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Review Article

1-脱氧野尻霉素及其衍生物的文献综述

卷 28, 期 3, 2021

发表于: 14 January, 2020

页: [628 - 643] 页: 16

弟呕挨: 10.2174/0929867327666200114112728

价格: $65

摘要

1-脱氧野尻霉素(1-DNJ)是一种天然的糖类似物，具有独特的生物活性。1-DNJ是一种有效的α-葡萄糖苷酶抑制剂，具有抗高血糖、抗肥胖、抗病毒和抗肿瘤的特性。米格列醇、美格鲁特、米加司他等1-DNJ衍生物已应用于临床治疗糖尿病、溶酶体储存障碍等疾病。本文就1-DNJ的提取、测定、药代动力学、生物活性及其衍生物的临床应用等方面进行综述。

关键词: 1-脱氧野尻霉素，代谢物，米格列醇，美格鲁特，亚氨基糖，葡萄糖苷酶抑制剂

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