摘要
心血管疾病(CVD)已成为男性和女性发病和死亡的主要原因之一。根据世界卫生组织(WHO)的说法,冠状动脉壁上的斑块导致冠状动脉狭窄,导致氧气和血液不能充分流向心脏,缺血性心脏病是主要问题,被称为“冠状动脉疾病”。与过去十年相比,2016年心血管疾病死亡率上升了15%(约1760万)。这一巨大的增长推动了一种适用于快速和早期诊断的生物标志物的发展。目前,C反应蛋白(CRP)在临床分析中被认为是一种具有快速和准确结果的杰出生物标志物。各种技术也被用于诊断CVD,包括表面等离子体共振(SPR),比色法,酶联免疫吸附测定(ELISA),荧光免疫测定,化学发光测定和电测量。这篇综述讨论了这种诊断策略以及当前的尖端技术如何使高性能检测方法得以发展。结论性评论涉及了纳米材料在医学诊断中的临床意义和纳米otheranostics的应用。
关键词: 心血管疾病,C反应蛋白,生物传感器,临床生物标志物,纳米材料,高性能检测
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