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Review Article

阿尔茨海默氏病的一种即将来临的方法：植物生物活性分子的民族药理学潜力

卷 27, 期 26, 2020

页: [4344 - 4371] 页: 28

弟呕挨: 10.2174/0929867327666200219120806

价格: $65

摘要

背景：神经退行性疾病在过去的几十年中已达到流行水平。不仅老年人，而且成年人也越来越受到影响。在这些疾病中，阿尔茨海默氏病是最普遍和最严重的疾病之一，与多种疾病和依赖性发病率高相关。尽管存在多种用于对症治疗的药物，但它们除了疗效有限外，还具有一些副作用和毒性。植物制剂具有长期用途，被广泛推荐用于多种目的，例如用于改善脑部健康。目的：本报告的目的是使对植物食品衍生的具有积极的体外酶抑制活性的生物活性分子的知识系统化。结果：生物碱，酚类化合物和萜烯是研究最多的植物化学物质，均来自天然和商业来源。尽管它们作为酶抑制剂具有有效的活性，但体内研究甚至临床试验的数量已证实其真正的生物活性潜力仍然稀缺。结论：因此，一旦这些相关的信息工具能够为阿尔茨海默氏病治疗领域的有希望的进步做出重大贡献，加深这一领域的知识就至关重要。

关键词: 神经退行性疾病，阿尔茨海默氏病，植物化学物质，生物活性分子，体外研究，酶促抑制活性。

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