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Review Article

现有抗疟药概述:发现、作用模式和耐药性

卷 20, 期 8, 2020

页: [583 - 592] 页: 10

弟呕挨: 10.2174/1566524020666200207123253

价格: $65

摘要

疟疾是世界上最致命的三种传染病之一，严重危害人类健康和生命。为了减轻这一疾病的公共卫生负担，科学家将重点放在发现和开发有效的抗疟药物上，从奎宁和氯喹到抗叶酸和青蒿素及其衍生物，这些药物都在治疗疟疾方面发挥着深远的作用。然而，由于频繁使用抗疟药物，恶性疟原虫耐药菌株出现，并对现有抗疟药物产生越来越多的耐药性，在世界上造成了灾难性的后果。特别是，2008年报告的青蒿素耐药性是最令人关切的问题。对青蒿素的耐药性一直是疟疾控制的主要障碍，目前遏制青蒿素耐药性的努力尚未取得成功。基于目前的形势，迫切需要开发更有效的新型抗疟药，其靶标与世界上传统抗疟药不同，从而有助于最大限度地减少耐药性现象。本文就不同种类的抗疟药物的治疗效果、作用机制和耐药性进行综述，并提出新的解决方案，以期进一步提高疟疾的消灭水平。

关键词: 疟疾，抗疟药，恶性疟原虫，作用机制，耐药性，青蒿素。

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