因子，并报道了与EMS异常的激素、免疫和炎症状态相关的基因表观遗传模式的变化。随着高通量测序和其他生物分子技术的发展，我们对EMS全基因组甲基化有了更好的理解。目的:本文将讨论靶向DNA甲基化治疗EMS的可能性。 结果：本文综述了DNA甲基化在EMS病理生理学中的作用，并通过靶向DNA甲基化修饰剂为EMS提供了一种新的治疗方法。我们还回顾了目前在EMS治疗中使用DNA甲基化抑制剂的进展，以及未来潜在的前景和挑战。 结论：异常的DNA甲基化在EMS的发病机制中起着至关重要的作用，靶向DNA甲基转移酶的表观遗传药物有望成为EMS新治疗的理论基础。

关键词: 子宫内膜异位症，异常DNA甲基化，基因，通路，DNMTs

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