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Current Organic Chemistry

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ISSN (Online): 1875-5348

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Review Article

Recent Developments on the Synthesis of Biologically Significant bis/tris(indolyl)methanes under Various Reaction Conditions: A Review

Author(s): Arvind Singh, Gurpreet Kaur and Bubun Banerjee*

Volume 24, Issue 6, 2020

Page: [583 - 621] Pages: 39

DOI: 10.2174/1385272824666200228092752

Price: $65

Abstract

Bis(indolyl)methane skeleton is the main building block of many naturally occurring bioactive compounds. Bis(indolyl)methanes are found to possess a wide range of pharmaceuitical efficacies. These important scaffolds are being used as anti-cancer, antioxidant, anti-bacterial, anti-inflammatory, and anti-proliferative agents. In this review, we summarized the latest developments on the synthesis of various bis/tris(indolyl)methane derivatives from the reactions of two equivalents of indoles and one equivalent of aldehydes or indole-3-carbaldehydes under various reaction conditions. More than hundred different catalysts were employed for these transformations which include various metal catalysts, ionic liquids, organocatalysts, surfactants, homogeneous, heterogeneous catalysts etc.

Keywords: Bis(indolyl)methanes, tris(indolyl)methanes, homogeneous catalysts, heterogeneous catalysts, biological activities, indole-3- carbaldehydes.

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