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当代阿耳茨海默病研究

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ISSN (Print): 1567-2050
ISSN (Online): 1875-5828

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Research Article

雄性5xFAD Alzheimer模型小鼠的睾丸激素水平和尿液气味标记升高

卷 17, 期 1, 2020

页: [80 - 92] 页: 13

弟呕挨: 10.2174/1567205017666200217105537

价格: $65

摘要

背景：淀粉样前体蛋白（AβPP）及其各种裂解产物的功能仍未阐明。尽管它在阿尔茨海默氏病（AD）中作为神经毒性淀粉样蛋白（Aβ）肽的来源的作用是无可争议的，并且它作为细胞附着蛋白的特性令人着迷，但几乎没有研究神经元以外的功能。这尤其值得注意，因为AβPP具有普遍的表达特征，并且其较长的同种型AβPP750和770在脑外和非神经元细胞的各种组织中发现。 目的：在这里，我们旨在分析与男性性功能有关的5xFAD阿尔茨海默氏病小鼠模型。该小鼠模型的转基因受Thy1启动子活性调节，并且Thy1在睾丸中表达，例如在睾丸中。通过支持细胞。这允许推测对性行为的影响。 方法：我们分析了5xFAD小鼠和野生型同窝仔的睾丸组织的形态和生化特性以及血清，睾丸和大脑中的睾丸激素水平。两组通过不同年龄的尿液气味标记测试来评估性行为。结果：虽然精子数量，睾丸重量和精子形态表型与野生型同窝小鼠几乎没有区别，但AD模型小鼠的睾丸睾丸激素水平显着增加。如尿气味标记测试所示，这伴随着性兴趣的提高和延长。 结论：我们建议，AβPP的过表达（通常用于模拟模型小鼠的AD）也会影响男性的性行为，如通过尿液气味标记（USM）测试进行的其他评估。睾丸激素水平升高可能会对中枢神经系统雄激素受体产生额外影响，并且在评估学习和记忆能力时也必须予以考虑。

关键词: 阿尔茨海默氏病，淀粉样蛋白前体蛋白，小鼠，性行为，睾丸激素，尿液气味标记试验。

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