Login Register Cart 0
Generic placeholder image

Current Pharmaceutical Design

Editor-in-Chief

ISSN (Print): 1381-6128
ISSN (Online): 1873-4286

Back
Journal Home About Journal Editorial Board Journal Insight Current Issue Volumes/Issues
Subscribe
Mini-Review Article

Modulatory Effects of Food Restriction on Brain and Behavioral Effects of Abused Drugs

Author(s): Kenneth D. Carr*

Volume 26, Issue 20, 2020

Page: [2363 - 2371] Pages: 9

DOI: 10.2174/1381612826666200204141057

Price: $65

Abstract

Energy homeostasis is achieved, in part, by metabolic signals that regulate the incentive motivating effects of food and its cues, thereby driving or curtailing procurement and consumption. The neural underpinnings of these regulated incentive effects have been identified as elements within the mesolimbic dopamine pathway. A separate line of research has shown that most drugs with abuse liability increase dopamine transmission in this same pathway and thereby reinforce self-administration. Consequently, one might expect shifts in energy balance and metabolic signaling to impact drug abuse risk. Basic science studies have yielded numerous examples of drug responses altered by diet manipulation. Considering the prevalence of weight loss dieting in Western societies, and the anorexigenic effects of many abused drugs themselves, we have focused on the CNS and behavioral effects of food restriction in rats. Food restriction has been shown to increase the reward magnitude of diverse drugs of abuse, and these effects have been attributed to neuroadaptations in the dopamine-innervated nucleus accumbens. The changes induced by food restriction include synaptic incorporation of calcium-permeable AMPA receptors and increased signaling downstream of D1 dopamine receptor stimulation. Recent studies suggest a mechanistic model in which concurrent stimulation of D1 and GluA2-lacking AMPA receptors enables increased stimulus-induced trafficking of GluA1/GluA2 AMPARs into the postsynaptic density, thereby increasing the incentive effects of food, drugs, and associated cues. In addition, the established role of AMPA receptor trafficking in enduring synaptic plasticity prompts speculation that drug use during food restriction may more strongly ingrain behavior relative to similar use under free-feeding conditions.

Keywords: Reward, nucleus accumbens, food restriction, AMPA receptors, dopamine, addiction.

