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Review Article

n6 -甲基腺嘌呤RNA修饰(m6A):一种新兴的代谢性疾病调节因子

卷 21, 期 11, 2020

页: [1056 - 1067] 页: 12

弟呕挨: 10.2174/1389450121666200210125247

价格: $65

摘要

n6 -甲基腺嘌呤RNA修饰(m6A)是由甲基转移酶催化在腺嘌呤(A)第6位氮原子上进行的RNA甲基化修饰，是真核生物信使RNA (mRNA)最常见的化学修饰。近年来，人们发现m6A在RNA的动态调控中发挥重要作用，而RNA在脂肪形成、细胞分化、免疫/炎症反应等生理病理生理过程中起着至关重要的作用。代谢性疾病是由蛋白质、葡萄糖、脂类代谢紊乱引起的一系列慢性炎症性疾病。新兴研究表明，m6A通过调节糖/脂代谢和免疫/炎症反应，在肥胖、2型糖尿病(T2DM)和心血管疾病(CVDs)等代谢性疾病过程中发挥重要作用。本文将对m6A在代谢性疾病中的作用进行综述，以期为代谢性疾病的防治提供新的思路。

关键词: 腺嘌呤甲基化，代谢性疾病，肥胖，2型糖尿病，心血管疾

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图形摘要

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