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Review Article

了解基于质谱的全球性分枝杆菌脂质组学

卷 20, 期 8, 2020

页: [607 - 623] 页: 17

弟呕挨: 10.2174/1566524020666200206120840

价格: $65

摘要

结核病(TB)是单一感染因子结核分枝杆菌(MTB)死亡的首要原因。目前的治疗方案存在几个问题，包括副作用、费用和出现多药耐药(MDR)。此外，传统的诊断方法要么太慢，要么缺乏准确和强大的生物标志物。在这种情况下，以快速代谢物为基础的生物标志物作为新的药物靶点可能是规避MDR的一种潜在方法。在“组学”科学时代，脂质组学因揭示富含脂质的分枝杆菌物种的复杂性而备受关注。脂质组学是代谢组学的一个分支，代谢产物之间的原子结构具有极大的多样性。不同于其他生物分子，如核酸、蛋白质或碳水化合物，代谢物的多样性并没有单一的定义原则。MTB编码10%的基因组进行脂质代谢，脂质占其干重的60%。分枝杆菌拥有广泛的脂质储备光谱，从高度非极性脂质到高度极性脂质，增加了鉴定和分析的复杂性。与靶向方法相比，MTB的非靶向或全局脂质组学仍然更具挑战性。本文综述了脂质组学技术在色谱、检测方法和评价现有基于质谱的脂质组学工具方面的最新进展，以研究非靶向或全局MTB脂质组学。它还确定了现有技术的局限性，并探索了建立MTB脂质体同时面临的实际挑战的解决方案。我们一致认为，新兴的脂质组学工具为理解脂质分子在MTB发病机制中的作用以及进一步改进的必要性提供了更广阔的视野。

关键词: 结核病，脂质，LCMS，薄层色谱，脂质数据库，脂质组学。

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