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Current Organic Chemistry

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ISSN (Online): 1875-5348

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Review Article

Tetrazoloquinolines: Synthesis, Reactions, and Applications

Author(s): Rizk E. Khidre*, Tahah A. Ameen and Mounir A. I. Salem

Volume 24, Issue 4, 2020

Page: [439 - 464] Pages: 26

DOI: 10.2174/1385272824666200217095341

Price: $65

Abstract

This review summarizes the synthesis, reactions, and biological activities of tetrazolo[1,5-a]quinoline derivatives. These derivatives were synthesized by several methods such as i) from the reaction of 2-chloroquinoline with sodium azide ii) from diazotization 2-hydrazinylquinoline derivatives, and iii) from intramolecular cyclocondensation of 2-azidoarylidenes. Also, the chemical reactions and pharmacological activities of some tetrazoloquinolines such as tetrazolo[1,5-a]quinoline-4-carbaldehyde, 5-chlorotetrazolo[ 1,5-a]quinoline, 4-(chloromethyl)tetrazolo[1,5-a]quinoline, tetrazolo[1,5- a]quinoline-4-carboxylic acid, and 5-azidotetrazolo[1,5-a]quinoline were discussed.

Keywords: Quinoline, tetrazoloquinoline, pyrimidine, pyrazole, heterocycles, pharmacological activities.

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