« Previous Next »
[1]
DeSousa NJ, Bush DE, Vaccarino FJ. Self-administration of intravenous amphetamine is predicted by individual differences in sucrose feeding in rats. Psychopharmacology (Berl) 2000; 148(1): 52-8.
[http://dx.doi.org/10.1007/s002130050024] [PMID: 10663417]
[2]
Radke AK, Zlebnik NE, Holtz NA, Carroll ME. Cocaine-induced reward enhancement measured with intracranial self-stimulation in rats bred for low versus high saccharin intake. Behav Pharmacol 2016; 27(2-3 Spec Issue): 133-6.
[http://dx.doi.org/10.1097/FBP.0000000000000182] [PMID: 26292189]
[3]
Avena NM, Hoebel BG. A diet promoting sugar dependency causes behavioral cross-sensitization to a low dose of amphetamine. Neuroscience 2003; 122(1): 17-20.
[http://dx.doi.org/10.1016/S0306-4522(03)00502-5] [PMID: 14596845]
[4]
Gosnell BA. Sucrose intake enhances behavioral sensitization produced by cocaine. Brain Res 2005; 1031(2): 194-201.
[http://dx.doi.org/10.1016/j.brainres.2004.10.037] [PMID: 15649444]
[5]
Vollbrecht PJ, Nobile CW, Chadderdon AM, Jutkiewicz EM, Ferrario CR. Pre-existing differences in motivation for food and sensitivity to cocaine-induced locomotion in obesity-prone rats. Physiol Behav 2015; 152(Pt A): 151-60.
[http://dx.doi.org/10.1016/j.physbeh.2015.09.022] [PMID: 26423787]
[6]
Cabeza de Vaca S, Carr KD. Food restriction enhances the central rewarding effect of abused drugs. J Neurosci 1998; 18(18): 7502-10.
[http://dx.doi.org/10.1523/JNEUROSCI.18-18-07502.1998] [PMID: 9736668]
[7]
Wellman PJ, Nation JR, Davis KW. Impairment of acquisition of cocaine self-administration in rats maintained on a high-fat diet. Pharmacol Biochem Behav 2007; 88(1): 89-93.
[http://dx.doi.org/10.1016/j.pbb.2007.07.008] [PMID: 17764729]
[8]
Teegarden SL, Nestler EJ, Bale TL. Delta FosB-mediated alterations in dopamine signaling are normalized by a palatable high-fat diet. Biol Psychiatry 2008; 64(11): 941-50.
[http://dx.doi.org/10.1016/j.biopsych.2008.06.007] [PMID: 18657800]
[9]
Sharma S, Fernandes MF, Fulton S. Adaptations in brain reward circuitry underlie palatable food cravings and anxiety induced by high-fat diet withdrawal. Int J Obes 2013; 37(9): 1183-91.
[http://dx.doi.org/10.1038/ijo.2012.197] [PMID: 23229740]
[10]
Kenny PJ. Common cellular and molecular mechanisms in obesity and drug addiction. Nat Rev Neurosci 2011; 12(11): 638-51.
[http://dx.doi.org/10.1038/nrn3105] [PMID: 22011680]
[11]
Volkow ND, Wang G-J, Fowler JS, Telang F. Overlapping neuronal circuits in addiction and obesity: evidence of systems pathology. Philos Trans R Soc Lond B Biol Sci 2008; 363(1507): 3191-200.
[http://dx.doi.org/10.1098/rstb.2008.0107] [PMID: 18640912]
[12]
Wang GJ, Volkow ND, Thanos PK, Fowler JS. Similarity between obesity and drug addiction as assessed by neurofunctional imaging: a concept review. J Addict Dis 2004; 23(3): 39-53.
[http://dx.doi.org/10.1300/J069v23n03_04] [PMID: 15256343]
[13]
Fletcher PC, Kenny PJ. Food addiction: a valid concept? Neuropsychopharmacology 2018; 43(13): 2506-13.
[http://dx.doi.org/10.1038/s41386-018-0203-9] [PMID: 30188514]
[14]
Opland DM, Leinninger GM, Myers MG Jr. Modulation of the mesolimbic dopamine system by leptin. Brain Res 2010; 1350: 65-70.
[http://dx.doi.org/10.1016/j.brainres.2010.04.028] [PMID: 20417193]
[15]
Cummings DE, Naleid AM, Figlewicz Lattemann DP. Ghrelin: a link between energy homeostasis and drug abuse? Addict Biol 2007; 12(1): 1-5.
[http://dx.doi.org/10.1111/j.1369-1600.2007.00053.x] [PMID: 17407491]
[16]
Georgescu D, Zachariou V, Barrot M, et al. Involvement of the lateral hypothalamic peptide orexin in morphine dependence and withdrawal. J Neurosci 2003; 23(8): 3106-11.
[http://dx.doi.org/10.1523/JNEUROSCI.23-08-03106.2003] [PMID: 12716916]
[17]
Alvaro JD, Taylor JR, Duman RS. Molecular and behavioral interactions between central melanocortins and cocaine. J Pharmacol Exp Ther 2003; 304(1): 391-9.
[http://dx.doi.org/10.1124/jpet.102.040311] [PMID: 12490616]
[18]
Graham DL, Erreger K, Galli A, Stanwood GD. GLP-1 analog attenuates cocaine reward. Mol Psychiatry 2013; 18(9): 961-2.
[http://dx.doi.org/10.1038/mp.2012.141] [PMID: 23089631]
[19]
Krahn D, Kurth C, Demitrack M, Drewnowski A. The relationship of dieting severity and bulimic behaviors to alcohol and other drug use in young women. J Subst Abuse 1992; 4(4): 341-53.
[http://dx.doi.org/10.1016/0899-3289(92)90041-U] [PMID: 1294277]
[20]
Pisetsky EM, Chao YM, Dierker LC, May AM, Striegel-Moore RH. Disordered eating and substance use in high-school students: results from the Youth Risk Behavior Surveillance System. Int J Eat Disord 2008; 41(5): 464-70.
[http://dx.doi.org/10.1002/eat.20520] [PMID: 18348283]
[21]
Root TL, Pinheiro AP, Thornton L, et al. Substance use disorders in women with anorexia nervosa. Int J Eat Disord 2010; 43(1): 14-21.
