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Review Article

神经内分泌肿瘤的临床和转化研究挑战

卷 27, 期 29, 2020

页: [4823 - 4839] 页: 17

弟呕挨: 10.2174/0929867327666200207120725

open access plus

摘要

神经内分泌肿瘤（NETs）代表了一系列肿瘤，这些肿瘤可能源于人体任何部位的任何（神经）内分泌细胞。 与任何其他罕见疾病一样，NET在研究方面也面临一些困难。 这篇综述将描述具有罕见恶性肿瘤专业知识的研究人员面临的一些主要挑战和建议的解决方案。 本文概述了临床和转化研究中的一些最常见挑战，涵盖了临床，转化和基础研究的各个方面。 NET是一种异质性疾病，临床和转化研究项目的样本量有限是主要挑战。 NET的挑战在于解决罕见疾病的医疗模式之间的差异。 由于大量不同的实体，NET增加了一层额外的复杂性。 随着电子医疗技术的革命，前瞻性的现实世界数据试验为罕见癌症提供了机会。 这篇综述探讨了应对这些挑战的潜在解决方案，这些解决方案不仅对NET社区有用，而且对其他稀有肿瘤研究人员也很有用。

关键词: 神经内分泌肿瘤，肿瘤，前肠，中肠，后肠，转化研究。

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