Recent Developments in Tritium Incorporation for Radiotracer Studies

Manouchehr      Saljoughian; Philip   G.   Williams

doi:10.2174/1381612003399969

Abstract

The essential nature of rapid radiotracer synthesis very early in drug discovery programs has driven the need for better and more varied tritium incorporation methods. This review presents a summary of recent advances for tritium introduction via tritiated water, tritium gas, complex tritides, and a range of recently improved tritiation reagents. Access to a wider range of tritiated reagents (for tritioacetylation, tritioformylation, methylation, etc.) and commercial manifolds for the transfer and use of tritium gas is also discussed.

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Current Pharmaceutical Design

Title: Recent Developments in Tritium Incorporation for Radiotracer Studies

Volume: 6 Issue: 10

Author(s): Manouchehr Saljoughian and Philip G. Williams

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Abstract: The essential nature of rapid radiotracer synthesis very early in drug discovery programs has driven the need for better and more varied tritium incorporation methods. This review presents a summary of recent advances for tritium introduction via tritiated water, tritium gas, complex tritides, and a range of recently improved tritiation reagents. Access to a wider range of tritiated reagents (for tritioacetylation, tritioformylation, methylation, etc.) and commercial manifolds for the transfer and use of tritium gas is also discussed.

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Saljoughian Manouchehr and Williams G. Philip, Recent Developments in Tritium Incorporation for Radiotracer Studies, Current Pharmaceutical Design 2000; 6 (10) . https://dx.doi.org/10.2174/1381612003399969