[PMID: 19260043]
[22]
Wiederman MW, Pryor T. Substance use and impulsive behaviors among adolescents with eating disorders. Addict Behav 1996; 21(2): 269-72.
[http://dx.doi.org/10.1016/0306-4603(95)00062-3] [PMID: 8730530]
[23]
Cheskin LJ, Hess JM, Henningfield J, Gorelick DA. Calorie restriction increases cigarette use in adult smokers. Psychopharmacology (Berl) 2005; 179(2): 430-6.
[http://dx.doi.org/10.1007/s00213-004-2037-x] [PMID: 15565433]
[24]
French SA, Perry CL, Leon GR, Fulkerson JA. Weight concerns, dieting behavior, and smoking initiation among adolescents: a prospective study. Am J Public Health 1994; 84(11): 1818-20.
[http://dx.doi.org/10.2105/AJPH.84.11.1818] [PMID: 7977924]
[25]
Rosse R, Deutsch S, Chilton M. Cocaine addicts prone to cocaine-induced psychosis have lower body mass index than cocaine addicts resistant to cocaine-induced psychosis--Implications for the cocaine model of psychosis proneness. Isr J Psychiatry Relat Sci 2005; 42(1): 45-50.
[PMID: 16134406]
[26]
Coons EE, Cruce JA. Lateral hypothalamus: food current intensity in maintaining self-stimulation of hunger. Science 1968; 159(3819): 1117-9.
[http://dx.doi.org/10.1126/science.159.3819.1117] [PMID: 5636349]
[27]
Coons EE, White HA. Tonic properties of orosensation and the modulation of intracranial self-stimulation: the CNS weighting of external and internal factors governing reward. Ann N Y Acad Sci 1977; 290: 158-79.
[http://dx.doi.org/10.1111/j.1749-6632.1977.tb39725.x] [PMID: 276290]
[28]
Kornetsky C, Esposito RU. Euphorigenic drugs: effects on the reward pathways of the brain. Fed Proc 1979; 38(11): 2473-6.
[PMID: 488370]
[29]
Wise RA. Common neural basis for brain stimulation reward, drug reward, and food reward. In: Hoebel BG, Novin D, Eds. . The neural basis of feeding and reward. Brunswick, ME: Haer Institute 1982; pp. 445-54.
[30]
Wise RA, Hoffman DC. Localization of drug reward mechanisms by intracranial injections. Synapse 1992; 10(3): 247-63.
[http://dx.doi.org/10.1002/syn.890100307] [PMID: 1557697]
[31]
Hajnal A, Norgren R. Accumbens dopamine mechanisms in sucrose intake. Brain Res 2001; 904(1): 76-84.
[http://dx.doi.org/10.1016/S0006-8993(01)02451-9] [PMID: 11516413]
[32]
Ren X, Ferreira JG, Zhou L, Shammah-Lagnado SJ, Yeckel CW, de Araujo IE. Nutrient selection in the absence of taste receptor signaling. J Neurosci 2010; 30(23): 8012-23.
[http://dx.doi.org/10.1523/JNEUROSCI.5749-09.2010] [PMID: 20534849]
[33]
You ZB, Chen YQ, Wise RA. Dopamine and glutamate release in the nucleus accumbens and ventral tegmental area of rat following lateral hypothalamic self-stimulation. Neuroscience 2001; 107(4): 629-39.
[http://dx.doi.org/10.1016/S0306-4522(01)00379-7] [PMID: 11720786]
[34]
Pontieri FE, Tanda G, Di Chiara G. Intravenous cocaine, morphine, and amphetamine preferentially increase extracellular dopamine in the “shell” as compared with the “core” of the rat nucleus accumbens. Proc Natl Acad Sci USA 1995; 92(26): 12304-8.
[http://dx.doi.org/10.1073/pnas.92.26.12304] [PMID: 8618890]
[35]
Stellar JR, Corbett D. Regional neuroleptic microinjections indicate a role for nucleus accumbens in lateral hypothalamic self-stimulation reward. Brain Res 1989; 477(1-2): 126-43.
[http://dx.doi.org/10.1016/0006-8993(89)91400-5] [PMID: 2495150]
[36]
Salamone JD, Cousins MS, McCullough LD, Carriero DL, Berkowitz RJ. Nucleus accumbens dopamine release increases during instrumental lever pressing for food but not free food consumption. Pharmacol Biochem Behav 1994; 49(1): 25-31.
[http://dx.doi.org/10.1016/0091-3057(94)90452-9] [PMID: 7816884]
[37]
Lyness WH, Friedle NM, Moore KE. Destruction of dopaminergic nerve terminals in nucleus accumbens: effect on d-amphetamine self-administration. Pharmacol Biochem Behav 1979; 11(5): 553-6.
[http://dx.doi.org/10.1016/0091-3057(79)90040-6] [PMID: 531077]
[38]
Roberts DC, Koob GF, Klonoff P, Fibiger HC. Extinction and recovery of cocaine self-administration following 6-hydroxydopamine lesions of the nucleus accumbens. Pharmacol Biochem Behav 1980; 12(5): 781-7.
[http://dx.doi.org/10.1016/0091-3057(80)90166-5] [PMID: 7393973]
[39]
Carroll ME, Meisch RA. The effects of feeding conditions on drug-reinforced behavior: maintenance at reduced body weight versus availability of food. Psychopharmacology (Berl) 1980; 68(2): 121-4.
[http://dx.doi.org/10.1007/BF00432128] [PMID: 6107944]
[40]
Carroll ME, Meisch RA. Determinants of increased drug self-administration due to food deprivation. Psychopharmacology (Berl) 1981; 74(3): 197-200.
[http://dx.doi.org/10.1007/BF00427092] [PMID: 6115446]
[41]
DiLeone RJ, Georgescu D, Nestler EJ. Lateral hypothalamic neuropeptides in reward and drug addiction. Life Sci 2003; 73(6): 759-68.
