Abstract
Migraine is a common neurologic condition marked by recurrent episodes of headache. Its pathophysiology is highly complex involving neuronal, inflammatory and vascular mechanisms. The Renin-Angiotensin System (RAS) can modulate all these mechanism, being a potential pharmacological target for migraine treatment. We carried out a systematic review of the studies evaluating the involvement of RAS in patients with migraine. There is evidence from genetic studies exploring the relation between migraine and RAS-related genes and from clinical trials evaluating the efficacy of Angiotensin II Type 1 (AT1) receptor antagonists and angiotensin converting enzyme inhibitors in migraine prophylaxis. RAS seems to play a role in the pathophysiology of migraine, but more direct evidence is still missing.
Keywords: Renin, angiotensin, aldosterone, migraine, headache, genetics.
Graphical Abstract
[http://dx.doi.org/10.1056/NEJMcp1605502] [PMID: 28792865]
[http://dx.doi.org/10.1001/jama.296.10.1274] [PMID: 16968852]
[http://dx.doi.org/10.1056/NEJMra010917] [PMID: 11807151]
[http://dx.doi.org/10.1001/jama.301.24.2608] [PMID: 19549980]
[http://dx.doi.org/10.1007/s10194-012-0480-3] [PMID: 22940870]
[http://dx.doi.org/10.1056/NEJMe1712559] [PMID: 29171812]
[http://dx.doi.org/10.17712/nsj.2016.3.20150506] [PMID: 27356650]
[http://dx.doi.org/10.1111/head.13281] [PMID: 29527677]
[http://dx.doi.org/10.1046/j.1526-4610.1998.3804295.x] [PMID: 9595870]
[http://dx.doi.org/10.2147/PROM.S31392] [PMID: 24143125]
[http://dx.doi.org/10.5056/jnm.2013.19.4.516] [PMID: 24199013]
[http://dx.doi.org/10.1212/WNL.0000000000002789] [PMID: 27335112]
[http://dx.doi.org/10.1007/s11916-014-0453-0] [PMID: 25230799]
[http://dx.doi.org/10.1371/journal.pone.0149577] [PMID: 26901341]
[http://dx.doi.org/10.1007/s11916-010-0112-z] [PMID: 20425190]
[PMID: 19750119]
[http://dx.doi.org/10.2147/NDT.S3497] [PMID: 19337456]
[http://dx.doi.org/10.1177/0333102419869319]
[http://dx.doi.org/10.1016/S1474-4422(15)00184-2] [PMID: 26636144]
[http://dx.doi.org/10.3389/fncel.2018.00233] [PMID: 30127722]
[http://dx.doi.org/10.1016/S1474-4422(09)70358-8] [PMID: 20170844]
[http://dx.doi.org/10.1016/j.pain.2013.07.021]
[http://dx.doi.org/10.1111/j.1468-2982.2008.01578.x] [PMID: 18460007]
[http://dx.doi.org/10.1371/journal.pmed.1000097] [PMID: 19621072]
[PMID: 11300977]
[http://dx.doi.org/10.1136/bmj.322.7277.19] [PMID: 11141144]
[http://dx.doi.org/10.1001/jama.289.1.65] [PMID: 12503978]
[http://dx.doi.org/10.1111/j.1526-4610.2006.00382.x] [PMID: 16618270]
[http://dx.doi.org/10.1111/j.1468-2982.2008.01825.x] [PMID: 19250283]
[http://dx.doi.org/10.1002/pds.893] [PMID: 14971122]
[http://dx.doi.org/10.1007/s10072-017-2854-4] [PMID: 28224326]
[http://dx.doi.org/10.1111/j.1468-1331.2007.01764.x] [PMID: 17539955]
[http://dx.doi.org/10.1007/s10194-009-0182-7] [PMID: 20063032]
[http://dx.doi.org/10.1007/s10072-015-2217-y] [PMID: 25917398]
[http://dx.doi.org/10.1016/j.neulet.2004.10.041] [PMID: 15644278]
[http://dx.doi.org/10.1016/j.molbrainres.2005.01.006] [PMID: 15893594]
[PMID: 16252613]
[http://dx.doi.org/10.1111/j.1468-2982.2006.01269.x] [PMID: 17381556]
[http://dx.doi.org/10.1111/j.1526-4610.2008.01287.x] [PMID: 19178574]
[http://dx.doi.org/10.1111/j.1468-2982.2008.01824.x] [PMID: 19298544]
[PMID: 28360555]
[http://dx.doi.org/10.1111/head.12008] [PMID: 23278516]
[PMID: 28360555]
[http://dx.doi.org/10.4103/0972-2327.99993]
[http://dx.doi.org/10.1155/2015/629382]
[http://dx.doi.org/10.2174/0929867325666180226102358] [PMID: 29484978]
[http://dx.doi.org/10.3390/ijms19030876] [PMID: 29543776]
[http://dx.doi.org/10.1586/14737175.2016.1150179] [PMID: 26852820]
[http://dx.doi.org/10.1016/j.neuroscience.2008.11.044] [PMID: 19116162]
[http://dx.doi.org/10.1291/hypres.31.161] [PMID: 18360031]
[http://dx.doi.org/10.1038/jcbfm.2010.191] [PMID: 21045864]
[http://dx.doi.org/10.1046/j.1468-2982.2003.00627.x] [PMID: 14616932]
[http://dx.doi.org/10.1212/WNL.0b013e3181a71220] [PMID: 19470970]
[http://dx.doi.org/10.1136/bmjopen-2017-020498] [PMID: 29593023]
[http://dx.doi.org/10.1111/j.1467-789X.2010.00791.x] [PMID: 20673279]
[http://dx.doi.org/10.4103/jnrp.jnrp_146_18] [PMID: 30765967]