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CNS & Neurological Disorders - Drug Targets

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ISSN (Print): 1871-5273
ISSN (Online): 1996-3181

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Review Article

Neuronal Excitability in Epileptogenic Zones Regulated by the Wnt/ Β-Catenin Pathway

Author(s): Carmen Rubio, Elisa Taddei, Jorge Acosta, Verónica Custodio and Carlos Paz*

Volume 19, Issue 1, 2020

Page: [2 - 11] Pages: 10

DOI: 10.2174/1871527319666200120143133

Price: $65

Abstract

Epilepsy is a neurological disorder that involves abnormal and recurrent neuronal discharges, producing epileptic seizures. Recently, it has been proposed that the Wnt signaling pathway is essential for the central nervous system development and function because it modulates important processes such as hippocampal neurogenesis, synaptic clefting, and mitochondrial regulation. Wnt/β- catenin signaling regulates changes induced by epileptic seizures, including neuronal death. Several genetic studies associate Wnt/β-catenin signaling with neuronal excitability and epileptic activity. Mutations and chromosomal defects underlying syndromic or inherited epileptic seizures have been identified. However, genetic factors underlying the susceptibility of an individual to develop epileptic seizures have not been fully studied yet. In this review, we describe the genes involved in neuronal excitability in epileptogenic zones dependent on the Wnt/β-catenin pathway.

Keywords: Wnt/β-catenin, neuronal excitability, epileptogenesis, genetic signaling, hippocampal formation, neurotransmitter secretion.

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Graphical Abstract

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