[http://dx.doi.org/10.1016/S0024-3205(03)00408-9] [PMID: 12801597]
[42]
Liu S, Borgland SL. Regulation of the mesolimbic dopamine circuit by feeding peptides. Neuroscience 2015; 289: 19-42.
[http://dx.doi.org/10.1016/j.neuroscience.2014.12.046] [PMID: 25583635]
[43]
Cabanac M. Physiological role of pleasure. Science 1971; 173(4002): 1103-7.
[http://dx.doi.org/10.1126/science.173.4002.1103] [PMID: 5098954]
[44]
Zallar LJ, Farokhnia M, Tunstall BJ, Vendruscolo LF, Leggio L. The role of the ghrelin system in drug addiction. Int Rev Neurobiol 2017; 136: 89-119.
[http://dx.doi.org/10.1016/bs.irn.2017.08.002] [PMID: 29056157]
[45]
Khanh DV, Choi YH, Moh SH, Kinyua AW, Kim KW. Leptin and insulin signaling in dopaminergic neurons: relationship between energy balance and reward system. Front Psychol 2014; 5: 846.
[http://dx.doi.org/10.3389/fpsyg.2014.00846] [PMID: 25147530]
[46]
Navarro M. The role of the melanocortin system in drug and alcohol abuse. Int Rev Neurobiol 2017; 136: 121-50.
[http://dx.doi.org/10.1016/bs.irn.2017.06.009] [PMID: 29056149]
[47]
Quarta D, Smolders I. Rewarding, reinforcing and incentive salient events involve orexigenic hypothalamic neuropeptides regulating mesolimbic dopaminergic neurotransmission. Eur J Pharm Sci 2014; 57: 2-10.
[http://dx.doi.org/10.1016/j.ejps.2014.01.008] [PMID: 24472703]
[48]
Barson JR, Leibowitz SF. Orexin/hypocretin system: Role in food and drug overconsumption. Int Rev Neurobiol 2017; 136: 199-237.
[http://dx.doi.org/10.1016/bs.irn.2017.06.006] [PMID: 29056152]
[49]
Hao J, Cabeza de Vaca S, Carr KD. Effects of chronic ICV leptin infusion on motor-activating effects of D-amphetamine in food-restricted and ad libitum fed rats. Physiol Behav 2004; 83(3): 377-81.
[http://dx.doi.org/10.1016/j.physbeh.2004.08.007] [PMID: 15581659]
[50]
Hao J, Cabeza de Vaca S, Pan Y, Carr KD. Effects of central leptin infusion on the reward-potentiating effect of D-amphetamine. Brain Res 2006; 1087(1): 123-33.
[http://dx.doi.org/10.1016/j.brainres.2006.03.002] [PMID: 16600190]
[51]
Carr KD. Feeding, drug abuse, and the sensitization of reward by metabolic need. Neurochem Res 1996; 21(11): 1455-67.
[http://dx.doi.org/10.1007/BF02532386] [PMID: 8947935]
[52]
Levay EA, Tammer AH, Penman J, Kent S, Paolini AG. Calorie restriction at increasing levels leads to augmented concentrations of corticosterone and decreasing concentrations of testosterone in rats. Nutr Res 2010; 30(5): 366-73.
[http://dx.doi.org/10.1016/j.nutres.2010.05.001] [PMID: 20579529]
[53]
Mattson MP. Dietary factors, hormesis and health. Ageing Res Rev 2008; 7(1): 43-8.
[http://dx.doi.org/10.1016/j.arr.2007.08.004] [PMID: 17913594]
[54]
165. Lutter M, Krishnan V, Russo SJ, Jung S, McClung CA, Nestler EJ. Orexin signaling mediates the antidepressant-like effect of calorie restriction. J Neurosci 2008; 28: 3071-5.
[http://dx.doi.org/10.1523/JNEUROSCI.5584-07.2008]
[55]
Willette AA, Coe CL, Colman RJ, et al. Calorie restriction reduces psychological stress reactivity and its association with brain volume and microstructure in aged rhesus monkeys. Psychoneuroendocrinology 2012; 37: 903-16.
[http://dx.doi.org/10.1016/j.psyneuen.2011.10.006]
[56]
Deroche V, Marinelli M, Maccari S, Le Moal M, Simon H, Piazza PV. Stress-induced sensitization and glucocorticoids. I. Sensitization of dopamine-dependent locomotor effects of amphetamine and morphine depends on stress-induced corticosterone secretion. J Neurosci 1995; 15(11): 7181-8.
[http://dx.doi.org/10.1523/JNEUROSCI.15-11-07181.1995] [PMID: 7472472]
[57]
Marinković P, Pesić V, Loncarević N, Smiljanić K, Kanazir S, Ruzdijić S. Behavioral and biochemical effects of various food-restriction regimens in the rats. Physiol Behav 2007; 92(3): 492-9.
[http://dx.doi.org/10.1016/j.physbeh.2007.04.023] [PMID: 17524433]
[58]
Sharpe AL, Klaus JD, Beckstead MJ. Meal schedule influences food restriction-induced locomotor sensitization to methamphetamine. Psychopharmacology (Berl) 2012; 219(3): 795-803.
[http://dx.doi.org/10.1007/s00213-011-2401-6] [PMID: 21750897]
[59]
Ambroggi F, Turiault M, Milet A, et al. Stress and addiction: glucocorticoid receptor in dopaminoceptive neurons facilitates cocaine seeking. Nat Neurosci 2009; 12(3): 247-9.
[http://dx.doi.org/10.1038/nn.2282] [PMID: 19234455]
[60]
Zheng D, Liu S, Cabeza de Vaca S, Carr KD. Effects of time of feeding on psychostimulant reward, conditioned place preference, metabolic hormone levels, and nucleus accumbens biochemical measures in food-restricted rats. Psychopharmacology (Berl) 2013; 227(2): 307-20.
[http://dx.doi.org/10.1007/s00213-013-2981-4] [PMID: 23354537]
[61]
Sedki F, Abbas Z, Angelis S, Martin J, D’Cunha T, Shalev U. Is it stress? The role of stress related systems in chronic food restriction-induced augmentation of heroin seeking in the rat. Front Neurosci 2013; 7: 98.
