Neuronal Development-Related miRNAs as Biomarkers for Alzheimer's Disease, Depression, Schizophrenia and Ionizing Radiation Exposure

doi:10.2174/0929867327666200121122910
摘要

辐射暴露可能导致阿尔茨海默病(AD)、抑郁症或精神分裂症。大量实验和临床研究表明，miRNA参与了这些疾病的发展，也参与了脑辐射暴露后的神经病理学改变。目前的文献综述表明65个miRNA参与了大脑中的神经元发育。在脑组织、血液或脑脊液(CSF)中，分别有11、55或28个miRNAs参与AD的发展，在抑郁症中有89、50、19个miRNAs，在精神分裂症中有102、35、8个miRNAs。通过回顾现有的数据，我们比较了调控神经元发育的miRNA和参与AD、抑郁症和精神分裂症的发生的miRNA，以及驱动辐射诱导的脑神经病理学改变的mirna。我们发现3,11或8个日神经开发相关的微粒的脑组织,13，16或14个miRNA的血患者广告,抑郁和精神分裂症分别也参与辐射诱导大脑病变,暗示可能具体参与这些miRNA在辐射诱导广告的发展,分别抑郁症和精神分裂症。另一方面,我们指出,辐射诱导两个miRNA的变化也就是说,miR - 132, miR-29脑组织,三个微粒,例如,miR - 29 c-5p, miR - 106 b - 5 - p, miR-34a-5p血液中也参与广告的发展,抑郁和精神分裂症,从而表明这些微RNA可能参与共同的大脑神经病理变化,如神经发生损伤和降低学习记忆能力在这三种疾病和辐射暴露后。
关键词: miRNAs，脑组织，脑脊液，血液，阿尔茨海默病，抑郁症，精神分裂症和辐射，维恩图解。
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DOI https://dx.doi.org/10.2174/0929867327666200121122910	Print ISSN 0929-8673
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当代药物化学

神经元发育相关的miRNAs作为阿尔茨海默病、抑郁症、精神分裂症和电离辐射暴露的生物标记物

摘要

当代药物化学

神经元发育相关的miRNAs作为阿尔茨海默病、抑郁症、精神分裂症和电离辐射暴露的生物标记物

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