摘要
近几十年来,肥胖的患病率增加了两倍,肥胖已成为一个令人担忧的公共健康问题。近年来,一组内分泌干扰物,即肥胖源(obesogens),已经与肥胖症的流行直接相关。它的病因通常与久坐的生活方式、高脂肪饮食和遗传易感有关,但环境因素,如肥胖源,也被报道为导致这种病理的因素。简而言之,环境致肥源是改变新陈代谢过程和/或能量平衡和食欲的外源性化合物,因此容易导致体重增加。尽管这一理论仍然是最近才出现的,但怀疑具有致胖活性的化合物的数量多年来一直在稳步增加,尽管其中许多仍存在争议。技术级氯丹是一种广泛存在于环境中的有机氯农药,尽管浓度很低。高亲脂性化合物可以被人和动物代谢成毒性更强、更稳定的化合物,储存在脂肪组织中,从而对人体构成危险,包括脂肪组织的生理,在体重调节中起重要作用。此外,技术级氯丹被列为持久性有机污染物,这是一组流行病学研究与包括肥胖在内的代谢紊乱有关的化学品。在这里,我们讨论作为公共健康威胁的环境致肥源的新角色。我们特别讨论了氯丹持久性在环境中的相关性,以及它对人类和动物健康的影响如何为其作为一种可能具有致肥活性的内分泌干扰物的作用提供证据。
关键词: 肥胖,肥胖因子,内分泌干扰物,有机氯,持久性有机污染物,技术级氯丹
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