[http://dx.doi.org/10.3389/fnins.2013.00098] [PMID: 23761730]
[62]
Carroll ME, Campbell UC, Heideman P. Ketoconazole suppresses food restriction-induced increases in heroin self-administration in rats: sex differences. Exp Clin Psychopharmacol 2001; 9(3): 307-16.
[http://dx.doi.org/10.1037/1064-1297.9.3.307] [PMID: 11534541]
[63]
Carr KD. Nucleus accumbens AMPA receptor trafficking upregulated by food restriction: An unintended target for drugs of abuse and forbidden foods. Curr Opin Behav Sci 2016; 9: 32-9.
[http://dx.doi.org/10.1016/j.cobeha.2015.11.019] [PMID: 26744733]
[64]
Pan Y, Chau L, Liu S, Avshalumov MV, Rice ME, Carr KD. A food restriction protocol that increases drug reward decreases tropomyosin receptor kinase B in the ventral tegmental area, with no effect on brain-derived neurotrophic factor or tropomyosin receptor kinase B protein levels in dopaminergic forebrain regions. Neuroscience 2011; 197: 330-8.
[http://dx.doi.org/10.1016/j.neuroscience.2011.08.065] [PMID: 21945647]
[65]
Stouffer MA, Woods CA, Patel JC, et al. Insulin enhances striatal dopamine release by activating cholinergic interneurons and thereby signals reward. Nat Commun 2015; 6: 8543.
[http://dx.doi.org/10.1038/ncomms9543] [PMID: 26503322]
[66]
Pothos EN, Hernandez L, Hoebel BG. Chronic food deprivation decreases extracellular dopamine in the nucleus accumbens: implications for a possible neurochemical link between weight loss and drug abuse. Obes Res 1995; 3(Suppl. 4): 525S-9S.
[http://dx.doi.org/10.1002/j.1550-8528.1995.tb00222.x] [PMID: 8697053]
[67]
Pothos EN, Creese I, Hoebel BG. Restricted eating with weight loss selectively decreases extracellular dopamine in the nucleus accumbens and alters dopamine response to amphetamine, morphine, and food intake. J Neurosci 1995; 15(10): 6640-50.
[http://dx.doi.org/10.1523/JNEUROSCI.15-10-06640.1995] [PMID: 7472425]
[68]
Almundarij TI, Gavini CK, Novak CM. Suppressed sympathetic outflow to skeletal muscle, muscle thermogenesis, and activity energy expenditure with calorie restriction. Physiol Rep 2017; 5(4)e13171
[http://dx.doi.org/10.14814/phy2.13171] [PMID: 28242830]
[69]
Pan Y, Berman Y, Haberny S, Meller E, Carr KD. Synthesis, protein levels, activity, and phosphorylation state of tyrosine hydroxylase in mesoaccumbens and nigrostriatal dopamine pathways of chronically food-restricted rats. Brain Res 2006; 1122(1): 135-42.
[http://dx.doi.org/10.1016/j.brainres.2006.09.001] [PMID: 17010321]
[70]
Jones KT, Woods C, Zhen J, Antonio T, Carr KD, Reith ME. Effects of diet and insulin on dopamine transporter activity and expression in rat caudate-putamen, nucleus accumbens, and midbrain. J Neurochem 2017; 140(5): 728-40.
[http://dx.doi.org/10.1111/jnc.13930] [PMID: 27973691]
[71]
Bassareo V, Di Chiara G. Differential responsiveness of dopamine transmission to food-stimuli in nucleus accumbens shell/core compartments. Neuroscience 1999; 89(3): 637-41.
[http://dx.doi.org/10.1016/S0306-4522(98)00583-1] [PMID: 10199600]
[72]
Rougé-Pont F, Marinelli M, Le Moal M, Simon H, Piazza PV. Stress-induced sensitization and glucocorticoids. II. Sensitization of the increase in extracellular dopamine induced by cocaine depends on stress-induced corticosterone secretion. J Neurosci 1995; 15(11): 7189-95.
[http://dx.doi.org/10.1523/JNEUROSCI.15-11-07189.1995] [PMID: 7472473]
[73]
Cadoni C, Solinas M, Valentini V, Di Chiara G. Selective psychostimulant sensitization by food restriction: differential changes in accumbens shell and core dopamine. Eur J Neurosci 2003; 18(8): 2326-34.
[http://dx.doi.org/10.1046/j.1460-9568.2003.02941.x] [PMID: 14622194]
[74]
Haberny SL, Carr KD. Comparison of basal and D-1 dopamine receptor agonist-stimulated neuropeptide gene expression in caudate-putamen and nucleus accumbens of ad libitum fed and food-restricted rats. Brain Res Mol Brain Res 2005; 141(2): 121-7.
[http://dx.doi.org/10.1016/j.molbrainres.2005.08.001] [PMID: 16257473]
[75]
Gerfen CR, Engber TM, Mahan LC, et al. D1 and D2 dopamine receptor-regulated gene expression of striatonigral and striatopallidal neurons. Science 1990; 250(4986): 1429-32.
[http://dx.doi.org/10.1126/science.2147780] [PMID: 2147780]
[76]
Le Moine C, Bloch B. D1 and D2 dopamine receptor gene expression in the rat striatum: sensitive cRNA probes demonstrate prominent segregation of D1 and D2 mRNAs in distinct neuronal populations of the dorsal and ventral striatum. J Comp Neurol 1995; 355(3): 418-26.
[http://dx.doi.org/10.1002/cne.903550308] [PMID: 7636023]
[77]
Carr KD, Kutchukhidze N. Chronic food restriction increases fos-like immunoreactivity (FLI) induced in rat forebrain by intraventricular amphetamine. Brain Res 2000; 861(1): 88-96.
