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Review Article

胆道癌临床和转化研究的挑战

卷 27, 期 29, 2020

页: [4756 - 4777] 页: 22

弟呕挨: 10.2174/0929867327666200123090153

价格: $65

摘要

背景：胆道癌（BTC）是罕见的恶性肿瘤，预后较差。 在日常实践以及临床，转化和基础研究中治疗这些患者时会遇到许多挑战。 目的：本综述总结了BTC临床和转化研究中最相关的挑战，并提出了改善生活质量和诊断为恶性肿瘤的患者预后的潜在解决方案。 调查结果：主要挑战是患有BTC的患者人数少，并伴随着癌症侵略性的自然行为以及缺乏研究资金来源的情况。 另外，这些患者的临床特征以及与癌症相关的特定并发症挑战了临床研究和临床试验招募。 值得强调的是，BTC是一组不同的恶性肿瘤（胆管癌，胆囊癌和壶腹癌），而不是独特的同类疾病。 这些亚组不仅在分子方面不同，而且在临床和人口统计学特征上也不同。 此外，需要定制的成像和生活质量评估来解决BTC特有的一些问题。 最后，就活检尺寸和样本中是否包含足够的肿瘤而言，组织获取方面的困难可能会对翻译和基础研究产生不利影响。 结论：越来越多的患者和临床医生对BTC的了解以及对进一步研究和治疗开发的需求可能解决了BTC研究中的一些主要挑战。 必须进行国际合作才能推动这一领域的发展。

关键词: 胆道癌，胆管癌，胆囊，壶腹，研究，挑战，临床，转化。

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