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Protein & Peptide Letters

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Review Article

The Renin-Angiotensin System in Huntington’s Disease: Villain or Hero?

Author(s): Thatiane C.G. Machado, Cristina Guatimosim* and Lucas M. Kangussu*

Volume 27, Issue 6, 2020

Page: [456 - 462] Pages: 7

DOI: 10.2174/0929866527666200110154523

Price: $65

Abstract

Huntington’s Disease (HD) is an autosomal dominant, progressive neurodegenerative disorder characterized by severe symptoms, including motor impairment, cognitive decline, and psychiatric alterations. Several systems, molecules, and mediators have been associated with the pathophysiology of HD. Among these, there is the Renin-Angiotensin System (RAS), a peptide hormone system that has been associated with the pathology of neuropsychiatric and neurodegenerative disorders. Important alterations in this system have been demonstrated in HD. However, the role of RAS components in HD is still unclear and needs further investigation. Nonetheless, modulation of the RAS components may represent a potential therapeutic strategy for the treatment of HD.

Keywords: Renin angiotensin system, angiotensin peptides, Huntington’s disease, neurodegenerative disorder, pathophysiology, peptide hormone.

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