[http://dx.doi.org/10.1016/S0006-8993(00)02018-7] [PMID: 10751568]
[78]
Carr KD, Tsimberg Y, Berman Y, Yamamoto N. Evidence of increased dopamine receptor signaling in food-restricted rats. Neuroscience 2003; 119(4): 1157-67.
[http://dx.doi.org/10.1016/S0306-4522(03)00227-6] [PMID: 12831870]
[79]
Carr KD, Kim GY, Cabeza de Vaca S. Rewarding and locomotor-activating effects of direct dopamine receptor agonists are augmented by chronic food restriction in rats. Psychopharmacology (Berl) 2001; 154(4): 420-8.
[http://dx.doi.org/10.1007/s002130000674] [PMID: 11349397]
[80]
Carr KD, Cabeza de Vaca S, Sun Y, Chau LS. Reward-potentiating effects of D-1 dopamine receptor agonist and AMPAR GluR1 antagonist in nucleus accumbens shell and their modulation by food restriction. Psychopharmacology (Berl) 2009; 202(4): 731-43.
[http://dx.doi.org/10.1007/s00213-008-1355-9] [PMID: 18841347]
[81]
Haberny SL, Carr KD. Food restriction increases NMDA receptor-mediated calcium-calmodulin kinase II and NMDA receptor/extracellular signal-regulated kinase 1/2-mediated cyclic amp response element-binding protein phosphorylation in nucleus accumbens upon D-1 dopamine receptor stimulation in rats. Neuroscience 2005; 132(4): 1035-43.
[http://dx.doi.org/10.1016/j.neuroscience.2005.02.006] [PMID: 15857708]
[82]
Haberny SL, Berman Y, Meller E, Carr KD. Chronic food restriction increases D-1 dopamine receptor agonist-induced phosphorylation of extracellular signal-regulated kinase 1/2 and cyclic AMP response element-binding protein in caudate-putamen and nucleus accumbens. Neuroscience 2004; 125(1): 289-98.
[http://dx.doi.org/10.1016/j.neuroscience.2004.01.037] [PMID: 15051167]
[83]
Carr KD, de Vaca SC, Sun Y, Chau LS, Pan Y, Dela Cruz J. Effects of the MEK inhibitor, SL-327, on rewarding, motor- and cellular-activating effects of D-amphetamine and SKF-82958, and their augmentation by food restriction in rat. Psychopharmacology (Berl) 2009; 201(4): 495-506.
[http://dx.doi.org/10.1007/s00213-008-1313-6] [PMID: 18766328]
[84]
Serulle Y, Zhang S, Ninan I, et al. A GluR1-cGKII interaction regulates AMPA receptor trafficking. Neuron 2007; 56(4): 670-88.
[http://dx.doi.org/10.1016/j.neuron.2007.09.016] [PMID: 18031684]
[85]
Boehm J, Kang M-G, Johnson R-C, Esteban J, Huganir RL, Malinow R. Synaptic incorporation of AMPA receptors during LTP is controlled by a PKC phosphorylation site on GluR1. Neuron 2006; 51(2): 213-25.
[http://dx.doi.org/10.1016/j.neuron.2006.06.013] [PMID: 16846856]
[86]
Esteban JA, Shi SH, Wilson C, Nuriya M, Huganir RL, Malinow R. PKA phosphorylation of AMPA receptor subunits controls synaptic trafficking underlying plasticity. Nat Neurosci 2003; 6(2): 136-43.
[http://dx.doi.org/10.1038/nn997] [PMID: 12536214]
[87]
Mangiavacchi S, Wolf ME. D1 dopamine receptor stimulation increases the rate of AMPA receptor insertion onto the surface of cultured nucleus accumbens neurons through a pathway dependent on protein kinase A. J Neurochem 2004; 88(5): 1261-71.
[http://dx.doi.org/10.1046/j.1471-4159.2003.02248.x] [PMID: 15009682]
[88]
Peng XX, Cabeza de Vaca S, Ziff EB, Carr KD. GluA1-containing AMPA receptors are trafficked to the nucleus accumbens postsynaptic density in response to food restriction and d-amphetamine and potentiate reward. Psychopharmacol 2014; 231: 3055-63.
[http://dx.doi.org/10.1007/s00213-014-3476-7]
[89]
Carr KD, Chau LS, Cabeza de Vaca S, et al. AMPA receptor subunit GluR1 downstream of D-1 dopamine receptor stimulation in nucleus accumbens shell mediates increased drug reward magnitude in food-restricted rats. Neuroscience 2010; 165(4): 1074-86.
[http://dx.doi.org/10.1016/j.neuroscience.2009.11.015] [PMID: 19931598]
[90]
Peng XX, Ziff EB, Carr KD. Effects of food restriction and sucrose intake on synaptic delivery of AMPA receptors in nucleus accumbens. Synapse 2011; 65(10): 1024-31.
[http://dx.doi.org/10.1002/syn.20931] [PMID: 21425350]
[91]
Reimers JM, Milovanovic M, Wolf ME. Quantitative analysis of AMPA receptor subunit composition in addiction-related brain regions. Brain Res 2011; 1367: 223-33.
[http://dx.doi.org/10.1016/j.brainres.2010.10.016] [PMID: 20946890]
[92]
Boudreau AC, Wolf ME. Behavioral sensitization to cocaine is associated with increased AMPA receptor surface expression in the nucleus accumbens. J Neurosci 2005; 25(40): 9144-51.
[http://dx.doi.org/10.1523/JNEUROSCI.2252-05.2005] [PMID: 16207873]
[93]
Ouyang J, Carcea I, Schiavo JK, et al. Food restriction induces synaptic incorporation of calcium-permeable AMPA receptors in nucleus accumbens. Eur J Neurosci 2017; 45(6): 826-36.
[http://dx.doi.org/10.1111/ejn.13528] [PMID: 28112453]
[94]
Lee HK. Ca-permeable AMPA receptors in homeostatic synaptic plasticity. Front Mol Neurosci 2012; 5: 17.
