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Current Drug Discovery Technologies

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ISSN (Online): 1875-6220

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Review Article

Current Development on Chitosan-based Antimicrobial Drug Formulations for the Wound Healing

Author(s): Harekrishna Roy*, Shaik A. Rahaman, Theendra V. Kumar and Sisir Nandi*

Volume 17, Issue 4, 2020

Page: [534 - 541] Pages: 8

DOI: 10.2174/1570163817666200123122532

Price: $65

Abstract

Background: Derived from polyose, chitosan is an outstanding natural linear polysaccharide comprised of random arrangement of β-(1-4)-linked D-Glucosamine and N-acetyl-DGlucosamine units.

Objective: Researchers have been using chitosan as a network forming or gelling agent with economically available, present polyose, low immunogenicity, biocompatibility, non-toxicity, biodegradability, protects against secretion from irritation and don’t suffer the danger of transmission animal infective agent.

Methods: Furthermore, recent studies gear up the chitosan used in the development of various biopharmaceutical formulations, including nanoparticles, hydrogels, implants, films, fibers, etc.

Results: These formulations produce potential activities as antimicrobials, cancer treatment, medical aid, and wound healing, controlled unleash device or drug trigger retarding device and 3DBiomedical sponge, etc.

Conclusion: The present article discusses the development of various drug formulations utilizing chitosan as biopolymers for the repairing of broken tissues and healing in case of wound infection.

Keywords: Natural linear polysaccharide, chitosan, films, hydrogels, nanoparticles, fibers, implant coatings, wound care.

Graphical Abstract

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