摘要
背景:甘丙肽(GAL)构成由四个肽组成的神经肽家族:(i)甘丙肽(GAL),(ii)甘丙肽相关肽(GAMP),(iii)甘丙肽样肽(GALP)和(iv )阿拉林。 GAL包含29/30个氨基酸,其生物学作用是通过与其各种受体(GALR1,GALR2和GALR3)的相互作用而发生的。神经肽GAL调节中枢神经系统,周围神经系统和周围器官的几种生理和病理生理功能。 GAL主要由少突胶质细胞,星形胶质细胞和胃肠道分泌,其作用取决于与其不同受体的相互作用。这些受体主要在中枢,周围神经系统和肠中表达。 目的:本综述评估GAL家族在炎性疾病中的作用。由于不同细胞类型中GAL和GALR之间的相互作用,对信号传导和药理作用进行了概述。批判性地讨论了GAL作为治疗资源的潜在用途。 结论:建议GAL在某些情况下具有抗炎功能,而在另一些情况下具有促炎功能。关于GAL的文献是有争议的,目前尚无定论。这可能是由于GAL和GALR之间的相互作用引起的代谢网络信号传递的复杂性。在未来的将来,GAL可能会成为多种疾病的有希望的治疗资源,但是目前不建议将其用于疾病控制。
关键词: 甘丙肽,信号传导,专利,神经肽,促炎,抗炎。
图形摘要
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