[http://dx.doi.org/10.3389/fnmol.2012.00017] [PMID: 22347846]
[95]
Thiagarajan TC, Lindskog M, Tsien RW. Adaptation to synaptic inactivity in hippocampal neurons. Neuron 2005; 47(5): 725-37.
[http://dx.doi.org/10.1016/j.neuron.2005.06.037] [PMID: 16129401]
[96]
Kim S, Ziff EB. Calcineurin mediates synaptic scaling via synaptic trafficking of Ca2+-permeable AMPA receptors. PLoS Biol 2014; 12(7)e1001900
[http://dx.doi.org/10.1371/journal.pbio.1001900] [PMID: 24983627]
[97]
Tukey DS, Ziff EB. Ca2+-permeable AMPA receptors and dopamine D1 receptors regulate GluA1 trafficking in striatal neurons. J Biol Chem 2013; 288: 35297-306.
[http://dx.doi.org/10.1074/jbc.M113.516690] [PMID: 24133208]
[98]
Carter AG, Sabatini BL. State-dependent calcium signaling in dendritic spines of striatal medium spiny neurons. Neuron 2004; 44(3): 483-93.
[http://dx.doi.org/10.1016/j.neuron.2004.10.013] [PMID: 15504328]
[99]
Conrad KL, Tseng KY, Uejima JL, et al. Formation of accumbens GluR2-lacking AMPA receptors mediates incubation of cocaine craving. Nature 2008; 454(7200): 118-21.
[http://dx.doi.org/10.1038/nature06995] [PMID: 18500330]
[100]
Jedynak J, Hearing M, Ingebretson A, et al. Cocaine and amphetamine induce overlapping but distinct patterns of AMPAR plasticity in nucleus accumbens medium spiny neurons. Neuropsychopharmacology 2016; 41(2): 464-76.
[http://dx.doi.org/10.1038/npp.2015.168] [PMID: 26068728]
[101]
Oginsky MF, Goforth PB, Nobile CW, Lopez-Santiago LF, Ferrario CR. Eating ‘junk food’ produces rapid and long-lasting increases in NAc CP-AMPA receptors: implications for enhanced cue-induced motivation and food addiction. Neuropsychopharmacology 2016; 41(13): 2977-86.
[102]
Koutsokera M, Kafkalias P, Giompres P, Kouvelas ED, Mitsacos A. Expression and phosphorylation of glutamate receptor subunits and CaMKII in a mouse model of Parkinsonism. Brain Res 2014; 1549: 22-31.
[http://dx.doi.org/10.1016/j.brainres.2013.12.023] [PMID: 24418465]
[103]
Bagetta V, Sgobio C, Pendolino V, et al. Rebalance of striatal NMDA/AMPA receptor ratio underlies the reduced emergence of dyskinesia during D2-like dopamine agonist treatment in experimental Parkinson’s disease. J Neurosci 2012; 32(49): 17921-31.
[http://dx.doi.org/10.1523/JNEUROSCI.2664-12.2012] [PMID: 23223310]
[104]
Groc L, Choquet D, Chaouloff F. The stress hormone corticosterone conditions AMPAR surface trafficking and synaptic potentiation. Nat Neurosci 2008; 11(8): 868-70.
[http://dx.doi.org/10.1038/nn.2150] [PMID: 18622402]
[105]
Krugers HJ, Hoogenraad CC, Groc L. Stress hormones and AMPA receptor trafficking in synaptic plasticity and memory. Nat Rev Neurosci 2010; 11:675-681. Nat Rev Neurosci 2011; 11: 675-81.
[106]
Yuen EY, Liu W, Karatsoreos IN, et al. Mechanisms for acute stress-induced enhancement of glutamatergic transmission and working memory. Mol Psychiatry 2011; 16: 156-70.
[107]
Ribeiro LF, Catarino T, Santos SD, et al. Ghrelin triggers the synaptic incorporation of AMPA receptors in the hippocampus. Proc Natl Acad Sci USA 2014; 111(1): E149-58.
[http://dx.doi.org/10.1073/pnas.1313798111] [PMID: 24367106]
[108]
Zigman JM, Jones JE, Lee CE, Saper CB, Elmquist JK. Expression of ghrelin receptor mRNA in the rat and the mouse brain. J Comp Neurol 2006; 494(3): 528-48.
[http://dx.doi.org/10.1002/cne.20823] [PMID: 16320257]
[109]
Moult PR, Cross A, Santos SD, et al. Leptin regulates AMPA receptor trafficking via PTEN inhibition. J Neurosci 2010; 30(11): 4088-101.
[http://dx.doi.org/10.1523/JNEUROSCI.3614-09.2010] [PMID: 20237279]
[110]
Lee JW, Kim WY, Kim JH. Leptin in the nucleus accumbens blocks the increase of GluA1 phosphorylation induced by acute cocaine administration. Neuroreport 2018; 29(6): 483-7.
[http://dx.doi.org/10.1097/WNR.0000000000001001] [PMID: 29521680]
[111]
Lobo MK, Covington HE III, Chaudhury D, et al. Cell type-specific loss of BDNF signaling mimics optogenetic control of cocaine reward. Science 2010; 330(6002): 385-90.
[http://dx.doi.org/10.1126/science.1188472] [PMID: 20947769]
[112]
Kravitz AV, Tye LD, Kreitzer AC. Distinct roles for direct and indirect pathway striatal neurons in reinforcement. Nat Neurosci 2012; 15(6): 816-8.
[http://dx.doi.org/10.1038/nn.3100] [PMID: 22544310]
[113]
Cole SL, Robinson MJF, Berridge KC. Optogenetic self-stimulation in the nucleus accumbens: D1 reward versus D2 ambivalence. PLoS One 2018; 13(11): e0207694
[http://dx.doi.org/10.1371/journal.pone.0207694] [PMID: 30496206]
[114]
Soares-Cunha C, Coimbra B, David-Pereira A, et al. Activation of D2 dopamine receptor-expressing neurons in the nucleus accumbens increases motivation. Nat Commun 2016; 7: 11829.
[http://dx.doi.org/10.1038/ncomms11829]
[115]
