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Review Article

天然产物对多形性胶质母细胞瘤的保护作用:对一氧化氮途径的关注

卷 28, 期 2, 2021

发表于: 30 January, 2020

页: [377 - 400] 页: 24

弟呕挨: 10.2174/0929867327666200130104757

价格: $65

摘要

尽管有手术切除、化疗和放疗等治疗方法，但多形性胶质母细胞瘤仍然是一种无法治愈的致命疾病。这就需要进一步的治疗选择来提高现有治疗方法的疗效。一氧化氮(NO)是一种短寿小分子，在GBM的病理生理中起着重要作用。多项研究表明NO参与细胞凋亡、转移、细胞增殖、血管生成、侵袭等许多与GBM病理生物学相关的过程。在此，我们详细阐述了NO作为GBM治疗靶点的作用，并讨论了一些影响NO信号通路的天然产物。

关键词: 多形性胶质母细胞瘤，一氧化氮，凋亡，转移，血管生成，天然产物。

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