Dalley JW, Lääne K, Theobald DEH, et al. Time-limited modulation of appetitive Pavlovian memory by D1 and NMDA receptors in the nucleus accumbens. Proc Natl Acad Sci USA 2005; 102(17): 6189-94.
[http://dx.doi.org/10.1073/pnas.0502080102] [PMID: 15833811]
[116]
Hyman SE, Malenka RC, Nestler EJ. Neural mechanisms of addiction: the role of reward-related learning and memory. Annu Rev Neurosci 2006; 29: 565-98.
[http://dx.doi.org/10.1146/annurev.neuro.29.051605.113009] [PMID: 16776597]
[117]
Kelley AE. Ventral striatal control of appetitive motivation: role in ingestive behavior and reward-related learning. Neurosci Biobehav Rev 2004; 27(8): 765-76.
[http://dx.doi.org/10.1016/j.neubiorev.2003.11.015] [PMID: 15019426]
[118]
Sesack SR, Grace AA. Cortico-Basal Ganglia reward network: microcircuitry. Neuropsychopharmacology 2010; 35(1): 27-47.
[http://dx.doi.org/10.1038/npp.2009.93] [PMID: 19675534]
[119]
French SJ, Totterdell S. Hippocampal and prefrontal cortical inputs monosynaptically converge with individual projection neurons of the nucleus accumbens. J Comp Neurol 2002; 446(2): 151-65.
[http://dx.doi.org/10.1002/cne.10191] [PMID: 11932933]
[120]
French SJ, Totterdell S. Individual nucleus accumbens-projection neurons receive both basolateral amygdala and ventral subicular afferents in rats. Neuroscience 2003; 119(1): 19-31.
[http://dx.doi.org/10.1016/S0306-4522(03)00150-7] [PMID: 12763065]
[121]
Berendse HW, Groenewegen HJ. Organization of the thalamostriatal projections in the rat, with special emphasis on the ventral striatum. J Comp Neurol 1990; 299(2): 187-228.
[http://dx.doi.org/10.1002/cne.902990206] [PMID: 2172326]
[122]
Brog JS, Salyapongse A, Deutch AY, Zahm DS. The patterns of afferent innervation of the core and shell in the “accumbens” part of the rat ventral striatum: immunohistochemical detection of retrogradely transported fluoro-gold. J Comp Neurol 1993; 338(2): 255-78.
[http://dx.doi.org/10.1002/cne.903380209] [PMID: 8308171]
[123]
Li S, Kirouac GJ. Projections from the paraventricular nucleus of the thalamus to the forebrain, with special emphasis on the extended amygdala. J Comp Neurol 2008; 506(2): 263-87.
[http://dx.doi.org/10.1002/cne.21502] [PMID: 18022956]
[124]
Britt JP, Benaliouad F, McDevitt RA, Stuber GD, Wise RA, Bonci A. Synaptic and behavioral profile of multiple glutamatergic inputs to the nucleus accumbens. Neuron 2012; 76(4): 790-803.
[http://dx.doi.org/10.1016/j.neuron.2012.09.040] [PMID: 23177963]
[125]
Stuber GD, Sparta DR, Stamatakis AM, et al. Amygdala to nucleus accumbens excitatory transmission facilitates reward seeking. Nature 2011; 475: 377-80.
[http://dx.doi.org/10.1038/nature10194] [PMID: 21716290]
[126]
Stuber GD, Britt JP, Bonci A. Optogenetic modulation of neural circuits that underlie reward seeking. Biol Psychiatry 2012; 71(12): 1061-7.
[http://dx.doi.org/10.1016/j.biopsych.2011.11.010] [PMID: 22196983]
[127]
Zhang S, Qi J, Li X, et al. Dopaminergic and glutamatergic microdomains in a subset of rodent mesoaccumbens axons. Nat Neurosci 2015; 18(3): 386-92.
[http://dx.doi.org/10.1038/nn.3945] [PMID: 25664911]
[128]
Stuber GD, Hnasko TS, Britt JP, Edwards RH, Bonci A. Dopaminergic terminals in the nucleus accumbens but not the dorsal striatum corelease glutamate. J Neurosci 2010; 30(24): 8229-33.
[http://dx.doi.org/10.1523/JNEUROSCI.1754-10.2010] [PMID: 20554874]
[129]
Tecuapetla F, Patel JC, Xenias H, et al. Glutamatergic signaling by mesolimbic dopamine neurons in the nucleus accumbens. J Neurosci 2010; 30(20): 7105-10.
[http://dx.doi.org/10.1523/JNEUROSCI.0265-10.2010] [PMID: 20484653]
[130]
Root DH, Estrin DJ, Morales M. Aversion or salience signaling by ventral tegmental area glutamate neurons. iScience 2018; 2: 51-62.
[131]
Choquet D. Fast AMPAR trafficking for a high-frequency synaptic transmission. Eur J Neurosci 2010; 32(2): 250-60.
[http://dx.doi.org/10.1111/j.1460-9568.2010.07350.x] [PMID: 20646044]
[132]
Kauer JA, Malenka RC. Synaptic plasticity and addiction. Nat Rev Neurosci 2007; 8(11): 844-58.
[http://dx.doi.org/10.1038/nrn2234] [PMID: 17948030]
[133]
Lüscher C, Malenka RC. Drug-evoked synaptic plasticity in addiction: from molecular changes to circuit remodeling. Neuron 2011; 69(4): 650-63.
[http://dx.doi.org/10.1016/j.neuron.2011.01.017] [PMID: 21338877]
[134]
Stice E, Davis K, Miller NP, Marti CN. Fasting increases risk for onset of binge eating and bulimic pathology: a 5-year prospective study. J Abnorm Psychol 2008; 117(4): 941-6.
[http://dx.doi.org/10.1037/a0013644] [PMID: 19025239]
[135]
Wardle J, Steptoe A, Oliver G, Lipsey Z. Stress, dietary restraint and food intake. J Psychosom Res 2000; 48(2): 195-202.
[http://dx.doi.org/10.1016/S0022-3999(00)00076-3] [PMID: 10719137]

Rights & Permissions Print Cite
Article Metrics
12
3
© 2024 Bentham Science Publishers | Privacy Policy